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Comparison Of Estrogens And Estrogen Metabolites In Human Breast Tissue And Urine, Emanuela Taioli, Annie Im, Xia Xu, Timothy D. Veenstra, Gretchen Ahrendt, Seymour Garte
Comparison Of Estrogens And Estrogen Metabolites In Human Breast Tissue And Urine, Emanuela Taioli, Annie Im, Xia Xu, Timothy D. Veenstra, Gretchen Ahrendt, Seymour Garte
Pharmaceutical Sciences Faculty Publications
BACKGROUND: An important aspect of the link between estrogen and breast cancer is whether urinary estrogen levels are representative of the intra-tissue levels of bioavailable estrogens.
METHODS: This study compares 15 estrogen and estrogen metabolite levels in breast tissue and urine of 9 women with primary breast cancer using a quantitative liquid chromatography-mass spectrometry method.
RESULTS: The average levels of estrogens (estrone, 17 beta-estradiol) were significantly higher in breast tissue than in urine. Both the 2 and the 16-hydroxylation pathways were less represented in breast tissue than urine; no components of the 4-hydroxypathway were detected in breast tissue, while 4-hydroxyestrone …