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Agomelatine;; bupropion;; treatment-resistant depression;; antidepressant efficacy;; term outcomes;; dont succeed;; disorder;; augmentation;; strategies;; metaanalysis;; tolerability;; medications;; outpatients;; Behavioral Sciences;; Neurosciences & Neurology
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Full-Text Articles in Medicine and Health Sciences
Combination Of Agomelatine And Bupropion For Treatment-Resistant Depression: Results From A Chart Review Study Including A Matched Control Group, K. W. Suhs, C. U. Correll, C. K. Eberlein, R. Pul, H. Frieling, S. Bleich, K. G. Kahl
Combination Of Agomelatine And Bupropion For Treatment-Resistant Depression: Results From A Chart Review Study Including A Matched Control Group, K. W. Suhs, C. U. Correll, C. K. Eberlein, R. Pul, H. Frieling, S. Bleich, K. G. Kahl
Journal Articles
Introduction: Although a growing selection of antidepressants is available, a significant number of patients do not reach clinical remission, despite multiple trials. Data concerning the efficacy and safety of combination therapies with newer antidepressants are limited. Methods: Fifteen inpatients with treatment-resistant depression (TRD), defined as Beck Depression Inventory-2 (BDI-2) scores >14 despite treatment with adequate doses of 1 antidepressant classes for 6weeks, were treated with agomelatine plus bupropion for 6weeks, and compared to 15 patients on antidepressant monotherapy with TRD matched on age, sex, and TRD stage based on retrospective chart review. The primary outcome was change in BDI-2 scores. …