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Full-Text Articles in Medicine and Health Sciences
Identification And Characterization Of Possible Multiple Binding Sites For ((3)H)8-Oh-Dpat In The Hippocampus, Dawna Lea Evans
Identification And Characterization Of Possible Multiple Binding Sites For ((3)H)8-Oh-Dpat In The Hippocampus, Dawna Lea Evans
Masters Theses
No abstract provided.
The Effect Of Trimethyltin On The Cholinergic System Of The Rat Hippocampus, Richard L. Cannon
The Effect Of Trimethyltin On The Cholinergic System Of The Rat Hippocampus, Richard L. Cannon
Electronic Theses and Dissertations
Trimethyltin (TMT) is a neurotoxin occurring in the environment. Exposure to (TMT) is known to destroy specific neuronal components of the hippocampus in the rat and to cause clinical symptoms in exposed humans, including mnemonic deficits, that indicate hippocampal involvement. In addition to hippocampal cell loss TMT causes significant increases in cholinergic markers such as acetylcholinesterase (AChE) stain density and choline acetyltransferase (ChAT) activity in the hippocampus of rats. However, despite these observations the effect of TMT on hippocampal cholinergic system has not been investigated in detail. The purpose of the present study was to elucidate more fully the consequences …
Fixed-Ratio Size As A Determinant Of The Development Of Tolerance To Morphine, Mark J. Nickel
Fixed-Ratio Size As A Determinant Of The Development Of Tolerance To Morphine, Mark J. Nickel
Masters Theses
The acute and chronic effects of morphine were examined in pigeons exposed to a multiple schedule with fixed ratio 5, 25, and 125 components. Acute exposure to morphine (0.56-10.0 mg/kg) resulted in rate reductions under each component when the dose was 1 mg/kg or higher. With chronic exposure to 5.6 mg/kg, tolerance to the rate-reducing effects of morphine was evident under each fixed ratio component. The development of tolerance was determined to some extent by fixed-ratio size, a result similar to earlier findings with cocaine.