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Pfapa: A Periodic Febrile Syndrome Afflicting Children, Jessica Lahti
Pfapa: A Periodic Febrile Syndrome Afflicting Children, Jessica Lahti
Physician Assistant Scholarly Project Posters
• Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).
• Auto-inflammatory disorder occurring in affected children every 3-8 weeks.
• Onset around age 2; lasting into second decade of life.
• A current pathophysiologic theory is PFAPA is a disorder of the innate immune system involving interleukins, chemoattractants, and cytokines that stimulating the inflammatory response causing symptoms associated with PFAPA.
• Early diagnosis of PFAPA may help prevent the unnecessary use of antibiotics.
• Biomarker CD64, galectin-3 and the MPV may be useful in the diagnosis of PFAPA along with other laboratory values during the febrile attack period …