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Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Symposium of Student Scholars
Fragment-based drug discovery (FBDD) is a powerful tool for developing anticancer and antimicrobial agents. Within this, magnetic resonance spectroscopy (NMR) provides a comprehensive qualitative and quantitative approach to screening and validating weak and robust binders with targeted proteins, making NMR among the most attractive strategies in FBDD. Inhibitor of vertebrate lysozyme (Ivyp1) of P. aeruginosa serves as an excellent target because of its active cellular location and implications in clinical prognosis for cystic fibrosis and immunocompromised patients. This study uses current NMR and biophysical techniques to develop a covalent, fragment-linked warhead inhibitor for Ivyp1 through synthetic methods, warhead linking, and …
2022 - The Third Annual Fall Symposium Of Student Scholars
2022 - The Third Annual Fall Symposium Of Student Scholars
Symposium of Student Scholars Program Books
The full program book from the Fall 2022 Symposium of Student Scholars, held on November 17, 2022. Includes abstracts from the presentations and posters.
2022- The Twenty-Sixth Annual Symposium Of Student Scholars
2022- The Twenty-Sixth Annual Symposium Of Student Scholars
Symposium of Student Scholars Program Books
The full program book from the Twenty-sixth Annual Symposium of Student Scholars, held on April 19, 2022. Includes abstracts from the presentations and posters.