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Full-Text Articles in Medicine and Health Sciences
Identification Of Membrane-Bound Variant Of Metalloendopeptidase Neurolysin (Ec 3.4.24.16) As The Non-Angiotensin Type 1 (Non-At1), Non-At2 Angiotensin Binding Site, Naomi J. Wangler, Kira L. Santos, Ines Schadock, Fred K. Hagen, Emanuel Escher, Michael Bader, Robert C. Speth, Vardan T. Karamyan
Identification Of Membrane-Bound Variant Of Metalloendopeptidase Neurolysin (Ec 3.4.24.16) As The Non-Angiotensin Type 1 (Non-At1), Non-At2 Angiotensin Binding Site, Naomi J. Wangler, Kira L. Santos, Ines Schadock, Fred K. Hagen, Emanuel Escher, Michael Bader, Robert C. Speth, Vardan T. Karamyan
HPD Articles
Recently, we discovered a novel non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site in rodent and human brain membranes, which is distinctly different from angiotensin receptors and key proteases processing angiotensins. It is hypothesized to be a new member of the renin-angiotensin system. This study was designed to isolate and identify this novel angiotensin binding site. An angiotensin analog, photoaffinity probe 125I-SBpa-Ang II, was used to specifically label the non-AT1, non-AT2 angiotensin binding site in mouse forebrain membranes, followed by a two-step purification procedure based on the molecular size and isoelectric point of the photoradiolabeled binding protein. Purified samples were …
College Of Pharmacy 2012, Nova Southeastern University
College Of Pharmacy 2012, Nova Southeastern University
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