Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aluminum (1)
- Animals (1)
- Antineoplastic Agents (1)
- Biological Availability (1)
- Drug Administration Routes (1)
-
- Environmental Exposure (1)
- Fast Atom Bombardment (1)
- Female (1)
- Fertility (1)
- Food Supply (1)
- Gonadotropin-Releasing Hormone (1)
- Humans (1)
- Infertility (1)
- Infertility, Male (1)
- Litter Size (1)
- Male (1)
- Mass (1)
- Microspheres (1)
- Orchiectomy (1)
- Prostatic Neoplasms (1)
- Radioisotopes (1)
- Rats (1)
- Rats, Sprague-Dawley (1)
- Reproduction (1)
- Spectrometry (1)
- Spectrometry, Mass, Fast Atom Bombardment (1)
- Sprague-Dawley (1)
- Testosterone (1)
- Water Supply (1)
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Return To Fertility After Extended Chemical Castration With A Gnrh Antagonist, Janusz W. Kostanski, Ge Jiang, Bhas A. Dani, Santos B. Murty, Wei Qiu, Bruce Schrier, B. C. Thanoo, Patrick P. Deluca
Return To Fertility After Extended Chemical Castration With A Gnrh Antagonist, Janusz W. Kostanski, Ge Jiang, Bhas A. Dani, Santos B. Murty, Wei Qiu, Bruce Schrier, B. C. Thanoo, Patrick P. Deluca
Pharmaceutical Sciences Faculty Publications
BACKGROUND: Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats.
METHODS: Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). Serum orntide and testosterone levels in both groups were monitored at certain intervals for 9 months from the initiation of treatment. After …
Aluminium Toxicokinetics: An Updated Minireview, Robert A. Yokel, Patrick J. Mcnamara
Aluminium Toxicokinetics: An Updated Minireview, Robert A. Yokel, Patrick J. Mcnamara
Pharmaceutical Sciences Faculty Publications
This MiniReview updates and expands the MiniReview of aluminium toxicokinetics by Wilhelm et al. published by this journal in 1990. The use of 26Al, analyzed by accelerator mass spectrometry, now enables determination of Al toxicokinetics under physiological conditions. There is concern about aluminium in drinking water. The common sources of aluminium for man are reviewed. Oral Al bioavailability from water appears to be about 0.3%. Food is the primary common source. Al bioavailability from food has not been adequately determined. Industrial and medicinal exposure, and perhaps antiperspirant use, can significantly increase absorbed aluminium. Inhalation bioavailability of airborne soluble Al …