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Exploring The Structure-Activity Relationship Of Various Seh Inhibitors In Promoting Brown Adipogenesis, Sue Lim Choi
Exploring The Structure-Activity Relationship Of Various Seh Inhibitors In Promoting Brown Adipogenesis, Sue Lim Choi
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Background: Brown adipose tissue has emerged as a novel target for obesity prevention and treatment due to its responsibility for heat production. Soluble epoxide hydrolase (sEH) is a cytosolic enzyme that degrades epoxy fatty acids (EpFAs) (lipid signaling molecules) into inactive diols. Potent sEH inhibitors (sEHIs) are beneficial for many chronic diseases as they stabilize endogenous EpFAs by blocking the degradation. Our preliminary results have shown that trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB), a potent sEH inhibitor, dose-dependently promotes brown adipogenesis.
Objectives: The objective of this study is to investigate the structure and activity relationship of various sEHIs with different sub-structures of …