Medicine and Health Sciences Commons^™

Clostridium Tertium Peritonitis And Concurrent Bacteremia In A Patient With A History Of Alcoholic Cirrhosis, S. Scott Sutton, Mark Jumper, Ansal Shah, Babatunde Edun

Faculty Publications

Spontaneous bacterial peritonitis (SBP) is a recognized cause of morbidity and mortality in cirrhotic patients. Enterobacteriaceae have been isolated from the majority of peritonitis cases and the gram negative aerobe Escherichia coli is the most commonly isolated organism. Anaerobic organisms are rarely isolated because of the high oxygen tension in ascetic fluid. We report a patient with a history of alcoholic cirrhosis who developed SBP and concurrent bacteremia with the anaerobe Clostridium tertium. The patient was successfully treated with intravenous antibiotics and was discharged home on oral ciprofloxacin. This case report is unique in that it is the fourth …

Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough

Kevin M Rice

Background

Intra-abdominal infection or peritonitis is a cause for great concern due to high mortality rates. The prognosis of severe intra-abdominal infection is significantly diminished in the presence of acute kidney injury (AKI) which is often characterized by renal tubular cell death that can lead to renal failure. The purpose of the current study is to examine the therapeutic efficacy of cerium oxide (CeO₂) nanoparticles for the treatment of peritonitis-induced AKI by polymicrobial insult.

Results

A one-time administration of CeO₂ nanoparticles (0.5 mg/kg) in the absence of antibiotics or other supportive care, attenuated peritonitis-induced tubular dilatation and …

Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough

Eric Blough

Background Intra-abdominal infection or peritonitis is a cause for great concern due to high mortality rates. The prognosis of severe intra-abdominal infection is significantly diminished in the presence of acute kidney injury (AKI) which is often characterized by renal tubular cell death that can lead to renal failure. The purpose of the current study is to examine the therapeutic efficacy of cerium oxide (CeO2) nanoparticles for the treatment of peritonitis-induced AKI by polymicrobial insult. Results A one-time administration of CeO2 nanoparticles (0.5 mg/kg) in the absence of antibiotics or other supportive care, attenuated peritonitis-induced tubular dilatation and the loss of …

Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough

Nandini Manne

Background Intra-abdominal infection or peritonitis is a cause for great concern due to high mortality rates. The prognosis of severe intra-abdominal infection is significantly diminished in the presence of acute kidney injury (AKI) which is often characterized by renal tubular cell death that can lead to renal failure. The purpose of the current study is to examine the therapeutic efficacy of cerium oxide (CeO2) nanoparticles for the treatment of peritonitis-induced AKI by polymicrobial insult. Results A one-time administration of CeO2 nanoparticles (0.5 mg/kg) in the absence of antibiotics or other supportive care, attenuated peritonitis-induced tubular dilatation and the loss of …