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Physical Sciences and Mathematics
University of Texas Rio Grande Valley
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Full-Text Articles in Medicine and Health Sciences
Divergent Directionality Of Immune Cell-Specific Protein Expression Between Bipolar Lithium Responders And Non-Responders Revealed By Enhanced Flow Cytometry, Keming Gao, Nicholas M. Kaye, Marzieh Ayati, Mehmet Koyuturk, Joseph R. Calabrese, Eric Christian, Hillard M. Lazarus, David Kaplan
Divergent Directionality Of Immune Cell-Specific Protein Expression Between Bipolar Lithium Responders And Non-Responders Revealed By Enhanced Flow Cytometry, Keming Gao, Nicholas M. Kaye, Marzieh Ayati, Mehmet Koyuturk, Joseph R. Calabrese, Eric Christian, Hillard M. Lazarus, David Kaplan
Computer Science Faculty Publications and Presentations
Background and Objectives: There is no biomarker to predict lithium response. This study used CellPrint™ enhanced flow cytometry to study 28 proteins representing a spectrum of cellular pathways in monocytes and CD4+ lymphocytes before and after lithium treatment in patients with bipolar disorder (BD). Materials and Methods: Symptomatic patients with BD type I or II received lithium (serum level ≥ 0.6 mEq/L) for 16 weeks. Patients were assessed with standard rating scales and divided into two groups, responders (≥50% improvement from baseline) and non-responders. Twenty-eight intracellular proteins in CD4+ lymphocytes and monocytes were analyzed with CellPrint™, an enhanced flow …