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Full-Text Articles in Medicine and Health Sciences
A Unique Case Of Urinary Bladder Simple Melanosis: A Case Report And Review Of The Literature, Bo Jin, Syed Y. Zaidi, Melvin Hollowell, Christopher Hollowell, Husain Saleh
A Unique Case Of Urinary Bladder Simple Melanosis: A Case Report And Review Of The Literature, Bo Jin, Syed Y. Zaidi, Melvin Hollowell, Christopher Hollowell, Husain Saleh
Wayne State University Associated BioMed Central Scholarship
Abstract
Melanosis refers to abnormal or excessive deposition of melanin pigment in the cells and/or tissue, which can be seen in any organ but commonly in skin and oral mucosa. Melanosis of the urinary bladder is an extremely rare benign condition and only a handful of cases been reported in the English literature before. In this article, we report a new case of urinary melanosis, describe the differential diagnostic features from pseudomelanosis and offer clues for correct diagnosis. We also provide comprehensive review of the literature on the subject.
An Mdm2 Antagonist (Mi-319) Restores P53 Functions And Increases The Life Span Of Orally Treated Follicular Lymphoma Bearing Animals, Ramzi M. Mohammad, Jack Wu, Asfar S. Azmi, Amro Aboukameel, Angela Sosin, Sherwin Wu, Dajun Yang, Shaomeng Wang, Ayad M. Al-Katib
An Mdm2 Antagonist (Mi-319) Restores P53 Functions And Increases The Life Span Of Orally Treated Follicular Lymphoma Bearing Animals, Ramzi M. Mohammad, Jack Wu, Asfar S. Azmi, Amro Aboukameel, Angela Sosin, Sherwin Wu, Dajun Yang, Shaomeng Wang, Ayad M. Al-Katib
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this study was to evaluate anti-lymphoma activity of MI-319 in WSU-FSCCL, a B-cell follicular lymphoma line. For comparison purpose, MI-319, MI-219 and Nutlin-3 were assessed side by side against FSCCL and three other B-cell hematological tumor cell lines in growth inhibition and gene expression profiling experiments.
Results
MI-319 was shown to bind to MDM2 protein with an affinity slightly higher than that of MI-219 and Nutlin-3. …
Emerging Role Of Garcinol, The Antioxidant Chalcone From Garcinia Indica Choisy And Its Synthetic Analogs, Subhash Padhye, Aamir Ahmad, Nikhil Oswal, Fazlul H. Sarkar
Emerging Role Of Garcinol, The Antioxidant Chalcone From Garcinia Indica Choisy And Its Synthetic Analogs, Subhash Padhye, Aamir Ahmad, Nikhil Oswal, Fazlul H. Sarkar
Wayne State University Associated BioMed Central Scholarship
Abstract
Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to explain most of its observed biological activities. However, emerging evidence suggests that garcinol could be useful as an anti-cancer agent, and it is increasingly being realized that garcinol is a pleiotropic agent capable of modulating key regulatory cell signaling pathways. Here we have summarized the progress of our current research knowledge on garcinol and its observed …