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- School of Pharmacy Faculty Articles (24)
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Articles 1 - 30 of 50
Full-Text Articles in Medicine and Health Sciences
Family Health Portrait, Joseph A. Woelfel
Family Health Portrait, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
A Stepwise Guide To Selecting A Medicare Prescription Drug Plan, Joseph A. Woelfel
A Stepwise Guide To Selecting A Medicare Prescription Drug Plan, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Medicare Part D Resources For The Health Professional, Joseph A. Woelfel
Medicare Part D Resources For The Health Professional, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
New Take-Home Screening Tests For Colon Cancer, Joseph A. Woelfel
New Take-Home Screening Tests For Colon Cancer, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Nutritional Support In The Acute Care Patient Post-Ventricular Assist Device Placement, Abby Re, Jane M. Gervasio, Robert D. Warhurst, Gary P. Zaloga
Nutritional Support In The Acute Care Patient Post-Ventricular Assist Device Placement, Abby Re, Jane M. Gervasio, Robert D. Warhurst, Gary P. Zaloga
Scholarship and Professional Work – COPHS
Abstract from American College of Clinical Pharmacy Annual Meeting, San Francisco, CA, October 23-26, 2005.
Cis-2,6-Disubstituted Piperidines For The Treatment Of Psychostimulant Abuse And Withdrawal, Eating Disorders, And Central Nervous System Diseases And Pathologies, Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones
Cis-2,6-Disubstituted Piperidines For The Treatment Of Psychostimulant Abuse And Withdrawal, Eating Disorders, And Central Nervous System Diseases And Pathologies, Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones
Pharmaceutical Sciences Faculty Patents
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula...
To see the remainder of this abstract, please download this patent.
Hipaa Confusion And Fear About Protected Health Information, Joseph A. Woelfel
Hipaa Confusion And Fear About Protected Health Information, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
The Chemical Species Of Aluminum Influences Its Paracellular Flux Across And Uptake Into Caco-2 Cells, A Model Of Gastrointestinal Absorption, Yuzhao Zhou, Robert A. Yokel
The Chemical Species Of Aluminum Influences Its Paracellular Flux Across And Uptake Into Caco-2 Cells, A Model Of Gastrointestinal Absorption, Yuzhao Zhou, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Aluminum (Al) can cause neurotoxicity, a low-turnover osteomalacia, and microcytic anemia. To test the null hypothesis that the chemical form (species) of Al does not influence its mechanism or rate of absorption from the gastrointestinal tract, Al flux across and uptake into Caco-2 cells was investigated. Caco-2 cells were grown on porous membranes mounted in vertical diffusion chambers or in 35-mm-diameter plastic cell culture dishes. When 8 mM 27Al was introduced as the ion, citrate, maltolate, fluoride, or hydroxide, the apical to basolateral apparent permeability (Papp) of Al correlated highly with the Papp of lucifer yellow …
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six small …
Antitrypanosomal, Antileishmanial, And Antimalarial Activities Of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, A New Class Of Trypanothione Reductase Inhibitor, And Of N-Acyl Derivatives Of 2-Amino-4-Chlorophenyl Phenyl Sulfide, Seheli Parveen, M. O. Faruk Khan, Susan E. Austin, Simon L. Croft, Vanessa Yardley, Peter Rock, Kenneth T. Douglas
Antitrypanosomal, Antileishmanial, And Antimalarial Activities Of Quaternary Arylalkylammonium 2-Amino-4-Chlorophenyl Phenyl Sulfides, A New Class Of Trypanothione Reductase Inhibitor, And Of N-Acyl Derivatives Of 2-Amino-4-Chlorophenyl Phenyl Sulfide, Seheli Parveen, M. O. Faruk Khan, Susan E. Austin, Simon L. Croft, Vanessa Yardley, Peter Rock, Kenneth T. Douglas
Pharmaceutical Science and Research
Quaternization of the nitrogen atom of 2-amino-4-chlorophenyl phenyl sulfide analogues of chlorpromazine improved inhibition ∼40-fold (3′,4′-dichlorobenzyl-[5-chloro-2-phenylsulfan- ylphenylamino)-propyl]-dimethylammonium chloride inhibited trypanothione reductase from Trypanosoma cruzi with a linear competitive Ki value of 1.7 ( 0.2 µM). Molecular modelling explained docking orientations and energies by: (i) involvement of the Z-site hydrophobic pocket (roughly bounded by F396′, P398′, and L399′), (ii) ionic interactions for the cationic nitrogen with Glu-466′ or -467′. A series of N-acyl-2-amino-4-chlorophenyl sulfides showed mixed inhibition (Ki, Ki′ ) 11.3-42.8 µM). The quaternized analogues of the 2-chlorophenyl phenylsulfides had strong antitrypanosomal and antileishmanial activity in vitro against T. bruceirhodesiense STIB900, …
Toll-Like Receptor-4 Regulation Of Hepatic Cyp3a11 Metabolism In A Mouse Model Of Lps-Induced Cns Inflammation, Kerry B. Goralski, Dalya Abdulla, Christopher J. Sinal, Andre Arsenault, Kenneth W. Renton
Toll-Like Receptor-4 Regulation Of Hepatic Cyp3a11 Metabolism In A Mouse Model Of Lps-Induced Cns Inflammation, Kerry B. Goralski, Dalya Abdulla, Christopher J. Sinal, Andre Arsenault, Kenneth W. Renton
Faculty Publications and Scholarship
Central nervous system (CNS) infection and inflammation severely reduce the capacity of cytochrome P-450 metabolism in the liver. We developed a mouse model to examine the effects of CNS inflammation on hepatic cytochrome P-450 metabolism. FVB, C57BL/6, and C3H/HeouJ mice were given Escherichia coli LPS (2.5 μg) by intracerebroventricular (ICV) injection. The CNS inflammatory response was confirmed by the elevation of TNF-α and/or IL-1β proteins in the brain. In all mouse strains, LPS produced a 60–70% loss in hepatic Cyp3a11 expression and activity compared with saline-injected controls. Adrenalectomy did not prevent the loss in Cyp3a11 expression or activity, thereby precluding …
New Medicare Part D Prescription Drug Information: Preparing For The Change, Joseph A. Woelfel
New Medicare Part D Prescription Drug Information: Preparing For The Change, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
Oral Administration Of Capsules For Inhalation, Joseph A. Woelfel
Oral Administration Of Capsules For Inhalation, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
As-Needed Inhaled Corticosteroids For Mild Persistent Asthma, Joseph A. Woelfel
As-Needed Inhaled Corticosteroids For Mild Persistent Asthma, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Previous studies showed Mn influx into brain is carrier-mediated, though the putative carrier(s) were not established. Studies conducted with cultured bovine brain microvascular endothelial cells (bBMECs), which comprise the blood–brain barrier, revealed 54Mn (II) uptake positively correlated with pH, was temperature-dependent, and was sodium- and energy-independent. Brain 54Mn uptake correlated inversely with calcium (Ca) concentration, but 45Ca uptake was unaltered by high Mn concentration. Lanthanum (La), a non-selective inhibitor of several Ca channel types, as well as …
The Effects Of Price Regulation On Pharmaceutical R&D And Innovation, Heather M. O'Neill, Lena Clarissa Crain
The Effects Of Price Regulation On Pharmaceutical R&D And Innovation, Heather M. O'Neill, Lena Clarissa Crain
Business and Economics Faculty Publications
As rising health care expenditures focus government attention on slowing the growth, the pharmaceutical industry comes under increasing pressure to curb prices of ethical drugs. Pharmaceutical price regulations have been implemented in many countries to control pharmaceutical expenditures. Yet, creating innovative drugs requires enormous R&D costs, which in turn require adequate expected economic returns. Since price controls reduce profits and expected returns, as countries invoke stricter price regulations, firms will either move their R&D process into less regulated markets or move out of innovative R&D. This paper assesses the impact of drug price regulations in Japan compared to market-priced drugs …
Liquid Tissue: Proteomic Profiling Of Formalin-Fixed Tissues, Darue A. Prieto, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman
Liquid Tissue: Proteomic Profiling Of Formalin-Fixed Tissues, Darue A. Prieto, Brian L. Hood, Marlene M. Darfler, Thomas G. Guiel, David A. Lucas, Thomas P. Conrads, Timothy D. Veenstra, David B. Krizman
Pharmaceutical Sciences Faculty Publications
Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.
Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang
Oligonucleotide Delivery Systems For Camptothecins, Thomas Burke, Ayhan S. Demir, Ashok J. Chavan, Danzhou Yang
Pharmaceutical Sciences Faculty Patents
Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.
Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Pharmaceutical Sciences Faculty Patents
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.
Generic Duragesic (Fentanyl) Patches, Joseph A. Woelfel
Generic Duragesic (Fentanyl) Patches, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Bisphosphonate-Associated Jaw Osteonecrosis, Joseph A. Woelfel
Bisphosphonate-Associated Jaw Osteonecrosis, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Bone, Muscle, And Joint Problems With Bisphosphonates, Joseph A. Woelfel
Bone, Muscle, And Joint Problems With Bisphosphonates, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
A Different Drug, A Different Country, But The Same Brand Name?, Joseph A. Woelfel
A Different Drug, A Different Country, But The Same Brand Name?, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
26Al-Containing Acidic And Basic Sodium Aluminum Phosphate Preparation And Use In Studies Of Oral Aluminum Bioavailability From Foods Utilizing 26Al As An Aluminum Tracer, Robert A. Yokel, Aaron A. Urbas, Robert A. Lodder, John P. Selegue, Rebecca L. Florence
26Al-Containing Acidic And Basic Sodium Aluminum Phosphate Preparation And Use In Studies Of Oral Aluminum Bioavailability From Foods Utilizing 26Al As An Aluminum Tracer, Robert A. Yokel, Aaron A. Urbas, Robert A. Lodder, John P. Selegue, Rebecca L. Florence
Pharmaceutical Sciences Faculty Publications
We synthesized 26Al-containing acidic and basic (alkaline) sodium aluminum phosphates (SALPs) which are FDA-approved leavening and emulsifying agents, respectively, and used them to determine the oral bioavailability of aluminum incorporated in selected foods. We selected applicable methods from published syntheses (patents) and scaled them down (∼3000- and 850-fold) to prepare ∼300–400 mg of each SALP. The 26Al was incorporated at the beginning of the syntheses to maximize 26Al and 27Al equilibration and incorporate the 26Al in the naturally-occurring Al-containing chemical species of the products. Near infrared spectroscopy (NIR) and X-ray powder diffraction (XRD) were used …
Constipation Myths, Joseph A. Woelfel
Constipation Myths, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Drug Abuse Urine Tests: False-Positive Results, Joseph A. Woelfel
Drug Abuse Urine Tests: False-Positive Results, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Common Inhaled Asthma Medications – Dose Comparison And Tips For Use, Joseph A. Woelfel
Common Inhaled Asthma Medications – Dose Comparison And Tips For Use, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.
Sudafed Pe Nasal Decongestant, Joseph A. Woelfel
Sudafed Pe Nasal Decongestant, Joseph A. Woelfel
School of Pharmacy Faculty Articles
No abstract provided.