Medicine and Health Sciences Commons^™

Neural Correlates Of Fear Extinction: Investing The Impact Of Puberty And Sex In Children And Adolescents Through Neuroimaging, Sneha Bhargava, Clara Zundel, Samantha Ely, Carmen Carpenter, Reem Tamimi, Leah Gowatch, Mackenna Shampine, Emilie-Clare O'Mara, Jovan Jande, Shravya Chanamolu, Ahmad Almaat, Hilary Marusak

Medical Student Research Symposium

Fear-based disorders, including anxiety and posttraumatic stress disorder, are more prevalent in females than males. Steroid hormones (e.g., estradiol) are involved in fear extinction learning and later recall—a process implicated in the pathophysiology of fear-based disorders. Fear-based disorders commonly emerge during the transition from childhood to adolescence, a period marked by the onset of puberty and a natural increase of steroid hormones. Here, we examined the effects of puberty, sex, and their interaction on extinction recall and underlying neural circuitry in youth. Eighty-five youth (6-17 years, 46% female) completed a two-day Pavlovian fear extinction paradigm while undergoing functional magnetic resonance …

Exploring The Neural Correlates Of Mindfulness-Based Interventions In Youth, Jovan Jande, Clara Zundel, Samantha Ely, Sneha Bhargava, Carmen Carpenter, Reem Tamimi, Leah Gowatch, Mackenna Shampine, Emilie-Clare O'Mara, Shravya Chanamolu, Hilary Marusak

Medical Student Research Symposium

Mindfulness based interventions (MBI) reduce the severity of anxiety and depression among a variety of populations. While the psychological benefits of MBIs are increasingly recognized, less is known about the underlying neural correlates—particularly during childhood and adolescence, a time when many psychopathologies begin to emerge. Here, we provide the first systematic review on the neural correlates of MBI in youth. We reviewed the PubMed database for original articles examining the neural correlates of MBI in youth (0-18 years) leveraging neuroimaging. The search yielded 331 studies, of which 13 were included in the review. These studies comprised 451 participants and were …

M-Chat Implementation Strategies To Improve Autism Screening Rates In Pediatric Clinics In Metro Detroit, Karamoja Monchamp

Medical Student Research Symposium

The Modified Checklist for Autism in Toddlers (M-CHAT) is the most widely used autism screening tool. However, current practices for M-CHAT roll-outs and follow-ups are not wide-reaching, culturally sensitive, or consistent. This study aims to address the existing barriers to universal autism screenings and design a sustainable implementation strategy for a successful M-CHAT roll-out. We implemented strategies in five Henry Ford Health pediatric clinics, incorporating iPad-administered M-CHAT in waiting rooms, multilingual options, task shifting for referrals, forced choice mechanisms, and audit-and-feedback support. A Clinical Screening Dashboard tracked real-time M-CHAT data, including demographic information, collected from EPIC. Our goal is to …

Group-Based Four-Dimensional Brain Mapping Of Executive Control, Matthew T. Brennan, Kazuki Sakakura Md, Masaki Sonoda Md, Phd, Aimee Luat Md, Neena Marupudi, Sandeep Sood Md, Eishi Asano Md, Phd

Medical Student Research Symposium

Rationale: Humans utilize executive control processes to carry out non-automatic tasks. These tasks require coordination from higher brain centers to both suppress inappropriate behaviors and initiate correct responses. The goal of this study is to generate a novel, dynamic brain atlas to visualize and understand the network dynamics underlying executive control.

Methods: We studied 547 non-epileptic intracranial electrode sites sampled from seven patients with focal epilepsy. Each patient performed two types of verbal tasks: word-reading and Stroop color-naming. Mixed model analysis compared high-gamma cortical activation prior to response onset between the word-reading and Stroop color-naming tasks. Based on mixed model …

Childhood-Onset Attention-Deficit/Hyperactivity Disorder Exacerbates Opioid Use Disorder Consequences: Mediation By Impulsive Phenotypes, Liam R. Browning, Ciara Cannoy, Tabitha E. H. Moses, Leslie H. Lundahl Phd, David M. Ledgerwood Phd, Mark K. Greenwald Phd

Medical Student Research Symposium

Background: Attention deficit hyperactivity disorder (ADHD) is highly prevalent and associated with opioid use disorder (OUD). Yet, little is known about the mechanisms by which ADHD (which is a heterogeneous construct/diagnosis) might alter the trajectory of OUD outcomes.

Aim: This cross-sectional study examines relationships between childhood ADHD (inferred as predating substance use) and the extent to which the effects of ADHD on lifetime heroin-use consequences are mediated by foreshortened time perspective and drug-use impulsivity.

Methods: Individuals who report heroin use (N=214) were screened using the Assessment of Hyperactivity and Attention (AHA), Impulsive Relapse Questionnaire (IRQ), Stanford Time Perception Inventory (STPI), …

Glutamate, And Its Relationship To Task-Induced Functional Connectivity In The Human Brain: A Focus On Schizophrenia, Kathleen Liu Young, John Kopchick, Jeffrey Stanley, Vaibhav Diwadkar

Medical Student Research Symposium

Glutamate is the brain’s major excitatory neurotransmitter mediating both neuroplasticity and network function (Zhou & Danbolt, 2014). Basal glutamate (Glu) measured using proton magnetic resonance spectroscopy (1H-MRS) provides insight into a region’s density of neuropil related to the glutamatergic system. Moreover, given the role of glutamate in mediating brain network function, Glu levels may play a role in the brain’s functional connectivity (FC), which is typically estimated from functional magnetic resonance imaging (fMRI) time series data. These questions converge when considering the clinical syndrome of schizophrenia (SCZ). Patients with SCZ show abnormalities in basal Glu in the hippocampus and prefrontal …

The Impact Of Trauma Subtypes On Ptsd Severity In Syrian Child And Adolescent Refugees, Liza Hinchey, Lana Grasser, Bassem Saad, Kathleen Gorski, Arash Javanbakht, May Chammaa

Medical Student Research Symposium

Background:

Child and adolescent refugee populations are at increased risk for psychiatric disorders including posttraumatic stress disorder (PTSD) and anxiety. Recent studies have demonstrated different symptomatology based on the type(s) of traumatic events experienced. Cluster analyses based on the Life Events Checklist (LEC) indicate three trauma subtypes: accidental/injury, victimization, and predominant death threat. Extending this line of research from adults to youth may lead to better understanding of the unique impacts of trauma subtypes on symptoms for improved prediction of risk and resilience.

Methods:

Refugee participants were recruited within 1 month of their resettlement in the U.S. Data used were …

Norepinephrine Regulation Of Spatial Memory Using The Barnes Maze In Male And Female Rats, Serena Simpson, Ali Gheidi Phd, Nareen Sadik, Cameron J. Davidson Phd, Shane A. Perrine Phd

Medical Student Research Symposium

The role of norepinephrine (NE) in learning and memory has been extensively studied, yet its contribution remains to be clarified. This study aimed to investigate the role of NE on spatial learning and memory in female and male rats using a Barnes maze assay. We used N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), a specific noradrenergic neurotoxin that can cross the blood brain barrier, to deplete NE stores. We hypothesized that brain NE ablation would attenuate spatial learning and memory in rats. Loss of NE by DSP-4 was determined by measuring NE (and dopamine and serotonin) levels in several brain regions using HPLC. For the …

Learning Without Contingencies Induces Higher Order Asynchrony In Brain Networks In Schizophrenia, Elizabeth L. Martin, Asadur Chowdury, Vaibhav Diwadkar, Sazid Hasan, Munajj Ul-Huq, Shahira Baajour, Dalal Khatib, Usha Rajan, Jeffrey Stanley

Medical Student Research Symposium

Schizophrenia (SCZ) is characterized by both cognitive and reward impairments. A recent study suggests that SCZ is associated with a loss of synchrony between learning and reward circuits (Robison et al., 2019) and higher levels of dis-organization of functional brain networks may underpin failures in learning that characterize SCZ (Hütt et al., 2014). Therefore, here we examined inter-group (HC ≠ SCZ) 4^th order differences in statistical regularity across a connectome of cognition and reward brain circuits. The analyses were conducted on fMRI time series data from a previous learning paradigm (Stanley et al., 2017) with periods of Encoding and …

Role Of Oxidative Stress And Neuroinflammation Response In Pain Brain Regions After Traumatic Brain Injury, Alyssa Goodwin, Julia Malewicz, Scott Lloyd, Min Wu, Kelly Bosse, Alana Conti

Medical Student Research Symposium

Traumatic brain injury (TBI) affects approximately 3 million people annually, with 70-80% presenting with pain symptoms. Research has shown that increased reactive oxygen species (ROS) and neuroinflammation play a role in both pain and TBI, but the roles and interaction of oxidative stress and inflammation in TBI-related pain remain unclear. The purpose of the current study is to establish molecular data supporting proposed alterations in ROS and neuroinflammation in a mouse model of TBI in pain-related brain regions and to quantify how levels of these mediators change over time. Once the time course is determined, it will allow for optimal …

Resident Heart Rate Variability During Cataract Surgery, Ahmad Baiyasi, Shibandri Das, Ferris Bayasi, Faisal Ridha Al-Timimi

Medical Student Research Symposium

Purpose: To evaluate ophthalmology resident anxiousness and cardiovascular response by tracking resident heart rate (HR) when performing cataract surgery during their last year of residency.

Methods: A prospective analysis of 31 cataract cases, completed by three residents (two females and one male), at the Kresge Eye Institute in August and September 2020 was performed. Inclusion criteria for cases included all cataract cases performed by PGY-4 residents at the Kresge Eye Institute who downloaded the Heart Graph app supported by iOS. Residents with android mobile devices were excluded from the study. Informed consent was obtained from all residents who utilized the …

Comparing The Characteristics Of Homeless Adults In Poland And The United States, Paul A. Toro, Karen Hobden, Kathleen Wyszacki Durham, Marta Oko-Riebau, Anna Bokszczanin

Psychology Faculty Research Publications

This study compared the characteristics of probability samples of homeless adults in Poland (N = 200 from two cities) and the United States (N = 219 from one city), using measures with established reliability and validity in homeless populations. The same measures were used across nations and a systemic translation procedure assured comparability of measurement. The two samples were similar on some measures: In both nations, most homeless adults were male, many reported having dependent children and experiencing out-of-home placements when they themselves were children, and high levels of physical health problems were observed. Significant national differences were …

Change In Coping And Defense Mechanisms Across Adulthood: Longitudinal Findings In A European-American Sample, Manfred Diehl, Helena Chui, Elizabeth L. Hay, Mark A. Lumley, Daniel Grühn, Gisela Labouvie-Vief

Psychology Faculty Research Publications

This study examined longitudinal changes in coping and defense mechanisms in an age- and gender- stratified sample of 392 European-American adults. Nonlinear age-related changes were found for the coping mechanisms of sublimation and suppression and the defense mechanisms of intellectualization, doubt, displacement, and regression. The change trajectories for sublimation and suppression showed that their use increased from adolescence to late middle age and early old age, and remained mostly stable into late old age. The change trajectory for intellectualization showed that the use of this defense mechanism increased from adolescence to middle age, remained stable until late midlife, and started …

Effects Of Anger Awareness And Expression Training Versus Relaxation Training On Headaches: A Randomized Trial, Olga Slavin-Spenny, Mark A. Lumley, Elyse R. Thakur, Dana C. Nevedal, Alaa M Hijazi

Psychology Faculty Research Publications

Background and purpose: Stress contributes to headaches, and effective interventions for headaches routinely include relaxation training (RT) to directly reduce negative emotions and arousal. Yet, suppressing negative emotions, particularly anger, appears to augment pain, and experimental studies suggest that expressing anger may reduce pain. Therefore, we developed and tested anger awareness and expression training (AAET) on people with headaches.

Methods: Young adults with headaches (N = 147) were randomized to AAET, RT, or a wait-list control. We assessed affect during sessions, and process and outcome variables at baseline and 4 weeks after treatment.

Results: On process measures, …

Parenting And Attachment Among Low-Income African-American And Caucasian Preschoolers, Casey A. Dexter, Kristyn Wong, Ann M. Stacks, Marjorie Beeghly, Douglas Barnett

Psychology Faculty Research Publications

Despite a plethora of research on parenting and infant attachment, much less is known about the contributions of parenting to preschool attachment, particularly within different racial groups. This study seeks to build on the extant literature by evaluating whether similar associations between parenting and attachment can be observed in African American and Caucasian families, and whether race moderates them. Seventy-four primary caregivers and their preschool children (51% African American, 49% Caucasian, 46% male) from similar urban, low income backgrounds participated in two visits four weeks apart when children were between four and five years of age. Attachment was scored from …

Duel Or Diversion? Conscientiousness And Executive Function In The Prediction Of Health And Longevity, Tim Bogg, Brent W. Roberts

Psychology Faculty Research Publications

Response to Hall and Fong Letter to the Editor in Annals of Behavioral Medicine 45(3).

The Case For Conscientiousness: Evidence And Implications For A Personality Trait Marker Of Health And Longevity, Tim Bogg, Brent W. Roberts

Psychology Faculty Research Publications

Purpose Recent initiatives by major funding agencies have emphasized translational and personalized approaches (e.g., genetic testing) to health research and health management. While such directives are appropriate, and will likely produce tangible health benefits, we seek to highlight a confluence of several lines of research showing relations between the personality dimension of conscientiousness and a variety of health-related outcomes.

Methods Using a modified health process model, we review the compelling evidence linking conscientiousness to health and disease processes, including longevity, diseases, morbidity-related risk factors, health-related psycho-physiological mechanisms, health-related behaviors, and social environmental factors related to health.

Conclusion We argue the …

Vascular Depression: An Early Warning Sign Of Frailty, Daniel Paulson, Peter A. Lichtenberg

Psychology Faculty Research Publications

Objectives: Frailty is a common geriatric disorder associated with ADL impairment, hospitalization, and death. Phenomenological evidence suggests that late-life depression (Katz, 2004), particularly vascular depression, may be a risk factor for frailty. This study tests that hypothesis.

Methods: We identified a sample of stroke-free women over the age of 80 from the Health and Retirement Survey. The sample included 984 respondents in 2000 (incidence sample). Of these, 459 were non-frail at baseline and still alive in 2004 (prevalence sample). Frail respondents experienced at least three of the following: wasting, exhaustion, weakness, slowness, and falls. Vascular depression was represented using two …

Social Goals In Urban Physical Education: Relationships With Effort And Disruptive Behavior, Alex C. Garn, Nate Mccaughtry, Bo Shen, Jeffrey J. Martin, Mariane Fahlman

Kinesiology, Health and Sport Studies

This study investigated the relationships among four distinct types of social goals, effort, and disruptive behavior in urban physical education. Social responsibility, affiliation, recognition, status goals, along with effort and disruptive behavior in physical education were reported by high school physical education students (N = 314) from three urban schools. Findings from correlation and structural equa- tion modeling analyses revealed that social responsibility goals had a positive relationship with effort and an inverse relationship with disruptive behavior. Social status goals demonstrated a positive relationship with disruptive behavior and no relationship with effort. Social recognition goal results were mixed, as …

Motivational Profiles And Their Associations With Achievement Outcomes, Bo Shen, Nate Mccaughtry, Jeffrey J. Martin, Mariane Fahlman

Kinesiology, Health and Sport Studies

With the belief that theoretical integration in motivation may help us better understand motivational behavior, we designed this study to explore adolescents’ motivational profiles and their associations with knowledge acquisition, leisure-time exercise behaviors, and cardiorespiratory fitness. Middle school students from a large urban inner-city school district (N = 603, ages 12–14) completed questionnaires assessing motivational constructs and leisure-time exercise behavior. Knowledge and cardiorespiratory fitness were also assessed with a knowledge test and the Progressive Aerobic Cardiovascular Endurance Run (PACER) test, respectively. Using hierarchical cluster analysis, we found that students’ motivation in physical education could be explained from a multi-theoretical …

The Theory Of Planned Behavior: Predicting Physical Activity In Mexican American Children, Jeffrey J. Martin, Kimberly L. Oliver, Nate Mccaughtry

Kinesiology, Health and Sport Studies

Theoretically grounded research on the determinants of Mexican American children's physical activity and related psychosocial variables is scarce. Thus, the purpose of our investigation was to evaluate the ability of the theory of planned behavior (TPB) to predict Mexican American children's self-reported moderate-to-vigorous physical activity (MVPA). Children (N = 475, ages 9–12) completed questionnaires assessing the TPB constructs and MVPA. Multiple regression analyses provided moderate support for the ability of the TPB variables to predict MVPA as we accounted for between 8–9% of the variance in MVPA. Attitude, subjective norm, and perceived behavioral control accounted for 45% of the …

Determinants Of Physical Activity In An Inclusive Setting, Stephen Kodish, Pamela Hodges Kulinna, Jeffrey J. Martin, Robert Pangrazi, Paul Darst

Kinesiology, Health and Sport Studies

The purposes of this study included (a) to determine if the Theory of Planned Behavior (TPB) predicted intentions of individuals with and without disabilities to be physically active, (b) to determine if the TPB predicted behaviors of individuals with and without disabilities to be physically active, and (c) to determine if significant differences were present in physical activity opportunities between inclusive and non-inclusive elementary physical education classes taught by the same teacher. Students (N = 114, ages 10-13) completed questionnaires assessing the TPB constructs and had four days of PA evaluated through pedometer measurements. Analyses revealed that subjective norm …

Psychosocial Aspects Of Youth Disability Sport, Jeffrey J. Martin

Kinesiology, Health and Sport Studies

Psychosocial aspects of participation in youth disability sport were examined using social-cognitive theory and the sport commitment model. An international sample of athletes with disabilities (N = 112) reported high levels of sport commitment and sport enjoyment, perceived physical ability, and sport friendship quality. They perceived their parents to provide moderately strong levels of encouragement of their sport participation. Correlational analyses indicated moderate to strong relationships among sport commitment, sport enjoyment, and perceived physical ability. Sport commitment, parental encouragement, and sport friendship quality were only somewhat related. Regression analyses indicated that enjoyment was a significant predictor (i.e., 43% of …

The Theory Of Planned Behavior: Predicting Physical Activity And Cardiorespiratory Fitness In African American Children, Jeffrey J. Martin, Pamela Hodges Kulinna, Nate Mccaughtry, Donetta Cothran, Joe Dake, Gail Frances Fahoome

Kinesiology, Health and Sport Studies

The purpose of our study was to evaluate the ability of the Theory of Planned Behavior (TPB) to predict African American children’s moderate to vigorous physical activity (MVPA) and cardiorespiratory fitness. Children (N = 548, ages 9–12) completed questionnaires assessing the TPB constructs and MVPA and then had their cardiorespiratory fitness assessed with the Progressive Aerobic Cardiovascular Endurance Run (PACER) test. Commonly used Structural Equation Modeling fit indices suggested the model was an adequate representation for the relationships within the data. However, results also suggested an extended model which was examined and supported. Tests of direct paths from subjective …

A Social Cognitive Perspective Of Physical-Activity-Related Behavior In Physical Education, Jeffrey J. Martin, Pamela Hodges Kulinna

Kinesiology, Health and Sport Studies

The purpose of the current study was to examine student and teacher physical-activity-related behavior using the theory of planned behavior and self-efficacy theory. Although teachers reported an overwhelmingly positive attitude toward teaching physical activity lessons to promote fitness development, they only devoted 4% of their class time to actually demonstrating and promoting fitness. Students were quite sedentary during class spending 61% of class time sitting, standing, or lying down. Using hierarchical regression analyses, teachers' attitudes toward teaching physically active physical education classes accounted for 50% of the variance in teachers' intention. Teachers who demonstrated/promoted fitness and who limited their general …

Danger At The Edge Of Chaos: Predicting Violent Behavior In A Post-Daubert World, Erica Beecher-Monas, Edgar Garcia-Ril

Law Faculty Research Publications

No abstract provided.

Father Hunger: Explorations With Adults And Children (Book Review), Jerrold R. Brandell

Social Work Faculty Publications

Herzong, James M. (2001). Father Hunger: Explorations With Adults and Children. Hillsdale, NJ: The Analytic Press.

Respecting Pandora's Box, Erica Beecher-Monas

Law Faculty Research Publications

No abstract provided.

Sex And Temperament In Modern Society: A Darwinian View Of The “Glass Ceiling” And The “Gender Gap” In Compensation, Kingsley R. Browne

Law Faculty Research Publications

No abstract provided.

The Relationships Among Competitiveness, Age And Ability In Distance Runners, Robert C. Eklund, Jeffrey J. Martin, Alan L. Smith

Kinesiology, Health and Sport Studies

The purpose of this study was to examine relationships suggested by general achievement motivation literature and the popular literature in sport using the Sport Orientation Questionnaire (SOQ). The current study examined if faster runners are more competitive than slower runners, if older athletes were less competitive than younger athletes, and if faster runners were more goal oriented than slower runners. Distance runners (n=80), ranging from 10 to 61 years old completed race packets containing a cover letter, consent forms, the SOQ and a demographic questionnaire. Runners averaged 32.9 years of age and reported levels of competitiveness and goal …