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Articles 1 - 30 of 150
Full-Text Articles in Medicine and Health Sciences
Utilizing Ai Integrated Neuroimaging Technology To Expand Upon Machine Learning In Positron Emission Tomography Technology With The Aim Of Detecting Amyloid Beta Biomarkers Early In The Onset Of Alzheimer's., Ethan S. Terman
Undergraduate Research Posters
Early intervention in Alzheimer's is vital for treatment. The earlier a professional can detect symptoms and make a diagnosis the earlier a prognosis can be implemented. With the prevalence of data in our day-to-day world combined with Artificial intelligence (AI), utilizing both for machine learning can pave the way for more accurate and efficient detection of Alzheimer's and other neurodegenerative diseases. AI combined with Machine learning (ML) increases diagnostic efficiency and reduces human errors, making it a valuable resource for physicians and clinicians alike. With the increasing amount of data processing and image interpretation required, the ability to use AI …
The Influence Of Flavor On The Abuse Liability Of A Heated Tobacco Product And Its Feasibility As A Menthol Cigarette Substitute, Augustus White
The Influence Of Flavor On The Abuse Liability Of A Heated Tobacco Product And Its Feasibility As A Menthol Cigarette Substitute, Augustus White
Theses and Dissertations
Heated Tobacco Products (HTPs) purport to expose people that use cigarettes to fewer of the harmful or potentially harmful constituents of tobacco while still delivering reinforcing amounts of nicotine (Auer, Concha-Lozano et al., 2017). An exemplar of the HTP class, IQOS, and its three varieties of “HeatSticks” have been authorized by the Food and Drug Administration (FDA) as “Modified Risk Tobacco Products” (MRTP). However, as the FDA is planning to ban menthol as a characterizing flavor in cigarettes, questions remain regarding whether characterizing flavors should be permitted in HTPs (FDA, 2022e). New evidence regarding HTP abuse liability (i.e., the likelihood …
Trauma In Weird Literature: Weird Experiences And Neuropsychiatric Conditions, Mijin Cho
Trauma In Weird Literature: Weird Experiences And Neuropsychiatric Conditions, Mijin Cho
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
This study aims to explore the element of trauma or shock in weird fiction using H. P. Lovecraft’s “The Colour out of Space” as the focal text. I am interested in the cognitive estrangement and body disfigurement following encounters with the weird, which in this case would be the meteorite’s Colour, on the characters experiencing it in the story, including the Gardners and Ammi. The goal is to investigate our reactions to being pushed past our thresholds as human beings using analysis of characters, diction, and rhetoric in weird fiction stories and non-fiction patient narratives to better understand how weird …
Improving Medication-Enhanced Psychotherapy Options For Ptsd: The Potential Of Oxytocin As A Treatment For Hypervigilance In Women With A History Of Childhood Sexual Abuse And Related Ptsd, Elianna Bavuso
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
Childhood sexual abuse (CSA) is a notable public health concern, affecting a significant proportion of girls in high-income countries. A considerable number of CSA survivors develop Post-Traumatic Stress Disorder (PTSD) by adolescence, which is often considered to be a lifelong disorder with severe emotional and social consequences. Women with CSA-related PTSD display hypervigilance, which is characterized by significantly increased fear network activity and poor top-down control over the amygdala. This meta-analysis examines the potential of intranasal oxytocin (OT) as a treatment for hypervigilance symptoms in women with CSA-related PTSD. The evidence reviewed suggests that intranasal oxytocin can help normalize the …
Pmh Connect, English (Greyscale For Printing), Sara W. Moyer, Patricia Kinser
Pmh Connect, English (Greyscale For Printing), Sara W. Moyer, Patricia Kinser
School of Nursing Publications
Mental health related symptoms and associated experiences in the perinatal period present challenges, particularly regarding identification and appropriate management. Perinatal Mental Health (PMH) screening occurs in clinical settings on a more regular basis than ever before thanks to validated screening measures used at perinatal visits; however, pregnant and parenting individuals report several concerns when completing these screeners and providers report barriers in addressing resultant findings. To address barriers and enhance the PMH screening experience, this team of clinicians and researchers propose a tool – the PMH Connect: a Perinatal Mental Health Screening Connection, Education, and Decision Aid – to be …
School Division Policies Related To Suicide Prevention And Response, David Naff, Fatemah A. Khawaji, Morgan Meadowes, Jill Flynn, Meg Sheriff, Lauren Powell, Lisa Gwyn, Tameka Burroughs, Jean Samuel
School Division Policies Related To Suicide Prevention And Response, David Naff, Fatemah A. Khawaji, Morgan Meadowes, Jill Flynn, Meg Sheriff, Lauren Powell, Lisa Gwyn, Tameka Burroughs, Jean Samuel
MERC Publications
Suicide is one of the leading causes of death among youth age 10-19, and is an increasing concern in the wake of COVID-19. K-12 schools are crucial spaces for offering mental health support to students, and can implement policies to help prevent suicidal thoughts and behaviors. This MERC research and policy brief focuses on education policy related to suicide prevention and response. It is structured to answer five questions: 1) What are recent trends in youth suicide? 2) What does research show about school division policies that are effective in suicide prevention and response? 3) What policies in Virginia and …
The Role Of The Nlrp3 Inflammasome In Alzheimer's Disease, Ethan S. Terman
The Role Of The Nlrp3 Inflammasome In Alzheimer's Disease, Ethan S. Terman
Undergraduate Research Posters
This study examines the consequences of Alzheimer’s in rat and mice test subjects. The goal is to identify the effects of certain NLRP3 inhibiting drugs and to see if there are any noticeable effects in regards to impeding the pathological development of Alzheimer’s disease. The results are visualized by implementing the immunohistochemical process to identify neurodegeneration in the brain and to assess the expression levels of amyloid beta as an indicator of Alzheimer’s pathology. Other tests are also conducted on these transgenic mice to gauge cognitive functioning levels during the onset of their disease, those being behavior tests, but not …
Evaluating The Acute Effect Of Vaping On Food Intake, Gabrielle Maldonado
Evaluating The Acute Effect Of Vaping On Food Intake, Gabrielle Maldonado
Theses and Dissertations
Background: Weight control is a common motive for continued cigarette smoking, and weight concerns pose a barrier to quitting. These effects are driven in part by nicotine’s ability to reduce overall appetite and ultimately body weight. Electronic nicotine delivery systems (ENDS) have been marketed and used for weight control, suggesting that the use of these products potentially may share similar effects as well as barriers to quitting as observed for cigarette smoking. However, little to no controlled clinical lab evidence exists supporting ENDS use for weight control. The present study tested the influence of an ENDS on acute eating behavior …
Analysis Of Referrals To Trauma Psychology And Subsequent Development And Proof-Of-Concept Study Of Provider Mental Health Training At A Level I Trauma Center, Samantha Mladen
Theses and Dissertations
Introduction: Millions of people are traumatically injured each year, with a significant portion going on to develop negative mental health sequelae. Many Level I trauma centers are integrating psychologists to provide acute assessment and intervention to patients at risk for poor outcomes. However, medical providers receive very limited training in how to best refer patients to mental health services and may benefit from such education.
Objective: To characterize current patterns of referral to trauma psychology at a Level I trauma center and to develop, refine, and test proof-of-concept for a new training for referring providers.
Method: One year of patient …
Covid-19 Impact On Latinx Families Within The Rva Breathes Program, Abigail Poulston, Robin S. Everhart, Ph.D, Sarah C M Morton
Covid-19 Impact On Latinx Families Within The Rva Breathes Program, Abigail Poulston, Robin S. Everhart, Ph.D, Sarah C M Morton
Undergraduate Research Posters
RVA Breathes is a community-based asthma intervention program that aims to reduce asthma disparities among 5 to 11-year-old children in Richmond, Virginia. Prior to the pandemic, Latinx children faced greater disparities in asthma treatment and morbidity than non-Latinx White children. During the pandemic, there is evidence to suggest that these disparities may have been further exacerbated. Specifically, research shows that COVID-19 health disparities among Latinx individuals arose due to social inequities, such as poverty, living conditions, lack of access to health care, language barriers, and employment. The current study provides an overview of responses from 20 Latinx caregivers to pandemic-related …
Family-Based Support As Social Determinants Of Health Protective Factor On Depression Of Parents Of Children With Autism Spectrum Disorder, Bisola E. Duyile
Family-Based Support As Social Determinants Of Health Protective Factor On Depression Of Parents Of Children With Autism Spectrum Disorder, Bisola E. Duyile
Theses and Dissertations
All parents experience challenges in their caregiving roles (Barańczuk & Pisula, 2020). However, parents raising a child/children with disabilities experience different social barriers (Oliver, 1996) that may also contribute to additional stressors in their caregiving role (Tomeny, 2016). Although these parents, on average, have reported greater symptoms of depression than parents of typically developing children, research shows that parents who reported receiving social support had lower symptoms of depression and stress (Das et al., 2017; Singh et al., 2017). Through the social determinants of health (SDOH) framework (ODPHP, 2022), the present study investigated informal/family-based support and its protective impact on …
Exploration Of Dimensional Structure Of Major Psychiatric Disorders Reveals Relationship With Substance Use And Personality, Noah Berley
Theses and Dissertations
Objective: Using a mixture of statistical techniques like structural equation modeling, confirmatory, and exploratory factor analyses, we aimed to determine the genetic factor structure among Externalizing, Internalizing, and Psychotic spectrum disorders through methods that evaluate GWAS-based correlations. Additionally, a subsequent factor analysis based on the most suitable psychiatric model was conducted to understand how non-clinical behavioral traits align with this factor structure.
Methods: Publicly available GWAS summary statistics for twelve major psychiatric disorders, six substance use measures and two personality domains were incorporated into structural equation models. Using the GenomicSEM software package, GWAS-based correlations were estimated between all twelve disorders …
Behavioral Coping Phenotypes And Associated Psychosocial Outcomes Of Pregnant And Postpartum Women During The Covid-19 Pandemic, Denise M. Werchan, Cassandra L. Hendrix, Jennifer C. Ablow, Ananda B. Amstadter Phd, Autumn C. Austin, Vanessa Babineau, G. Anne Bogat, Leigh-Anne Cioffredi, Elisabeth Conradt, Sheila E. Cromwell, Dani Dumitriu, William Fifer, Morgan R. Firestein, Wei Gao, Ian H. Gotlib, Alice M. Graham, Kimberly D. Gregory, Hanna C. Gustafsson, Kathryn L. Havens, Brittany R. Howell, Kathryn L. Humphreys, Lucy S. King, Patricia Kinser, Elizabeth E. Krans, Carly Lenniger, Alytia A. Levendosky, Joseph S. Lonstein, Rachel Marcus, Catherine Monk, Sara W. Moyer, Maria Muzik, Amy K. Nuttall, Alexandra S. Potter, Amy Salisbury, Lauren C. Shuffrey, Beth A. Smith, Lynne Smith, Elinor L. Sullivan, Judy Zhou, Moriah E. Thomason, Natalie H. Brito
Behavioral Coping Phenotypes And Associated Psychosocial Outcomes Of Pregnant And Postpartum Women During The Covid-19 Pandemic, Denise M. Werchan, Cassandra L. Hendrix, Jennifer C. Ablow, Ananda B. Amstadter Phd, Autumn C. Austin, Vanessa Babineau, G. Anne Bogat, Leigh-Anne Cioffredi, Elisabeth Conradt, Sheila E. Cromwell, Dani Dumitriu, William Fifer, Morgan R. Firestein, Wei Gao, Ian H. Gotlib, Alice M. Graham, Kimberly D. Gregory, Hanna C. Gustafsson, Kathryn L. Havens, Brittany R. Howell, Kathryn L. Humphreys, Lucy S. King, Patricia Kinser, Elizabeth E. Krans, Carly Lenniger, Alytia A. Levendosky, Joseph S. Lonstein, Rachel Marcus, Catherine Monk, Sara W. Moyer, Maria Muzik, Amy K. Nuttall, Alexandra S. Potter, Amy Salisbury, Lauren C. Shuffrey, Beth A. Smith, Lynne Smith, Elinor L. Sullivan, Judy Zhou, Moriah E. Thomason, Natalie H. Brito
Psychiatry Publications
The impact of COVID-19-related stress on perinatal women is of heightened public health concern given the established intergenerational impact of maternal stress-exposure on infants and fetuses. There is urgent need to characterize the coping styles associated with adverse psychosocial outcomes in perinatal women during the COVID-19 pandemic to help mitigate the potential for lasting sequelae on both mothers and infants. This study uses a data-driven approach to identify the patterns of behavioral coping strategies that associate with maternal psychosocial distress during the COVID-19 pandemic in a large multicenter sample of pregnant women (N = 2876) and postpartum women ( …
The Emotional Word-Emotional Face Stroop Task In The Abcd Study: Psychometric Validation And Associations With Measures Of Cognition And Psychopathology, Harry R. Smolker, Kai Wang, Monica Luciana, James M. Bjork, Raul Gonzalez, Deanna M. B, Erin C. Mcglade, Roselinde H. Kaiser, Naomi P. Friedman, John K. Hewitt, Marie T. Banich
The Emotional Word-Emotional Face Stroop Task In The Abcd Study: Psychometric Validation And Associations With Measures Of Cognition And Psychopathology, Harry R. Smolker, Kai Wang, Monica Luciana, James M. Bjork, Raul Gonzalez, Deanna M. B, Erin C. Mcglade, Roselinde H. Kaiser, Naomi P. Friedman, John K. Hewitt, Marie T. Banich
Psychiatry Publications
Characterizing the interactions among attention, cognitive control, and emotion during adolescence may provide important insights into why this critical developmental period coincides with a dramatic increase in risk for psychopathology. However, it has proven challenging to develop a single neurobehavioral task that simultaneously engages and differentially measures these diverse domains. In the current study, we describe properties of performance on the Emotional Word-Emotional Face Stroop (EWEFS) task in the Adolescent Brain Cognitive Development (ABCD) Study, a task that allows researchers to concurrently measure processing speed/attentional vigilance (i.e., performance on congruent trials), inhibitory control (i.e., Stroop interference effect), and emotional information …
Age-Related Changes And Longitudinal Stability Of Individual Differences In Abcd Neurocognition Measures, Andrey P. Anokhin, Monica Luciana, Marie Banich, Deanna M. Barch, James M. Bjork, Marybel R. Gonzalez, Raul Gonzalez, Frank Haist, Joanna Jacobus, Krista Lisdahl, Erin Mcglade, Bruce Mccandliss, Bonnie Nagel, Sara J. Nixon, Susan Tapert, James T. Kennedy, Wesley K. Thompson
Age-Related Changes And Longitudinal Stability Of Individual Differences In Abcd Neurocognition Measures, Andrey P. Anokhin, Monica Luciana, Marie Banich, Deanna M. Barch, James M. Bjork, Marybel R. Gonzalez, Raul Gonzalez, Frank Haist, Joanna Jacobus, Krista Lisdahl, Erin Mcglade, Bruce Mccandliss, Bonnie Nagel, Sara J. Nixon, Susan Tapert, James T. Kennedy, Wesley K. Thompson
Psychiatry Publications
Temporal stability of individual differences is an important prerequisite for accurate tracking of prospective relationships between neurocognition and real-world behavioral outcomes such as substance abuse and psychopathology. Here we report age-related changes and longitudinal test-retest stability (TRS) for the Neurocognition battery of the Adolescent Brain and Cognitive Development (ABCD) study, which included the NIH Toolbox (TB) Cognitive Domain and additional memory and visuospatial processing tests administered at baseline (ages 9–11) and two-year follow-up. As expected, performance improved significantly with age, but the effect size varied broadly, with Pattern Comparison and the Crystallized Cognition Composite showing the largest age-related gain (Cohen’s …
Effects Of The Selective Gsk3b Inhibitor, Tideglusib, On Ethanol Consumption, Anxiety-Like Behavior, Taste Preference, And Downstream Proteins, Sam Gottlieb, Douglas Bledsoe, Jessica L. Maltman, Alanna Morgan, Jennifer T. Wolstenholme, Michael F. Miles
Effects Of The Selective Gsk3b Inhibitor, Tideglusib, On Ethanol Consumption, Anxiety-Like Behavior, Taste Preference, And Downstream Proteins, Sam Gottlieb, Douglas Bledsoe, Jessica L. Maltman, Alanna Morgan, Jennifer T. Wolstenholme, Michael F. Miles
Graduate Research Posters
Background: We have shown modulations in glycogen synthase kinase 3 beta (GSK3B) abundance or activity regulate ethanol consumption, suggesting potential as a therapeutic target for alcohol use disorder (AUD). Here we report the GSK3B inhibitor tideglusib’s actions on ethanol consumption, basal behaviors, and modulation of GSK3B targets.
Methods: C57BL/6J males and females received i.g. 200mg/kg tideglusib, except drinking-in-the-dark (males;100mg/kg i.p.). Drinking-in-the-dark (DID): Mice given 20% ethanol 4-hours, 4-days/week x 3 weeks and then i.p. tideglusib or vehicle x 4 days in a Latin Square design with ethanol consumption measured daily. Light/Dark Box: Mice gavaged with tideglusib or vehicle …
A Technology-Based, Mixed Methods Approach To Examining The Psychosocial Determinants Of Maternal Health Disparities, Hannah M. Ming
A Technology-Based, Mixed Methods Approach To Examining The Psychosocial Determinants Of Maternal Health Disparities, Hannah M. Ming
Theses and Dissertations
Background: Exposure to racism and discrimination in the U.S. increases Black women’s risk for experiencing maternal health disparities. Additionally, racism and discrimination affect maternal psychosocial well-being, creating evidence for a biopsychosocial relationship between racism and maternal health outcomes. However, current research does not define the psychosocial Black maternal self well. Given the dynamic relationship between racism, psychosocial well-being, and Black maternal health outcomes, research must comprehensively examine the Black maternal self. The operationalization of a comprehensive construct for Black maternal psychosocial well-being can improve understanding of the relationship between racism, psychosocial well-being, and Black maternal health outcomes.
Purpose: …
The Relationship Between Social Media Use And Depression And Anxiety Symptoms During Covid-19, Tene'sha L. Crews, Christina Sheerin
The Relationship Between Social Media Use And Depression And Anxiety Symptoms During Covid-19, Tene'sha L. Crews, Christina Sheerin
Undergraduate Research Posters
The rise of the coronavirus (COVID-19) pandemic has caused a global surge in exposure to disaster and crisis-related media. Increases in poor mental health outcomes such as anxiety and depression, are associated with increased exposure to such media content (Abbas et al., 2021; Riehm et al., 2020; Zhao & Zhou, 2020). In recent years, social media has become one of the most widely used sources for news; approximately 48% of adult Americans receive their news from social media (Pew Research Center, 2021). During the COVID-19 pandemic, there has been an increase in social media use due to social distancing and …
Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe
Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe
Theses and Dissertations
Research suggests that youth are dealing with a myriad of worries during the COVID-19 pandemic (Ellis et al., 2020), which highlights the need for investigations focused on child anxiety. However, to date little research has examined children’s anxiety in the COVID-19 pandemic nor the potential protective effects of the caregiver-child relationship. Therefore, this research aimed to contribute to the literature by investigating the influence of COVID-19 related stressors in younger children and leveraging children’s report of their own attachment security within their relationship with their caregiver and mental health. The current study used a national, quantitative survey of young children …
Sleep Self-Efficacy, Loneliness, And Physical Activity: Assessing The Pathways Between Sleep Quality And Mental Health Using Structural Equation Modeling, Amber M. Fox
Theses and Dissertations
Although there is robust empirical support that poor sleep contributes to declines in mental health, explanations of this relationship remain unclear. The purpose of the present study was to examine the pattern of associations between sleep quality, sleep self-efficacy, loneliness, physical activity, and mental health among U.S. adults across the lifespan, and whether they differed by gender or age group. A structural equation model with invariance analysis was developed and examined data from 2,300 adults (Mage = 44.1, SD = 16.78) participating in the online study Investigating Sleep Longitudinally Across Normal Development (ISLAND). Sleep quality was measured by …
Examination Of Common And Rare Variant Genetic Architecture Of Psychiatric Disorders, Mohammad Ahangari
Examination Of Common And Rare Variant Genetic Architecture Of Psychiatric Disorders, Mohammad Ahangari
Theses and Dissertations
Psychiatric disorders are often heterogenous in their manifestation and genome-wide association studies have identified many common risk variants involved in their polygenic architectures with varying degrees of pleiotropy. In recent years, large-scale biobanks have also begun sequencing the genome of their participants to elucidate the role of rare risk variation in the genetic architecture of complex phenotypes, including psychiatric traits. This dissertation sought to better understand the role of both common and rare risk variation in the genetic architecture of psychiatric disorders with a particular focus on schizophrenia and alcohol problems. In the first three analyses, we focused on characterizing …
Disparities Between Native Americans And Whites In Trajectories Of Functional Independence And Life Satisfaction Over The 5 Years After Traumatic Brain Injury, Jack Watson
Theses and Dissertations
A traumatic brain injury (TBI) can have a host of negative consequences including impairments to motor and cognitive function and can result in a decrease in quality of life (i.e., life satisfaction). TBI is one of the leading causes of death and disability worldwide and disproportionately affects Native Americans, who have the highest rates of TBI among all races in the U.S. and elevated likelihood for fatality and severe complications. The current study used a subsample of the national TBI Model Systems Database of 80 demographically and injury severity matched Native American and White individuals (total n = 160) to …
Defiantly Childlike: Using Aesthetic Resistance To Heal, Sarah K. Reagan
Defiantly Childlike: Using Aesthetic Resistance To Heal, Sarah K. Reagan
Theses and Dissertations
This thesis examines an alternative processing mechanism surrounding the act of healing after traumatic experiences in life. Using a methodology of iterative patterning and tool-pathing, a collection of inflatable garments and wooden mannequins analyzes defense mechanisms learned in early childhood development. This work highlights an essential body of recent scholarship that takes cuteification seriously to restore a childlike approach to mastering fear. This paper will review the definitions of cuteness and childlike humor and then describe how visual culture has implemented these components to subvert established power.
A Novel Approach To Reducing Adiposity Among Young Men, Jean M. Reading
A Novel Approach To Reducing Adiposity Among Young Men, Jean M. Reading
Theses and Dissertations
Background
Lifestyle intervention is the first line treatment for obesity. Yet, young men are underrepresented in lifestyle interventions, which is posited to be the result of unmet needs and overall low concern for weight management. The aims of this dissertation are to:
Papers 1 and 2: Test the preliminary efficacy, feasibility, and acceptability of a self-guided lifestyle intervention for young men.
Paper 3: Explore the behavioral and physiological factors associated with changes in adiposity among young men and women enrolled in a more intensive lifestyle intervention.
Results
Papers 1 and 2: The self-guided intervention produced modest weight …
Opioid System's Involvement In Ketamine's Antidepressant-Like Effects, Fan Zhang
Opioid System's Involvement In Ketamine's Antidepressant-Like Effects, Fan Zhang
Theses and Dissertations
Depression is one of the most debilitating disorders in the world. The currently available medications typically have a 2-4 week delay in their therapeutic effects and are ineffective for about 40% of patients. In 2000, a subanesthetic dose (0.5 mg/kg i.e.) of the dissociative anesthetic ketamine was reported to have both rapid and robust antidepressant effects in in treatment-resistant depressed patients. However, the mechanisms responsible for ketamine’s antidepressant effects remain unclear. In 2018, a clinical study reported that pretreatment with the nonselective opioid antagonist naltrexone attenuated the rapid antidepressant effect of ketamine in depressed patients. The current study investigated the …
Investigating Cannabinoid Type-1 Receptor (Cb1r) Positive Allosteric Modulators (Pams) In Mouse Models Of Overt Cannabimimetic Activity, Subjective Drug Effects, And Neuropathic Pain, Jayden Elmer
Theses and Dissertations
Chronic pain affects between 20 and 30 percent of the adult population in western countries and represents a wide array of specific etiologies (Berge, 2011). Neuropathic pain secondary to traumatic nerve injury, chemotherapeutic toxicity, or diseases (e.g., diabetes mellitus) is often refractory to conventional analgesics, with patients receiving less than 50% pain relief compared to placebo (Finnerup et al. 2010). The endocannabinoid system has shown potential as a therapeutic target for neuropathic pain wherein CB1 agonism via administration of exogenous agonists or pharmacological blockade of endocannabinoid catabolic enzymes exhibits efficacy in reversing allodynia in the chronic constriction injury (CCI) model …
Strengthening Mental Health Diagnostic Detection In Integrated Primary Care, Julia Brechbiel
Strengthening Mental Health Diagnostic Detection In Integrated Primary Care, Julia Brechbiel
Theses and Dissertations
Primary care behavioral health (PCBH) is crucial for providing mental health treatment to underserved, minority, and uninsured populations. There is a lack of knowledge about accurate mental health diagnoses at PCBH. Underdetection of mental health symptoms has the potential to worsen racial and socioeconomic disparities. Using an expert review process, I developed an abbreviated diagnostic clinical interview (ADCI) for integrated primary care. Next, patients (N = 82) completed the interview after attending PCBH appointments. According to the interview, 63.4% of participants met criteria for a diagnosis, while 64.7% received a diagnosis from their provider. A large portion of patients …
Effects Of (R,S)-Ketamine And (2r,6r)-Hydroxynorketamine: A Preclinical Study, Remington Rice
Effects Of (R,S)-Ketamine And (2r,6r)-Hydroxynorketamine: A Preclinical Study, Remington Rice
Theses and Dissertations
In 2017, 7.1% of US adults were diagnosed with depression, and 50% of patients received medication to treat their depression. Depression can cause severe interruptions in an individual's cognitive functioning and behaviors like sleeping, eating, working, and socializing. Unfortunately, approximately 40% of patients do not respond to treatment with monoaminergic medications (e.g. Prozac) and therapeutic effects may be delayed 2-8 weeks. Due to these therapeutic shortcomings, faster acting and more efficacious treatments are needed. Recent preclinical findings indicate potential for glutamatergic drugs like (R,S)-ketamine and (2R,6R) hydroxynorketamine to produce more rapid and longer-acting therapeutic effects. The antidepressant effectiveness of (R,S)-ketamine …
Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt
Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt
Theses and Dissertations
Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …
College Students’ Perceptions Of Popular Diets And Orthorexia Nervosa, Madison W. Weinstock
College Students’ Perceptions Of Popular Diets And Orthorexia Nervosa, Madison W. Weinstock
Theses and Dissertations
Data suggest that individuals’ purported dietary patterns influence others’ perceptions of them. However, few studies have investigated how adherence to specific popular diets might influence these perceptions. This study investigated female undergraduates’ (n = 463) perceptions of vignette characters described as adhering to specific dietary practices perceptions of a vignette character in a sample of 463 female undergraduates. Characters described as adhering to a Clean Eating diet were viewed most positively, followed by individuals on the Ketogenic diet or nondieters. Characters following an Intermittent Fasting diet, and those with Orthorexia Nervosa were viewed most negatively. These findings support the …