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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Activity Of Analogs Of Anticancer Drugs On The Serine Protease Enzymes Subtilisin And Chymotrypsin, Dhatri Ravipati
Activity Of Analogs Of Anticancer Drugs On The Serine Protease Enzymes Subtilisin And Chymotrypsin, Dhatri Ravipati
Masters Theses & Specialist Projects
The anticancer activity of several platinum compounds is due to the formation of complexes with DNA. We hypothesize that the size and shape of the platinum compounds would impact interaction with proteins, and these interactions may be partly responsible for the anticancer activity. Chymotrypsin and subtilisin are serine proteases that have a histidine residue in the active site. We are investigating the inhibition of the digestive enzymes chymotrypsin and subtilisin by analogs of the anticancer drug cisplatin and trying to discern trends in the inhibition as the active site residues vary. In our research, we found that the enzyme subtilisin …
Inhibition Of Cysteine Protease By Platinum (Ii) Diamine Complexes, Chaitanya Rapolu
Inhibition Of Cysteine Protease By Platinum (Ii) Diamine Complexes, Chaitanya Rapolu
Masters Theses & Specialist Projects
Chemotherapy is the first line of treatment used in cancer. Chemotherapy drugs such as cisplatin, carboplatin and oxaliplatin are used in treatment. Cisplatin enters the cell through copper transporter CTR1 by passive diffusion and bind to DNA and proteins. Cisplatin is found to inhibit several enzymes targeting cysteine, histidine and methionine residues, which are expected to be responsible for its anticancer activity. A better understanding of how the size and shape and leaving ligands of platinum complexes affect cysteine protease, papain enzyme are studied. This could give new ways to optimize anticancer activity. The activity of papain enzyme was measured …
The Proliferation Of Vascular Smooth Muscle Cells Depends On Thioredoxin 1 Protein In A Model Of Pulmonary Hypertension, Viktoria Nelin
The Proliferation Of Vascular Smooth Muscle Cells Depends On Thioredoxin 1 Protein In A Model Of Pulmonary Hypertension, Viktoria Nelin
Mahurin Honors College Capstone Experience/Thesis Projects
Pulmonary hypertension (PH) is a disease which manifests itself in the lungs of both adults and children. Vascular proliferation and remodeling are the hallmarks of PH and are found mainly in the pulmonary arterial smooth muscle cells (PASMC). The cause of PASMC proliferation and vascular remodeling in PH is poorly understood. Hypoxia, or low oxygen content, underlies many forms of PH. Hypoxia results in alterations in the redox balance of the PASMC. Therefore, the aim of this study was to examine the role of the thioredoxin system, an antioxidant system in the cell, in hypoxia-induced proliferation in PASMC. Protein was …
Assessment Of Prenatal Care And Perinatal Outcomes In Kasigau, Kenya, Allison Smith
Assessment Of Prenatal Care And Perinatal Outcomes In Kasigau, Kenya, Allison Smith
Mahurin Honors College Capstone Experience/Thesis Projects
The World Health Organization (WHO) implemented the Millennium Declaration in 2000 to establish global health goals to be achieved by 2015. Two of these Millennium Development Goals (MDG’s) are directly related to maternal, neonatal and child health. Healthcare during the prenatal period can help achieve the WHO MDG’s for maternal health and child mortality. Evidence has shown that women in Kenya have limited access to prenatal care. This study focused on the prenatal care and postnatal outcome trends of the women in Kasigau, Kenya. Participants were surveyed in three villages (Rukanga, Makwasinyi, and Bhuguta) to determine if prenatal care was …
Innovative Purification Protocol For Heparin Binding Proteins: Relevance In Biopharmaceutical And Biomedical Applications, Sumit Batra
Masters Theses & Specialist Projects
Heparin binding (HB) proteins mediates a wide range of important cellular processes, which makes this class of proteins biopharmaceutically important. Engineering HB proteins could bring many advantages, but it necessitates cost effective and efficient purification methodologies compared to the currently available methods. One of the most important classes of heparin binding protein is the fibroblast growth factors (FGFs) and its receptors (FGFRs). In this study, we report an efficient off-column purification of FGF-1 from soluble fractions and purification of the D2 domain of FGFR from insoluble inclusion bodies, using a weak amberlite cation (IRC) exchanger. This approach is an alternative …
Topscholar®, Creating Opportunities [Brochure], Connie Foster, Jennifer Wilson
Topscholar®, Creating Opportunities [Brochure], Connie Foster, Jennifer Wilson
TopSCHOLAR® Presentations and Reports
No abstract provided.
Environmental Assessment & Monitoring Regime For Atrazine In Drinking Water For Kentucky
Environmental Assessment & Monitoring Regime For Atrazine In Drinking Water For Kentucky
Student Research Conference Select Presentations
To describe occurrence in the environment & sampling regime of atrazine in public water supplies in Kentucky.
41st Annual Wku Student Research Conference, Student Research Council, Western Kentucky University
41st Annual Wku Student Research Conference, Student Research Council, Western Kentucky University
Student Research Conference Select Presentations
No abstract provided.
Topscholar® Creating Opportunities [2011 Brochure], Connie Foster, Jennifer Wilson
Topscholar® Creating Opportunities [2011 Brochure], Connie Foster, Jennifer Wilson
TopSCHOLAR® Presentations and Reports
No abstract provided.