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Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough
Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough
Kevin M Rice
Background
Intra-abdominal infection or peritonitis is a cause for great concern due to high mortality rates. The prognosis of severe intra-abdominal infection is significantly diminished in the presence of acute kidney injury (AKI) which is often characterized by renal tubular cell death that can lead to renal failure. The purpose of the current study is to examine the therapeutic efficacy of cerium oxide (CeO2) nanoparticles for the treatment of peritonitis-induced AKI by polymicrobial insult.
Results
A one-time administration of CeO2 nanoparticles (0.5 mg/kg) in the absence of antibiotics or other supportive care, attenuated peritonitis-induced tubular dilatation and …
Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough
Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough
Eric Blough
Background Intra-abdominal infection or peritonitis is a cause for great concern due to high mortality rates. The prognosis of severe intra-abdominal infection is significantly diminished in the presence of acute kidney injury (AKI) which is often characterized by renal tubular cell death that can lead to renal failure. The purpose of the current study is to examine the therapeutic efficacy of cerium oxide (CeO2) nanoparticles for the treatment of peritonitis-induced AKI by polymicrobial insult. Results A one-time administration of CeO2 nanoparticles (0.5 mg/kg) in the absence of antibiotics or other supportive care, attenuated peritonitis-induced tubular dilatation and the loss of …
Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough
Cerium Oxide Nanoparticles Attenuate Acute Kidney Injury Induced By Intra-Abdominal Infection In Sprague-Dawley Rats, Nandini Manne, Ravikumar Arvapalli, Niraj Nepal, Tolou Shokuhfar, Kevin M. Rice, Shinichi Asano, Eric Blough
Nandini Manne
Background Intra-abdominal infection or peritonitis is a cause for great concern due to high mortality rates. The prognosis of severe intra-abdominal infection is significantly diminished in the presence of acute kidney injury (AKI) which is often characterized by renal tubular cell death that can lead to renal failure. The purpose of the current study is to examine the therapeutic efficacy of cerium oxide (CeO2) nanoparticles for the treatment of peritonitis-induced AKI by polymicrobial insult. Results A one-time administration of CeO2 nanoparticles (0.5 mg/kg) in the absence of antibiotics or other supportive care, attenuated peritonitis-induced tubular dilatation and the loss of …