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Full-Text Articles in Medicine and Health Sciences
The Efficacy Of Topical Antibiofilm Agents In A Sheep Model Of Rhinosinusitis, Peter-John Wormald
The Efficacy Of Topical Antibiofilm Agents In A Sheep Model Of Rhinosinusitis, Peter-John Wormald
Peter-John Wormald
Background: Biofilms have been shown to be resistant to conventional antibiotic treatment. This study uses a sheep biofilm model developed by our department to investigate several novel topical anti-biofilm treatments. Methods: Staphylococcal biofilms were grown in 54 sheep frontal sinuses over 8 days: Each sinus was randomized to (1) no intervention, (2) single mupirocin flush, (3) regular 12-hourly mupirocin flushes for 5 days, (4) Citric Acid Zwitterionic Surfactant (CAZS) via hydrodebrider, (5) gallium nitrate, (6) CAZS with gallium nitrate, (7) CAZS with mupirocin, and (8) saline regular flushes. Sheep were sacrificed and the sinus mucosa harvested 1 or 8 days …
The Effect Of Bacterial Biofilms On Post-Sinus Surgical Outcomes, Alkis J. Psaltis, Erik K. Weitzel, Kien R. Ha, Peter-John Wormald
The Effect Of Bacterial Biofilms On Post-Sinus Surgical Outcomes, Alkis J. Psaltis, Erik K. Weitzel, Kien R. Ha, Peter-John Wormald
Peter-John Wormald
Background: Although the existence of biofilms on the sinus mucosa with chronic rhinosinusitis (CRS) is now well established, the role that these structures play remains unclear. It is thought that biofilms may contribute to the recalcitrant and persistent nature that characterizes CRS, but little research exits documenting the effect that they have on postoperative mucosal outcomes. This article presents a retrospective analysis of sinus surgical patients and correlates the presence of biofilms with mucosal outcomes. This study was performed to evaluate the role that bacterial biofilms have on post-sinus surgical outcomes. Methods: A retrospective analysis of prospectively collected data was …