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Full-Text Articles in Medicine and Health Sciences
Site-Specific Effects On Respiratory Rhythm And Pattern Of Ibotenic Acid Injections In The Pontine Respiratory Group Of Goats, Joshua M. Bonis, Suzanne Neumueller, Katie L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert Forster
Site-Specific Effects On Respiratory Rhythm And Pattern Of Ibotenic Acid Injections In The Pontine Respiratory Group Of Goats, Joshua M. Bonis, Suzanne Neumueller, Katie L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert Forster
Physical Therapy Faculty Research and Publications
To probe further the contributions of the rostral pons to eupneic respiratory rhythm and pattern, we tested the hypothesis that ibotenic acid (IA) injections in the pontine respiratory group (PRG) would disrupt eupneic respiratory rhythm and pattern in a site- and state-specific manner. In 15 goats, cannulas were bilaterally implanted into the rostral pontine tegmental nuclei (RPTN; n = 3), the lateral (LPBN; n = 4) or medial parabrachial nuclei (MPBN; n = 4), or the Kölliker-Fuse nucleus (KFN; n = 4). After recovery from surgery, 1- and 10-μl injections (1 wk apart) of IA were made bilaterally through the …