Medicine and Health Sciences Commons^™

The Use Of Chloramines To Eradicate Quagga Mussel Larvae, Trea Lacroix, Kumud Acharya

Undergraduate Research Opportunities Program (UROP)

Quagga Mussels, Dressenia bugensis, are a growing problem in the western United States, particularly in their ability to infest underwater infrastructures and clog water intake pipes and screens of power and treatment plants. Chlorine has been found to be the most effective chemical to get rid of veligers (planktonic larval form of quagga mussels) in the pipes. However, chlorine leaves a residue called trihalomethane, which is a carcinogen at higher concentrations. The purpose of this project is to test the effectiveness of an alternate chemical, chloramines (chlorine and ammonia), which leaves behind little to no residual trihalomethane. Upon experimentation with …

Cell Migration Dynamics After Alteration Of Cell-Cell Contacts In Fibrosarcoma And Glioblastoma Cell Lines, Hassan S. Rizvi, Ronald K. Gary

Undergraduate Research Opportunities Program (UROP)

Cell migration is a vital component of metastasis. In this study, our intent was to study cell migration by alteration of the Wnt/GSK-3 Pathway. Since BeSO4 is a known GSK-3 kinase inhibitor, we hypothesized that this agent would cause cell migration to decrease as a result of β-catenin stabilization. Two human cell lines, HT-1080 (fibrosarcoma) and A172 (glioblastoma), were used to observe migration levels in the presence and absence of BeSO4. Our results show that cell migration is diminished for cells that were pre-treated with BeSO4, in comparison to the untreated (control) cells.

Synthesis Of Novel Aromatic Quinols For Colon And Renal Cancers, Bradley J. Davey, Tae Soo Jo, Pradip K. Bhowmik

Undergraduate Research Opportunities Program (UROP)

Colon Cancer: The third most common cancer in USA. More than 1 million Americans currently living with colon cancer. 148,810 new cases expected in 2010. 50,000 deaths annually.

Renal Cancer: Approximately 58,000 people diagnosed in USA annually. Seventh most common cancer and tenth most common cause of cancer related death in men.

Aromatic quinols have demonstrated in vitro antitumor activity. Three heteroaromatic quinols show antitumor activity.

Y-Aminobutyric Acid Inhibits Synergistic Interleukin-6 Release And Increases Intracellular Cytokine Content In C6 Astrocytoma Cells In Vitro, Daniella Sandoval, Becky M. Hess, Bryan L. Spangelo

Undergraduate Research Opportunities Program (UROP)

Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by memory loss and is the most common cause of dementia. It is has been hypothesized that pro-inflammatory cytokines induce the inflammation that is believed to be the cause of the neuronal death that is associated with AD. γ-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the Central Nervous System possessing membrane hyperpolarization or depolarization activities. A decline in GABA may enhance cytokine release in Alzheimer’s disease resulting in neuroinflammation. Therefore, we investigated the GABA-mediated suppression of the synergistic release of interleukin-6 (IL-6) induced by interleukin 1- (IL-1) and …

Undergraduate Research Opportunities Program 2010, University Of Nevada, Las Vegas

Undergraduate Research Opportunities Program (UROP)

The Undergraduate Research Opportunities Program (UROP) cultivates and supports research partnerships and invites undergraduates to work as the junior colleagues of faculty. The program offers the opportunity to work on cutting edge research—whether you join established research projects or pursue your own ideas. As participants, undergraduates engage in each phase of standard research activity: developing research plans, writing proposals, conducting research, analyzing data. and presenting research results in oral and written form. The projects take place over the summer, and research can be done in any academic department or interdisciplinary laboratory. Projects can last for an entire semester, and many …

Undergraduate Research Opportunities Program, University Of Nevada Las Vegas, College Of Sciences

Undergraduate Research Opportunities Program (UROP)

No abstract provided.