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Full-Text Articles in Medicine and Health Sciences
Liquid Tissue: Proteomic Profiling Of Formalin-Fixed Tissues, Darue A. Prieto, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman
Liquid Tissue: Proteomic Profiling Of Formalin-Fixed Tissues, Darue A. Prieto, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman
Pharmaceutical Sciences Faculty Publications
Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.
Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting, Russell J. Mumper, Michael Jay
Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting, Russell J. Mumper, Michael Jay
Pharmaceutical Sciences Faculty Patents
The present invention relates to the use of nanoscintillation systems, or nanoparticles containing fluor molecules, that can be used to detect an electron-emitting or alpha-particle-emitting radioisotope in the absence of organic-solvents commonly used in organic-based liquid scintillation cocktails. The invention also relates to compositions and use of three oil-in-water microemulsion precursors that can be engineered rapidly, reproducibly, and cost-effectively to produce useful nanoparticles less than 100 nanometers.