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Full-Text Articles in Medicine and Health Sciences
Sleep Disturbances And Depression: The Role Of Genes And Trauma, Mackenzie J. Lind
Sleep Disturbances And Depression: The Role Of Genes And Trauma, Mackenzie J. Lind
Theses and Dissertations
Sleep disturbances and insomnia are prevalent, with around 33% of adults indicating that they experience at least one main symptom of insomnia, and bidirectional relationships exist with common psychopathology, particularly major depressive disorder (MDD). However, genetic and environmental (e.g., traumatic event exposure) contributions to the etiology of these phenotypes are not yet well understood. A genetically informative sample of approximately 12,000 Han Chinese women aged 30-60 (50% with recurrent MDD) was used to address several gaps within the sleep literature. Sleep disturbances were assessed in all individuals using a general item addressing sleeplessness (GS). A sleep within depression sum score …
Developmental Trajectories Of Alcohol Use And Alcohol Use Disorder, Elizabeth C. Long
Developmental Trajectories Of Alcohol Use And Alcohol Use Disorder, Elizabeth C. Long
Theses and Dissertations
Alcohol use (AU) and alcohol use disorder (AUD) are leading causes of morbidity, premature death, and economic burden. They are also associated with high levels of disability and many other negative outcomes. Twin and family studies have consistently shown that AU and AUD are complex traits influenced by both genetic and environmental factors. Although much has been learned about the genetic and environmental etiology of AU and AUD, significant gaps remain. These include the need for a more comprehensive understanding of the roles of risk and protective factors, and the nature of developmental trajectories underpinning the progression from AU to …