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Application Of Cross-Linked Rice Starches As Drug Delivery Matrices In Monolithic Tablets, Christopher F. Peluso, Fernanda O. Onofre, Ya-Jane Wang

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

The sustained release properties of regular and waxy rice starches and their derivatives were studied in tablets. The starches were cross-linked to different levels with epichlorohydrin, and the sustained release properties, swelling power, and rheological characteristics of the matrices prepared were determined. Propranolol hydrochloride was used as a model drug. The sustained release properties of waxy rice starch improved with increasing cross-linking levels, whereas cross-linking had little impact on the functionality of regular rice starch matrices. There was an increase in swelling power for both regular and waxy rice starches as cross-linking levels increased. Both starches showed an increase in …