Medicine and Health Sciences Commons^™

Monitoring The Leaching Of Bisphenol-A From Feminine Hygiene Products Using Fluorescence Spectroscopy, Madison Easley

Honors Theses

Bisphenol-A (BPA) is a compound commonly used as a stabilizer in plastic products, including food storage containers and thermal paper receipts. Because BPA can bind to and activate estrogen receptors, it is linked to reduced fertility, altered development, and hormone-related cancers. A recent study at NYU Medical School confirmed the presence of BPA in pantyliners, pads, tampons, feminine washes and deodorants. This is concerning due to the high absorption capacity of the vulvar skin.

For the research performed in our lab this summer, the goal was to determine if fluorescence spectrophotometry could be used to determine the presence of BPA …

Simultaneous Determination Of Bpa And Bps Using Uv/Vis Spectrophotometry And Hplc, Jean Eudes Benecyo

Honors Theses

Bisphenol A (BPA) has been one of the most used plasticizers with more than 4.8 million tons produced in 2012. BPA is also an endocrine disruptor that has been linked to adverse health effects such as cancer, obesity, behavioral and mood changes, lowered fertility, developmental changes and more in humans and other animals. The evidence of the toxicity of BPA, even at very low levels, has caused many countries to limit its use, especially in baby bottles and other baby-related hard plastic items. In these times, BPA has been replaced with other bisphenols, such as Bisphenol S (BPS). BPS is …

Ten Weeks With Green Beans...And Then Some: Determination Of Bisphenol-A (Bpa) In Canned Goods From Arkansas Markets Using Fluorescence Spectrophotometry, Rachel Pruett

Honors Theses

Bisphenol A (BPA) is a chemical widely used in production of consumer goods. It has come under scrutiny recently after being labeled as an endocrine disruptor (ED), mostly causing adverse effects in infants and young children. It has been associated with diabetes, cardiovascular disease, and abnormal maturation. Because it is so commonly used in product development, humans are exposed to BPA through various means, such as ingestion or dermal absorption. It is a concern that the combined exposure could cause serious effects even in small doses.

In canned foods, the chemical is made into an epoxy resin to provide a …

Bringing Bpa To Light: Determination Of Bisphenol A In Thermal Receipt Paper Water Samples And Lake Water Samples Using Fluorescence Spectrophotometry, Bailey Chitwood

Honors Theses

Bisphenol A (BPA) is a chemical that is commonly used in harder plastic products, in the lining of food cans, and in thermal receipt paper. The usage of BPA in common products has become a concern for humans, especially for infants and young children, because of its effects as an endocrine disrupter. BPA has been linked to diabetes, cardiovascular disease, obesity, and certain developmental disorders. Because of the possible effects of BPA on the development of infants and young children, the use of BPA in baby bottles and other baby products has been outlawed. However, BPA is still used in …

Protective Effects Of Aqueous Extract Of Terminalia Arjuna Bark Against Doxorubicin-Induced Cardiotoxicity, Sarah Elizabeth Bishop

Honors Theses

The bark of Terminalia arjuna (TA), a tropical tree, has been used in Ayurvedic medicine for treatment of cardiovascular disease. TA bark is known to contain various antioxidants, and recently it has been suggested to enhance function of the normal heart as an over-the-counter supplement in the USA. The mechanism underlying cardiac actions of TA bark are unknown. Doxorubicin (DOX), a commonly-used anticancer drug, is known to cause cardiotoxicity, a major concern in chemotherapy. The aim of this study is to investigate whether aqueous extracts of TA bark (TAaq) protect the heart from DOX treatment by …

My Experience Exploring The Effects Of Lead (Pb +2) Toxicity In Drosophila Melanogaster Using Sociability Interaction Testing And Microarrays At The University Of Puerto Rico-Rio Piedras In San Juan, Puerto Rico, Charlton Diaz

Honors Theses

Lead is an environmental contaminant widely dispersed throughout the world. Exposure to lead causes neurological damage in humans and may be linked to neurodevelopmental pathologies such as attention deficit hyperactivity disorder, antisocial behavior, and autistic spectrum disorders (ASD). Drosophila melanogaster (fruit flies) have been used to understand the behavioral, synaptic, and molecular changes that occur after developmental exposure to lead and to study ASD-associated pathology. Flies were exposed through the mother and until eclosion to either a lead-laced medium or a control corn-based medium and were isolated until the beginning for the behavioral studies. Sociability testing was done using a …

Mitoxantrone Represses Markers Of Microglial Activation And Inflammation, Cameron A. Tull

Honors Theses

Multiple sclerosis (MS) is a neurodegenerative disease characterized by an autoimmune attack against myelin sheaths in the central nervous system (CNS). Resulting debilitations vary from sensory, motor, and coordination abnormalities to visual difficulties as well as bowel, bladder, sexual, and cognitive dysfunction (Fox, 2006). Mitoxantrone (Novantrone) is an FDAapproved drug used to treat the secondary-progressive form ofMS due to its demonstrated immunosuppressive properties. While the mechanism of action of mitoxantrone is not yet well understood, and is limited in its use due to cardiotoxicity, the aim of this study was to determine the effect of mitoxantrone on microglial and astrocyte …