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Full-Text Articles in Medicine and Health Sciences
Development Of Cholesterol Modified Rnai Polyplexes For Breast Cancer Therapy, Zhen Ye
Development Of Cholesterol Modified Rnai Polyplexes For Breast Cancer Therapy, Zhen Ye
Theses & Dissertations
Not available.
Ocular, Neural, And Cellular Biodistribution Of Multifunctional Antioxidants, Damian Daszynski
Ocular, Neural, And Cellular Biodistribution Of Multifunctional Antioxidants, Damian Daszynski
Theses & Dissertations
Aging is a complex biological process which stems from a growing imbalance between the regenerative capacity of an organism and endogenous as well as exogenous damaging factors. This imbalance leads to the slow deterioration of individual cells, organs, and eventually the entire organism. The free radical theory of aging combines the evolutionary and mechanistic aspects of aging, postulating that the innate process is caused by deleterious, irreversible, and inevitable changes in biological systems caused by oxidative damage that accumulates over the lifespan. Evidence of this phenomenon is supported by the pathogenesis of age-related diseases, such as age-related macular degeneration and …
The Development Of Hyaluronan-Based Contract Agents For The Intraoperative Detection Of Pancreatic Tumors, Bowen Qi
Theses & Dissertations
Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. Tumor-specific intraoperative fluorescence imaging could improve staging and surgical resection, thereby improving prognosis. In the first study, hyaluronic acid derived NPs with physico-chemically entrapped indocyanine green, termed NanoICG, were utilized for intraoperative near infrared fluorescence detection of pancreatic cancer. NanoICG accumulated significantly in an orthotopic pancreatic ductal adenocarcinoma model with safety profile both in vitro and in vivo. To maximize tumor signal, while minimizing signal in healthy pancreas and RES capture of macromolecules, in the next study, we describe the rational …