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Full-Text Articles in Medicine and Health Sciences
Rsv-Encoded Ns2 Promotes Epithelial Cell Shedding And Distal Airway Obstruction, R. M. Liesman, U. J. Buchholz, C. L. Luongo, A. D. Proia, J. P. Divicenzo, P. L. Collins, R. J. Pickles
Rsv-Encoded Ns2 Promotes Epithelial Cell Shedding And Distal Airway Obstruction, R. M. Liesman, U. J. Buchholz, C. L. Luongo, A. D. Proia, J. P. Divicenzo, P. L. Collins, R. J. Pickles
Osteopathic Medicine, Jerry M. Wallace School of
Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in young children. The factors that contribute to the increased propensity of RSV-induced distal airway disease compared with other commonly encountered respiratory viruses remain unclear. Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal airway obstruction. Infection of human cartilaginous airway epithelium (HAE) and a hamster model of disease with recombinant respiratory viruses revealed that NS2 promotes shedding of infected epithelial cells, resulting in two consequences of virus infection. First, epithelial cell shedding accelerated the reduction of virus titers, presumably …
Formation Of Macular Inner Nuclear Layer Cysts In Optic Atrophy, K. Jiramongkolchai, M. T. Bhatti, A. D. Proia, S. F. Freedman, M. El-Dairi
Formation Of Macular Inner Nuclear Layer Cysts In Optic Atrophy, K. Jiramongkolchai, M. T. Bhatti, A. D. Proia, S. F. Freedman, M. El-Dairi
Osteopathic Medicine, Jerry M. Wallace School of
No abstract provided.
Interferon Γ–Inducible Protein-10 (Ip-10) And Eotaxin As Biomarkers In Age-Related Macular Degeneration, F. M. Mo, A. D. Proia, W. H. Johnson, D. Cyr, K. Lashkari
Interferon Γ–Inducible Protein-10 (Ip-10) And Eotaxin As Biomarkers In Age-Related Macular Degeneration, F. M. Mo, A. D. Proia, W. H. Johnson, D. Cyr, K. Lashkari
Osteopathic Medicine, Jerry M. Wallace School of
No abstract provided.
Effect Of Protein Kinase C Inhibitors And Activators On Corneal Re-Epithelialization In The Rat, A. Hirakata, A. G. Gupta, A. D. Proia
Effect Of Protein Kinase C Inhibitors And Activators On Corneal Re-Epithelialization In The Rat, A. Hirakata, A. G. Gupta, A. D. Proia
Osteopathic Medicine, Jerry M. Wallace School of
PURPOSE: To examine the ability of protein kinase C (PKC) inhibitors and activators to influence the rate of corneal re-epithelialization in the rat. METHOD: Rat corneas with 3 mm diameter central epithelial abrasions were organ-cultured in control medium or in medium with inhibitors or activators of PKC. RESULTS: In control corneas, the defect was completely re-epithelialized by 25 hr. In the presence of the PKC inhibitors staurosporine (100 nM), sphinganine (50 mumol/l), or H-7 (100 mumol/l) there were significantly larger epithelial defects than in controls after 5-25 hr of incubation. Re-epithelialization rates were similar to control corneas when the incubation …
The Effect Of Oxygen On Corneal Neovascularization, M. A. Culton, D. B. Chandler, A. D. Proia, D. W. Hickingbotham, G. K. Klintworth
The Effect Of Oxygen On Corneal Neovascularization, M. A. Culton, D. B. Chandler, A. D. Proia, D. W. Hickingbotham, G. K. Klintworth
Osteopathic Medicine, Jerry M. Wallace School of
Since tissue oxygen levels are believed to play a pivotal role in new vessel growth in several situations, we studied the effect of several oxygen concentrations (0, 10, 21, 50, 75, or 100%) on corneal vascularization induced in the rat by chemical cautery. We achieved this by perfusing known concentrations of oxygen through goggles fitted over both eyes of the rat after corneal cauterization. Neovascularization was measured in flat corneal preparations with India ink-filled vessels 4 days postcautery using computerized image analysis. The angiogenic response of rats whose eyes were continuously exposed to 0-75% oxygen were not significantly different from …