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Full-Text Articles in Medicine and Health Sciences
Keeping The Lights On: The Impact Of The Covid-19 Pandemic On Elective Total Joint Arthroplasty Utilization In The United States, Matthew W. Cole, Lacee K. Collins, Garrett H. Williams, Olivia C. Lee, William F. Sherman
Keeping The Lights On: The Impact Of The Covid-19 Pandemic On Elective Total Joint Arthroplasty Utilization In The United States, Matthew W. Cole, Lacee K. Collins, Garrett H. Williams, Olivia C. Lee, William F. Sherman
School of Medicine Faculty Publications
Background: It was estimated that up to 30,000 primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) procedures would be cancelled each week during the moratorium on elective surgeries in the United States. The purpose of this study was to analyze the impact of the COVID-19 pandemic on elective total joint arthroplasty utilization in the United States. Methods: A retrospective study was conducted using the PearlDiver database. Patients who underwent primary elective THAs and TKAs were identified and filtered by state and month from January through September of both 2019 and 2020. The volume of these procedures immediately following …
Spatial Transcriptomics Reveals Metabolic Changes Underly Age-Dependent Declines In Digit Regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, Mimi C. Sammarco
Spatial Transcriptomics Reveals Metabolic Changes Underly Age-Dependent Declines In Digit Regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, Mimi C. Sammarco
School of Medicine Faculty Publications
De novo limb regeneration after amputation is restricted in mammals to the distal digit tip. Central to this regenerative process is the blastema, a heterogeneous population of lineage-restricted, dedifferentiated cells that ultimately orchestrates regeneration of the amputated bone and surrounding soft tissue. To investigate skeletal regeneration, we made use of spatial transcriptomics to characterize the transcriptional profile specifically within the blastema. Using this technique, we generated a gene signature with high specificity for the blastema in both our spatial data, as well as other previously published single-cell RNA-sequencing transcriptomic studies. To elucidate potential mechanisms distinguishing regenerative from non-regenerative healing, we …