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Full-Text Articles in Medicine and Health Sciences
A New Approach To Measuring Estrogen Exposure And Metabolism In Epidemiologic Studies, R. G. Ziegler, J. M. Faupel-Badger, L. Y. Sue, B. J. Fuhrman, R. T. Falk, J. Boyd-Morin, M. K. Henderson, R. N. Hoover, Timothy D. Veenstra, L. K. Keefer, X. Xu
A New Approach To Measuring Estrogen Exposure And Metabolism In Epidemiologic Studies, R. G. Ziegler, J. M. Faupel-Badger, L. Y. Sue, B. J. Fuhrman, R. T. Falk, J. Boyd-Morin, M. K. Henderson, R. N. Hoover, Timothy D. Veenstra, L. K. Keefer, X. Xu
Pharmaceutical Sciences Faculty Publications
Endogenous estrogen plays an integral role in the etiology of breast and endometrial cancer, and conceivably ovarian cancer. However, the underlying mechanisms and the importance of patterns of estrogen metabolism and specific estrogen metabolites have not been adequately explored. Long-standing hypotheses, derived from laboratory experiments, have not been tested in epidemiologic research because of the lack of robust, rapid, accurate measurement techniques appropriate for large-scale studies. We have developed a stable isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS(2)) method that can measure concurrently all 15 estrogens and estrogen metabolites (EM) in urine and serum with high sensitivity (level of detection=2.5-3.0fmol …
Development And Validation Of A Rapid Method For The Detection Of Latrunculol A In Plasma., Jiajiu Shaw, Frederick A. Valeriote, Joseph Media, Tyler A. Johnson, Taro Amagata, Karen Tenney, Phillip Crews
Development And Validation Of A Rapid Method For The Detection Of Latrunculol A In Plasma., Jiajiu Shaw, Frederick A. Valeriote, Joseph Media, Tyler A. Johnson, Taro Amagata, Karen Tenney, Phillip Crews
Natural Sciences and Mathematics | Faculty Scholarship
Latrunculol A is a recently discovered 6,7-dihydroxy analog of the potent actin inhibitor latrunculin A. Latrunculol A has exhibited greater cytotoxicity than latrunculin A against both murine and human colon tumor cell lines in vitro. Currently, there are no reports regarding the bioavailability of latrunculol A in vivo. This study was undertaken as a prelude to pharmacokinetic assessments and it is the first work where bioavailability of latrunculol A was studied. In the present work, a simple plasma preparation and a rapid HPLC method have been developed. Mouse plasma containing latrunculol A was first treated by acetonitrile and then centrifuged …