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Murine Herpetic Stromal Keratitis: Cellular And Molecular Mechanisms Involved In Its Pathogenesis, Kaustuv Banerjee

Doctoral Dissertations

Herpetic Stromal Keratitis (HSK) is a leading cause of infectious blindness resulting from corneal infection with herpes simplex virus (HSV-1). Extensive corticosteroid therapy is required to achieve remission and sometimes corneal transplantation is the only means of restoring vision. Murine model research has revealed that the immunological process that clears infection conversely leads to corneal tissue damage. This immune-pathological reaction involves complex interactions of cellular and molecular events.

Current knowledge about human and murine HSK pathogenesis is summarized in Part I. Parts II, III and IV progresses this knowledge using knockout and transgenic mice. Results in Part II clarify mechanisms …