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Should Biomarker Estimates Of Hiv Incidence Be Adjusted?, Ron Brookmeyer
Should Biomarker Estimates Of Hiv Incidence Be Adjusted?, Ron Brookmeyer
Ron Brookmeyer
Objective: To evaluate adjustment procedures that have been proposed to correct HIV incidence rates derived from cross-sectional surveys of biomarkers (BED). These procedures were motivated by some reports that the biomarker BED approach overestimates incidence when compared to cohort studies.
Design: Considered the Hargrove and McDougal adjustment procedures that adjust biomarker estimates of HIV incidence rates for misclassification with respect to the timing of infections.
Methods: Performed mathematical and statistical analysis of the adjustment formulas. Evaluated sources of error in cohort studies of incidence that could also explain discrepancies between cohort and biomarker estimates.
Results: The McDougal adjustment has no …