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Full-Text Articles in Medicine and Health Sciences
Reactions Of Organic N-Chloramines In The Gastric Fluid Of The Rat, Kathryn E. Mazina
Reactions Of Organic N-Chloramines In The Gastric Fluid Of The Rat, Kathryn E. Mazina
Chemistry & Biochemistry Theses & Dissertations
Using chlorine as a drinking water disinfectant may have potential health effects due to its reactivity with organic amino nitrogen compounds found in the stomach. Organic N-chloramines have been shown to form in the stomachs of laboratory rats. The possible reactions of N-chloramines in the stomach fluid were examined in this study using a model radiolabeled N-chloramine. 36Cl-N-Chloropiperidine, was synthesized and purified to remove 36Cl-chloride. Stomach fluid was obtained from Sprague-Dawley rats which had been first fasted for 24 or 48 hours and then administered 3 mL of deionized water. Different concentrations of radiolabeled chloramine were reacted with …
The Effects Of Xanthine Analogs On Neonatal Rat And Adult Mouse Respiration, Susan M. Reynolds
The Effects Of Xanthine Analogs On Neonatal Rat And Adult Mouse Respiration, Susan M. Reynolds
Masters Theses
Apnea, a prolonged cessation of breathing, is commonly seen in premature infants. This condition, in its severest form, can be lethal and is a suspected cause of sudden infant death syndrome (SIDS). Sometimes referred to as apnea of prematurity, recurrent apnea is presently being treated with respiratory stimulants known as methylxanthines (MX) such as theophylline and caffeine. The benefits of MXs are accompanied by central nervous system stimulation and cardiostimulation which may be detrimental to a premature infant. Theophylline (1,3-diMX) has been shown to produce some of its effects by antagonizing endogenous adenosine. Another xanthine, enprofylline (3-propylxanthine), is presently being …