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Physical Sciences and Mathematics

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2017

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Articles 1 - 30 of 71

Full-Text Articles in Medicine and Health Sciences

Building Academic/Practitioner Teams For Human Rights Projects: Examples, Lessons Learned, And Pitfalls To Avoid, Theresa Harris Nov 2017

Building Academic/Practitioner Teams For Human Rights Projects: Examples, Lessons Learned, And Pitfalls To Avoid, Theresa Harris

Biennial Conference: The Social Practice of Human Rights

Academics are increasingly interested in getting out of their classrooms and labs to contribute their knowledge, expertise, and resources to help communities develop evidence-based policies. In addition to post-election initiatives such as the March for Science and 314 Action, many academics are joining “without borders”-type programs and organizations that connect academics with opportunities to volunteer their time and talents for “social good.”

One of the longest-running of these is On-call Scientists, an initiative of the American Association for the Advancement of Science (AAAS) that connects human rights organizations with pro bono scientists across all fields — life, physical, behavioral, and …


Parallelization Of A Three-Dimensional Full Multigrid Algorithm To Simulate Tumor Growth, Dylan Goodin, Chin F. Ng, Hermann B. Frieboes Oct 2017

Parallelization Of A Three-Dimensional Full Multigrid Algorithm To Simulate Tumor Growth, Dylan Goodin, Chin F. Ng, Hermann B. Frieboes

Commonwealth Computational Summit

We present the performance gains of an openMP implementation of a fully adaptive nonlinear full multigrid (FMG) algorithm to simulate three-dimensional multispecies desmoplastic tumor growth on computer systems of varying processing capabilities. The FMG algorithm is applied to solve a recently published thermodynamic mixture model that uses a diffuse interface approach with fourth-order reaction-advection-diffusion PDEs (Cahn-Hilliard-type equations) that are coupled, nonlinear, and numerically stiff. The model includes multiple cell species and extracellular matrix (ECM), with adhesive and elastic energy contributions in chemical potential terms, as well as including blood and lymphatic vessels represented as continuous vasculatures. Advection-reaction-diffusion PDEs are employed …


How Low Can You Go? Feature Selection For Drug Discovery, Derek Jones, Sally R. Ellingson, W. A. De Jong Oct 2017

How Low Can You Go? Feature Selection For Drug Discovery, Derek Jones, Sally R. Ellingson, W. A. De Jong

Commonwealth Computational Summit

The cost of bringing a drug to market depends on how quickly a candidate drug can be “discovered” and evaluated to ensure safety and effectiveness. In this work we develop a method for predicting whether a given drug and protein compound will “bind.” Our aim is to select a set of features to predict drug-protein interactions.

This study focuses on kinases. Kinase inhibitors are the largest class of new cancer therapies. Selective inhibition is difficult due to high sequence similarity, leading to off-target interactions and side-effects. Pictured here human c-SRC.


Structure-Based Drug Discovery: Computational Virtual Screening, Robert C. Monsen, Lynn Deleeuw, Jon Maguire, William L. Dean, Robert D. Gray, Jonathan B. Chaires, John O. Trent Oct 2017

Structure-Based Drug Discovery: Computational Virtual Screening, Robert C. Monsen, Lynn Deleeuw, Jon Maguire, William L. Dean, Robert D. Gray, Jonathan B. Chaires, John O. Trent

Commonwealth Computational Summit

No abstract provided.


The Dynamics Of An Epidemiological Model For Human Papillomavirus With Partial Vaccination In A Heterogeneous Population, Stefano Chiaradonna Oct 2017

The Dynamics Of An Epidemiological Model For Human Papillomavirus With Partial Vaccination In A Heterogeneous Population, Stefano Chiaradonna

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Dftd Age Structure And Vaccination Modeling, Christopher D. Bruno Oct 2017

Dftd Age Structure And Vaccination Modeling, Christopher D. Bruno

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Drawbacks Of Utilizing The Logit Link In Propensity Score Weighting Adjustment, Evrim Oral Oct 2017

Drawbacks Of Utilizing The Logit Link In Propensity Score Weighting Adjustment, Evrim Oral

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


The Kinetics Of Type I Interferons During Influenza A Virus Infection, Margaret A. Myers Oct 2017

The Kinetics Of Type I Interferons During Influenza A Virus Infection, Margaret A. Myers

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Handguns And Hotspots: Spatio- Temporal Models For Gun Violence In Chicago,Il, Shelby Scott Oct 2017

Handguns And Hotspots: Spatio- Temporal Models For Gun Violence In Chicago,Il, Shelby Scott

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Neglected Tools In Tropical Diseases: Lessons From Modeling Leishmaniasis, West Nile Virus, And Ebola, Anuj Mubayi Oct 2017

Neglected Tools In Tropical Diseases: Lessons From Modeling Leishmaniasis, West Nile Virus, And Ebola, Anuj Mubayi

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


The Role Of Intermittent Preventive Treatment For Malaria In Saving Lives And Promoting Drug Resistance, Carrie Manore Oct 2017

The Role Of Intermittent Preventive Treatment For Malaria In Saving Lives And Promoting Drug Resistance, Carrie Manore

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


A Stochastic Epidemiological Model Of The Response Of American Chestnut Populations To Fungal Blight, Kelsey Lieberman, Rebecca Rouleau, Anita Davelos Baines, Martin Allen Oct 2017

A Stochastic Epidemiological Model Of The Response Of American Chestnut Populations To Fungal Blight, Kelsey Lieberman, Rebecca Rouleau, Anita Davelos Baines, Martin Allen

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Mathematical Medicine: Modeling Disease And Treatment, Lisette Depillis Oct 2017

Mathematical Medicine: Modeling Disease And Treatment, Lisette Depillis

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Exploring An Autoimmune Hair Loss Condition Through Mathematical Modeling And Sensitivity Analysis, Atanaska Dobreva, Ralf Paus, Nick Cogan May 2017

Exploring An Autoimmune Hair Loss Condition Through Mathematical Modeling And Sensitivity Analysis, Atanaska Dobreva, Ralf Paus, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Uncovering Functional Relationships In Leukemia, Reginald Mcgee May 2017

Uncovering Functional Relationships In Leukemia, Reginald Mcgee

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling Hiv Dynamics Following 3bnc117 Antibody Infusion, Samantha Erwin May 2017

Modeling Hiv Dynamics Following 3bnc117 Antibody Infusion, Samantha Erwin

Biology and Medicine Through Mathematics Conference

No abstract provided.


A Deterministic Model Of The Effect Of Electric Field On Chemotherapeutics Delivery Into A Tumor, Maryam Moarefian, Luke Achenie May 2017

A Deterministic Model Of The Effect Of Electric Field On Chemotherapeutics Delivery Into A Tumor, Maryam Moarefian, Luke Achenie

Biology and Medicine Through Mathematics Conference

No abstract provided.


Simulating The Evolution Of Skin Melanoma Using Heat Transfer, Ephraim Agyingi May 2017

Simulating The Evolution Of Skin Melanoma Using Heat Transfer, Ephraim Agyingi

Biology and Medicine Through Mathematics Conference

No abstract provided.


A Mathematical Model Of The Effects Of Resistance Training On Body Composition, Marcella Torres, Angela Reynolds, Eric Trexler, Abbie Smith-Ryan May 2017

A Mathematical Model Of The Effects Of Resistance Training On Body Composition, Marcella Torres, Angela Reynolds, Eric Trexler, Abbie Smith-Ryan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Interaction Of The Tear Film With The Ocular Surface, Richard J. Braun, Amy Janett, Nicholas Gewecke, Spencer Walker May 2017

Interaction Of The Tear Film With The Ocular Surface, Richard J. Braun, Amy Janett, Nicholas Gewecke, Spencer Walker

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling Original Antigenic Sin In Dengue Viral Infection, Ryan Nikin-Beers May 2017

Modeling Original Antigenic Sin In Dengue Viral Infection, Ryan Nikin-Beers

Biology and Medicine Through Mathematics Conference

No abstract provided.


Adaptive Therapy: Modeling Evolutionary Principles In Anticancer Therapy, Jeffrey B. West May 2017

Adaptive Therapy: Modeling Evolutionary Principles In Anticancer Therapy, Jeffrey B. West

Biology and Medicine Through Mathematics Conference

No abstract provided.


Incorporating Vessel Wall Remodeling Into 1d Cardiovascular Network Models Of Pulmonary Hypertension, Mansoor A. Haider, Nicholas A. Hill, Mette S. Olufsen May 2017

Incorporating Vessel Wall Remodeling Into 1d Cardiovascular Network Models Of Pulmonary Hypertension, Mansoor A. Haider, Nicholas A. Hill, Mette S. Olufsen

Biology and Medicine Through Mathematics Conference

No abstract provided.


Immuno-Kinetics Of Immunotherapy: Dosing With Dcs, Elizabeth Zollinger May 2017

Immuno-Kinetics Of Immunotherapy: Dosing With Dcs, Elizabeth Zollinger

Biology and Medicine Through Mathematics Conference

No abstract provided.


Numerical Investigations Of Phase Lag Phenomena Within Living Biological Tissues During Thermal Therapy Applications, Pappu Kumar, K. N. Rai May 2017

Numerical Investigations Of Phase Lag Phenomena Within Living Biological Tissues During Thermal Therapy Applications, Pappu Kumar, K. N. Rai

Biology and Medicine Through Mathematics Conference

No abstract provided.


Firing Rate Heterogeneity And Consequences For Coding In Feedforward Circuits, Cheng Ly, Gary Marsat May 2017

Firing Rate Heterogeneity And Consequences For Coding In Feedforward Circuits, Cheng Ly, Gary Marsat

Biology and Medicine Through Mathematics Conference

No abstract provided.


On The Analysis Of The Sir Epidemic Model For Small Networks: An Application In Hospital Settings, Martin Lopez-Garcia May 2017

On The Analysis Of The Sir Epidemic Model For Small Networks: An Application In Hospital Settings, Martin Lopez-Garcia

Biology and Medicine Through Mathematics Conference

No abstract provided.


Methods For Parameter Estimation Of A Stochastic Seir Model, Kaitlyn Martinez May 2017

Methods For Parameter Estimation Of A Stochastic Seir Model, Kaitlyn Martinez

Biology and Medicine Through Mathematics Conference

No abstract provided.


The Role Of The Autologous Immune Response In Chronic Myelogenous Leukemia, Doron Levy May 2017

The Role Of The Autologous Immune Response In Chronic Myelogenous Leukemia, Doron Levy

Biology and Medicine Through Mathematics Conference

No abstract provided.


A Computational Model Of Variable Chest Wall Compliance In Extremely Preterm Infants, Laura Ellwein, Henry Rozycki May 2017

A Computational Model Of Variable Chest Wall Compliance In Extremely Preterm Infants, Laura Ellwein, Henry Rozycki

Biology and Medicine Through Mathematics Conference

No abstract provided.