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- Addiction; geographic analysis; opiate; opioid (1)
- Bacteroides thetaiotaomicron (1)
- Biogeography (1)
- Bisphosphonates; bone density; glucocorticoid; vertebral fracture (1)
- Broccoli sprouts (1)
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- COVID-19; epidemiology; health services accessibility; rehabilitation medicine; substance misuse (1)
- Cannabidiol (1)
- Crohn’s disease; cruciferous vegetables; sulforaphane; glucoraphanin; gut microbiota; dietary bioactives; 16S rDNA; interleukin-10 knockout (1)
- Dietary bioactives (1)
- Dronabinol (1)
- Food processing (1)
- Glucoraphanin (1)
- Gut microbiota (1)
- Inflammatory bowel disease (1)
- Invasive species (1)
- Medical marijuana (1)
- Muscular dystrophy; DMD; natural history; South Asia; genotype–phenotype (1)
- Prescription (1)
- Silver carp (1)
- Statistical methods; statistics (1)
- Sulfora phane (1)
- Thiaminase (1)
- Thiamine deficiency (1)
- Ulcerative colitis (1)
Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Dynamic Changes In Methadone Utilisation For Opioid Use Disorder Treatment: A Retrospective Observational Study During The Covid-19 Pandemic, Amy L. Kennalley, Jessica L. Fanelli, John A. Furst, Nicholas J. Mynarski, Margaret A. Jarvis, Stephanie D. Nicholas, Kenneth L. Mccall, Brian J. Piper
Dynamic Changes In Methadone Utilisation For Opioid Use Disorder Treatment: A Retrospective Observational Study During The Covid-19 Pandemic, Amy L. Kennalley, Jessica L. Fanelli, John A. Furst, Nicholas J. Mynarski, Margaret A. Jarvis, Stephanie D. Nicholas, Kenneth L. Mccall, Brian J. Piper
Pharmacy Faculty Scholarship
Objectives: Opioid use disorder (OUD) is a major public health concern in the USA, resulting in high rates of overdose and other negative outcomes. Methadone, an OUD treatment, has been shown to be effective in reducing the risk of overdose and improving overall health and quality of life. This study analysed the distribution of methadone for the treatment of OUD across the USA over the past decade and through the COVID-19 pandemic. Design: Retrospective observational study using secondary data analysis of the Drug Enforcement Administration and Medicaid Databases. Setting: USA. Participants: Patients who were dispensed methadone at US opioid treatment …
Moving Beyond The 2018 Minimum International Care Considerations For Osteoporosis Management In Duchenne Muscular Dystrophy (Dmd): Meeting Report From The 3rd International Muscle-Bone Interactions Meeting 7th And 14th November 2022, Kim Phung, Nicola Crabtree, Anne M. Connolly, Pat Furlong, Eric P. Hoffman, Stefan A. Jackowski, Soher Nagi Jayash, Alex Johnson, Khaldoun Koujok, Craig F. Munns, Erik Niks, Frank Rauch, Rachel Schrader, Cathy Turner, Elizabeth Vroom, David R. Weber, Brenda L. Wong, Michela Guglieri, Leanne M. Ward, Sze Choong Wong
Moving Beyond The 2018 Minimum International Care Considerations For Osteoporosis Management In Duchenne Muscular Dystrophy (Dmd): Meeting Report From The 3rd International Muscle-Bone Interactions Meeting 7th And 14th November 2022, Kim Phung, Nicola Crabtree, Anne M. Connolly, Pat Furlong, Eric P. Hoffman, Stefan A. Jackowski, Soher Nagi Jayash, Alex Johnson, Khaldoun Koujok, Craig F. Munns, Erik Niks, Frank Rauch, Rachel Schrader, Cathy Turner, Elizabeth Vroom, David R. Weber, Brenda L. Wong, Michela Guglieri, Leanne M. Ward, Sze Choong Wong
Pharmacy Faculty Scholarship
This current manuscript summarizes the proceedings of the “Third Muscle-bone interactions in Duchenne Muscular Dystrophy Symposium: Moving Beyond the 2018 Minimum International Standards of Care for Osteoporosis Management”, an event co-organized by the World Duchenne Organization (www.worldduchenne.org) and the International Conference on Children’s Bone Health (www.theiscbh.org). This virtual symposium, held on November 7th and 14th 2022, brought together a total of 385 delegates representing 55 countries registered for the symposium, which included 239 clinicians, 70 researchers, 40 patient representatives and others from pharmaceutical companies and regulators. This symposium aimed to review the evidence base that informed the 2018 international minimum …
Early Life Exposure To Broccoli Sprouts Confers Stronger Protection Against Enterocolitis Development In An Immunological Mouse Model Of Inflammatory Bowel Disease, Lola Holcomb, Johanna M. Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M. Mawe, Peter L. Moses, Emma Perry, Allesandra Stratigakis, Tao Zhang, Grace Chen, Suzanne L. Ishaq, Yanyan Li
Early Life Exposure To Broccoli Sprouts Confers Stronger Protection Against Enterocolitis Development In An Immunological Mouse Model Of Inflammatory Bowel Disease, Lola Holcomb, Johanna M. Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M. Mawe, Peter L. Moses, Emma Perry, Allesandra Stratigakis, Tao Zhang, Grace Chen, Suzanne L. Ishaq, Yanyan Li
Pharmacy Faculty Scholarship
Crohn’s disease (CD) is a presentation of inflammatory bowel disease (IBD) that manifests in childhood and adolescence and involves chronic and severe enterocolitis, immune and gut microbial dysregulation, and other complications. Diet and gut-microbiota-produced metabolites are sources of anti-inflammatories that could ameliorate symptoms. However, questions remain on how IBD influences biogeographic patterns of microbial location and function in the gut, how early life transitional gut communities are affected by IBD and diet interventions, and how disruption to biogeography alters disease mediation by diet components or microbial metabolites. Many studies on diet and IBD use a chemically induced ulcerative colitis model, …
Steamed Broccoli Sprouts Alleviate Dss-Induced Inflammation And Retain Gut Microbial Biogeography In Mice, Johanna M. Holman, Louisa Colucci, Dorien Baudewyns, Joe Balkan, Timothy Hunt, Benjamin Hunt, Marissa Kinney, Lola Holcomb, Allesandra Stratigakis, Grace Chen, Peter L. Moses, Gary M. Mawe, Tao Zhang, Yanyan Li, Suzanne L. Ishaq
Steamed Broccoli Sprouts Alleviate Dss-Induced Inflammation And Retain Gut Microbial Biogeography In Mice, Johanna M. Holman, Louisa Colucci, Dorien Baudewyns, Joe Balkan, Timothy Hunt, Benjamin Hunt, Marissa Kinney, Lola Holcomb, Allesandra Stratigakis, Grace Chen, Peter L. Moses, Gary M. Mawe, Tao Zhang, Yanyan Li, Suzanne L. Ishaq
Pharmacy Faculty Scholarship
Inflammatory bowel diseases (IBDs) are devastating conditions of the gastrointestinal tract with limited treatments, and dietary intervention may be effective and affordable for managing symptoms. Glucosinolate compounds are highly concentrated in broccoli sprouts, especially glucoraphanin (GLR), and can be metabolized by certain mammalian gut bacteria into antiinflammatory isothiocyanates, such as sulforaphane. Gut microbiota exhibit biogeographic patterns, but it is unknown if colitis alters these or whether the location of glucoraphanin-metabolizing bacteria affects antiinflammatory benefits. We fed specific pathogen-free C57BL/6 mice either a control diet or a 10% steamed broccoli sprout diet and gave a three-cycle regimen of 2.5% dextran sodium …
A Fleeting Glimpse Of Functional Benefit Of The Complete Dmd Gene In A Large Animal Model Of Duchenne Muscular Dystrophy, Eric P. Hoffman
A Fleeting Glimpse Of Functional Benefit Of The Complete Dmd Gene In A Large Animal Model Of Duchenne Muscular Dystrophy, Eric P. Hoffman
Pharmacy Faculty Scholarship
No abstract provided.
Clustering Microbiome Data Using Mixtures Of Logistic Normal Multinomial Models, Yuan Fang, Sanjeena Subedi
Clustering Microbiome Data Using Mixtures Of Logistic Normal Multinomial Models, Yuan Fang, Sanjeena Subedi
Pharmacy Faculty Scholarship
Discrete data such as counts of microbiome taxa resulting from next-generation sequencing are routinely encountered in bioinformatics. Taxa count data in microbiome studies are typically high-dimensional, over-dispersed, and can only reveal relative abundance therefore being treated as compositional. Analyzing compositional data presents many challenges because they are restricted to a simplex. In a logistic normal multinomial model, the relative abundance is mapped from a simplex to a latent variable that exists on the real Euclidean space using the additive log-ratio transformation. While a logistic normal multinomial approach brings flexibility for modeling the data, it comes with a heavy computational cost …
Duchenne Muscular Dystrophy From Brain To Muscle: The Role Of Brain Dystrophin Isoforms In Motor Functions, Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Dhammika Amaratunga, Yetrib Hathout, Chandra Mohan, Harry W. M. Steinbusch, Ashwin Dalal, Eric P. Hoffman, K. Ranil D. De Silva
Duchenne Muscular Dystrophy From Brain To Muscle: The Role Of Brain Dystrophin Isoforms In Motor Functions, Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Dhammika Amaratunga, Yetrib Hathout, Chandra Mohan, Harry W. M. Steinbusch, Ashwin Dalal, Eric P. Hoffman, K. Ranil D. De Silva
Pharmacy Faculty Scholarship
Brain function and its effect on motor performance in Duchenne muscular dystrophy (DMD) is an emerging concept. The present study explored how cumulative dystrophin isoform loss, age, and a corticosteroid treatment affect DMD motor outcomes. A total of 133 genetically confirmed DMD patients from Sri Lanka were divided into two groups based on whether their shorter dystrophin isoforms (Dp140, Dp116, and Dp71) were affected: Group 1, containing patients with Dp140, Dp116, and Dp71 affected (n = 98), and Group 2, containing unaffected patients (n = 35). A subset of 52 patients (Group 1, n = 38; Group 2, n = …
An Analysis Of Patterns Of Distribution Of Buprenorphine In The United States Using Arcos, Medicaid, And Medicare Databases, Zhi-Shan Hsu, Justina A. Warnick, Tice R. Harkins, Briana E. Sylvester, Neal K. Bharati, Letausjua B. Eley, Stephanie D. Nichols, Kenneth Mccall, Brian J. Piper
An Analysis Of Patterns Of Distribution Of Buprenorphine In The United States Using Arcos, Medicaid, And Medicare Databases, Zhi-Shan Hsu, Justina A. Warnick, Tice R. Harkins, Briana E. Sylvester, Neal K. Bharati, Letausjua B. Eley, Stephanie D. Nichols, Kenneth Mccall, Brian J. Piper
Pharmacy Faculty Scholarship
Opioid overdose remains a problem in the United States despite pharmacotherapies, such as buprenorphine, in the treatment of opioid use disorder. This study characterized changes in buprenorphine use. Using the Drug Enforcement Administration's ARCOS, Medicaid, and Medicare claims databases, patterns in buprenorphine usage in the United States from 2018 to 2020 were analyzed by examining percentage changes in total grams distributed and changes in grams per 100 K people in year-to-year usage based on ZIP code and state levels. For ARCOS from 2018 to 2019 and 2019 to 2020, total buprenorphine distribution in grams increased by 16.2% and 12.6%, respectively. …
Pronounced State-Level Disparities In Prescription Of Cannabinoids To Medicaid Patients, Edward Y. Liu, Kenneth L. Mccall, Brian J. Piper
Pronounced State-Level Disparities In Prescription Of Cannabinoids To Medicaid Patients, Edward Y. Liu, Kenneth L. Mccall, Brian J. Piper
Pharmacy Faculty Scholarship
Introduction: Dronabinol is approved in the USA for chemotherapy-induced nausea as well as vomiting and HIV-induced anorexia, while cannabidiol is primarily ap- proved for childhood epileptic disorders Lennox-Gastaut and Dravet syndrome. The use pattern for these prescription cannabinoids in the USA is unknown. This study examined Medicaid claims for two FDA-approved prescription cannabinoids, dronabinol and cannabidiol, approved in 1985 and 2018, respectively, from 2016–2020 to better understand the pharmacoepidemiologic trends and distribution of these drugs in US Medicaid amidst the increasing use of non-pharmaceutical formulations of cannabis. Methods: The longitudinal study analyzed Medicaid prescription claims that were calculated by extracting …
Visualizing Drug-Induced Lipid Accumulation In Lysosomes Of Live Cancer Cells With Stimulated Raman Imaging, Yuhao Yuan, Emmanuel O. Olawode, L. Nathan Tumey, Fake Lu
Visualizing Drug-Induced Lipid Accumulation In Lysosomes Of Live Cancer Cells With Stimulated Raman Imaging, Yuhao Yuan, Emmanuel O. Olawode, L. Nathan Tumey, Fake Lu
Pharmacy Faculty Scholarship
The low pH of the lysosomal compartment often results in sequestration of chemotherapeutic agents that contain positively charged basic functional groups, leading to anti-cancer drug resistance. To visualize drug localization in lysosomes and its influence on lysosomal functions, we synthesize a group of drug-like compounds that contain both a basic functional group and a bisarylbutadiyne (BADY) group as a Raman probe. With quantitative stimulated Raman scattering (SRS) imaging, we validate that the synthesized lysosomotropic (LT) drug analogs show high lysosomal affinity, which can also serve as a photostable lysosome tracker. We find that long-term retention of the LT compounds in …
Understanding And Mitigating Thiaminase Activity In Silver Carp, Patricia C. Wolfe, Amber M. Tuske, Donald E. Tillitt, Fred Allen, Katie A. Edwards
Understanding And Mitigating Thiaminase Activity In Silver Carp, Patricia C. Wolfe, Amber M. Tuske, Donald E. Tillitt, Fred Allen, Katie A. Edwards
Pharmacy Faculty Scholarship
A deficiency of thiamine (vitamin B1), an essential cofactor for enzymes involved in metabolic processes, can be caused by the enzyme thiaminase. Thiaminase in food stocks has been linked to morbidity and mortality due to thiamine depletion in many ecologically and economically important species. Thiaminase activity has been detected in certain bacteria, plants, and fish species, including carp. The invasive silver carp (Hypophthalmichthys molitrix) presents an enormous burden to ecosystems throughout the Mississippi River watershed. Its large biomass and nutritional content offer an attractive possibility as a food source for humans, wild animals, or pets. Additionally, harvesting this fish could …