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Articles 1 - 30 of 37
Full-Text Articles in Medicine and Health Sciences
Back Pain In Adolescent Idiopathic Scoliosis: Frequency And Risk Factors, Stefan Sarkovich, Claudia Leonardi, Matthew Darlow, Davis Martin, Peter Issa, Tara Soria, Amy Bronstone, Carter Clement
Back Pain In Adolescent Idiopathic Scoliosis: Frequency And Risk Factors, Stefan Sarkovich, Claudia Leonardi, Matthew Darlow, Davis Martin, Peter Issa, Tara Soria, Amy Bronstone, Carter Clement
School of Public Health Faculty Publications
Purpose: Although back pain is commonly reported in patients with adolescent idiopathic scoliosis (AIS), factors that influence the presence and severity of back pain in AIS, including curve-specific variables, have not been well studied. This study aims to describe the prevalence and severity of back pain in AIS patients and determine the extent to which patient characteristics, including curve-specific factors, are associated with a higher risk of back pain in AIS. Methods: The study was a retrospective medical records review of adolescents (aged 10–17 years) diagnosed with AIS between 01/01/2018 and 12/31/2021 at an academic tertiary children’s hospital. Patients with …
Peripheral Nerve Stimulation Of The Shoulder: A Technical Primer, Sailesh Arulkumar, Elisa E. Neuchat, Eric Ly, Austin Ingwei Ly, Kiana Fahimipour, Mehul J. Desai
Peripheral Nerve Stimulation Of The Shoulder: A Technical Primer, Sailesh Arulkumar, Elisa E. Neuchat, Eric Ly, Austin Ingwei Ly, Kiana Fahimipour, Mehul J. Desai
School of Medicine Faculty Publications
Scapulalgia or shoulder pain accounts for 16% of all musculoskeletal complaints in the healthy adult population and becomes more common as we age. When this pain exceeds 3 months in duration, it is deemed to be chronic, and typically treated in an escalating manner. Spanning a continuum of conservative and non-conservative measures, chronic shoulder pain treatments range from rest and physical therapy to surgery. Since each patient presents with a unique spectrum of symptoms a customized treatment plan is often required. Over the lifetime of many of these patients, a variety of treatment options are required. One of these treatment …
Biocomposite Anchors Have Greater Yield Load And Energy Compared With All-Suture Anchors In An In Vitro Ovine Infraspinatus Tendon Repair Model, Robert A. Walton, Lindsey Liuzza, Catherine Takawira, Claudia Leonardi, Mandi J. Lopez
Biocomposite Anchors Have Greater Yield Load And Energy Compared With All-Suture Anchors In An In Vitro Ovine Infraspinatus Tendon Repair Model, Robert A. Walton, Lindsey Liuzza, Catherine Takawira, Claudia Leonardi, Mandi J. Lopez
School of Public Health Faculty Publications
Purpose: To compare tensile fatigue and strength measures of biocomposite and all-suture anchors in an ovine humerus-infraspinatus tendon model of rotator cuff repair. Methods: Infraspinatus tendons on adult ovine humeri were sharply transected at the insertion. One of each pair was assigned randomly for fixation with 2 biocomposite or all-suture anchors. Constructs were tested with 200 cycles of 20 to 70 N tensile load, and gap formation was measured at the incised tendon end every 50 cycles. They were subsequently tested to failure. Outcome measures including fatigue stiffness, hysteresis, creep, and gap formation and tensile stiffness, and yield and failure …
Lowest Instrumented Vertebrae In Early Onset Scoliosis: Is There A Role For A More Selective Approach?, Michael J. Heffernan, Claudia Leonardi, Lindsay M. Andras, Bailli Fontenot, Luke Drake, Joshua M. Pahys, John T. Smith, Peter F. Sturm, George H. Thompson, Michael P. Glotzbecker, Tyler A. Tetreault, Benjamin D. Roye, Ying Li
Lowest Instrumented Vertebrae In Early Onset Scoliosis: Is There A Role For A More Selective Approach?, Michael J. Heffernan, Claudia Leonardi, Lindsay M. Andras, Bailli Fontenot, Luke Drake, Joshua M. Pahys, John T. Smith, Peter F. Sturm, George H. Thompson, Michael P. Glotzbecker, Tyler A. Tetreault, Benjamin D. Roye, Ying Li
School of Public Health Faculty Publications
Purpose: This purpose of this study was to assess the impact of patient and implant characteristics on LIV selection in ambulatory children with EOS and to assess the relationship between the touched vertebrae (TV), the last substantially touched vertebrae (LSTV), the stable vertebrae (SV), the sagittal stable vertebrae (SSV), and the LIV. Methods: A multicenter pediatric spine database was queried for patients ages 2–10 years treated by growth friendly instrumentation with at least 2-year follow up. The relationship between the LIV and preoperative spinal height, curve magnitude, and implant type were assessed. The relationships between the TV, LSTV, SV, SSV, …
Preoperative Computed Tomography Scan In Distal Radius Fractures And The Effect On Preoperative Planning, Adam L. Haydel, Ryan C. Roubion, Cristina T. Graphia, Corinne E. Cloud, Claudia Leonardi, Christopher E. Marrero
Preoperative Computed Tomography Scan In Distal Radius Fractures And The Effect On Preoperative Planning, Adam L. Haydel, Ryan C. Roubion, Cristina T. Graphia, Corinne E. Cloud, Claudia Leonardi, Christopher E. Marrero
School of Medicine Faculty Publications
Purpose: It is unclear whether computed tomography (CT) scans alter the surgical plan when ordered before surgery for fixation of intra-articular distal radius fractures (DRFs). The purpose of this study was to determine whether a preoperative CT scan alters the planned approach (PA) or planned fixation strategy (PFS) for open reduction internal fixation of intra-articular DRFs. Methods: Radiology records were retrospectively reviewed by one trauma surgeon and two hand surgeons for 33 intra-articular DRFs that met the inclusion criteria and previously underwent open reduction internal fixation. Surgeons were initially provided only preoperative radiographs; they were asked for their PA and …
Wrist Motion Is Distinct Between Touch Screen And Manual Or Digital Devices, Mandi J. Lopez, Catherine Takawira, Mary P. Fox, Pengju Wang, Evan Boatwright, Thomas Lucak, Chin Chi Liu, Bryce Fugarino
Wrist Motion Is Distinct Between Touch Screen And Manual Or Digital Devices, Mandi J. Lopez, Catherine Takawira, Mary P. Fox, Pengju Wang, Evan Boatwright, Thomas Lucak, Chin Chi Liu, Bryce Fugarino
School of Medicine Faculty Publications
Background Restricted motion during touch screen device use may contribute to wrist overuse injuries. Wrist radioulnar deviation and extension while using touch screen devices and digital or manual counterparts in male and female medical professional dominant and non-dominant hands were quantified to test the hypothesis that mobile touch screen device use reduces wrist motion. Methods An active motion detection system was used to record wrist motion of 12 participants while: tablet swiping and turning book pages; raising a cell and traditional phone to the ear; texting and typing; and entering numbers on a cell phone and manual calculator. Medial and …
Bad To The Bone. Not All Bone Tumors Are Cancer: Case Of Long Bone Osteomyelitis, Tat W. Yau, Bennet D. Franz, Hanadi A. Osman, Jessica C. Rivera, Ashaur Azhar
Bad To The Bone. Not All Bone Tumors Are Cancer: Case Of Long Bone Osteomyelitis, Tat W. Yau, Bennet D. Franz, Hanadi A. Osman, Jessica C. Rivera, Ashaur Azhar
School of Medicine Faculty Publications
Long bone osteomyelitis could mimic bony tumor in clinical presentation and imaging studies. We present a case of a 47-year man who presented with leg pain, weight loss and night sweats that initially was thought to be related to osteosarcoma, later suffered a pathologic fracture from Staphylococcus aureus osteomyelitis. This case highlights the importance of source control of infection and careful clinical evaluation including radiographic and pathologic findings that can help physicians to differentiate between competing diagnoses.
Minoxidil Weakens Newly Synthesized Collagen In Fibrotic Synoviocytes From Osteoarthritis Patients, Stefan Sarkovich, Peter P. Issa, Andrew Longanecker, Davis Martin, Kaitlyn Redondo, Patrick Mcternan, Jennifer Simkin, Luis Marrero
Minoxidil Weakens Newly Synthesized Collagen In Fibrotic Synoviocytes From Osteoarthritis Patients, Stefan Sarkovich, Peter P. Issa, Andrew Longanecker, Davis Martin, Kaitlyn Redondo, Patrick Mcternan, Jennifer Simkin, Luis Marrero
School of Medicine Faculty Publications
Purpose: Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri-operative function, we evaluated the antifibrotic effect of Minoxidil (MXD) on formation of pyridinoline (Pyd) cross-links catalyzed by Plod2-encoded lysyl hydroxylase (LH)2b that strengthen newly synthesized type-I collagen (COL1) in fibroblastic synovial cells (FSCs) from KOA patients. MXD was predicted to decrease Pyd without significant alterations to Col1a1 transcription by FSCs stimulated with transforming growth factor (TGF)β1. Methods: Synovium from 10 KOA patients grouped by SFb severity was preserved for picrosirius and LH2b …
Minimalistic Approach To Enhanced Recovery After Pediatric Scoliosis Surgery, Scott A. Barnett, Bryant M. Song, Matthew Bauer, Matthew E. Nungesser, Claudia Leonardi, Michael J. Heffernan
Minimalistic Approach To Enhanced Recovery After Pediatric Scoliosis Surgery, Scott A. Barnett, Bryant M. Song, Matthew Bauer, Matthew E. Nungesser, Claudia Leonardi, Michael J. Heffernan
School of Medicine Faculty Publications
Purpose: Prior studies of enhanced recovery protocols (ERP) have been conducted at large institutions with abundant resources. These results may not apply at institutions with less resources directed to quality improvement efforts. The purpose of this study was to assess the value of a minimalistic enhanced recovery protocol in reducing length of stay (LOS) following PSF for adolescent idiopathic scoliosis. We hypothesized that accelerated transition to oral pain medications and mobilization alone could shorten hospital length of stay in the absence of a formal multimodal pain regimen. Methods: AIS patients aged 10–18 who underwent PSF at a tertiary pediatric hospital …
A Modern Multimodal Pain Protocol Eliminates The Need For Opioids For Most Patients Following Total Knee Arthroplasty: Results From A Retrospective Comparative Cohort Study, Leland Van Deventer, Amy Bronstone, Claudia Leonardi, Matthew Bennett, Peter Yager, Vinod Dasa
A Modern Multimodal Pain Protocol Eliminates The Need For Opioids For Most Patients Following Total Knee Arthroplasty: Results From A Retrospective Comparative Cohort Study, Leland Van Deventer, Amy Bronstone, Claudia Leonardi, Matthew Bennett, Peter Yager, Vinod Dasa
School of Medicine Faculty Publications
Purpose: Modern multimodal analgesia has been shown to significantly reduce opioid use following total knee arthroplasty (TKA). This study was conducted to determine if changing TKA discharge opioid prescriptions from automatic to upon request resulted in more opioid free recoveries without compromising pain control. Methods: Between December 2019 and August 2021, an orthopedic surgeon performed 144 primary unilateral TKAs; patients received the same multimodal analgesia protocol except for postoperative opioid prescribing. The first consecutively-treated cohort automatically received an opioid prescription following discharge (automatic group) and the second cohort received opioid prescriptions only upon request (upon request group). Opioid prescription data …
Hemoglobinopathy Is Associated With Total Hip Arthroplasty Indication Even Beyond Sickle Cell Anemia, Maxwell J. Rakutt, Daniel N. Bracey, Anna Cohen-Rosenblum, Peter K. Sculco, Franco M. Sabatini, Cale A. Jacobs, Stephen T. Duncan, David C. Landy
Hemoglobinopathy Is Associated With Total Hip Arthroplasty Indication Even Beyond Sickle Cell Anemia, Maxwell J. Rakutt, Daniel N. Bracey, Anna Cohen-Rosenblum, Peter K. Sculco, Franco M. Sabatini, Cale A. Jacobs, Stephen T. Duncan, David C. Landy
School of Medicine Faculty Publications
Background: The extent to which hemoglobinopathies other than sickle anemia (HbSS) are associated with hip osteonecrosis is unknown. Sickle cell trait (HbS), hemoglobin SC (HbSC), and sickle/β-thalassemia (HbSβTh) may also predispose to osteonecrosis of the femoral head (ONFH). We sought to compare the distributions of indications for a total hip arthroplasty (THA) in patients with and without specific hemoglobinopathies. Methods: PearlDiver, an administrative claims database, was used to identify 384,401 patients aged 18 years or older undergoing a THA not for fracture from 2010 to 2020, with patients grouped by diagnosis code (HbSS N = 210, HbSC N = 196, …
Persistent Lack Of Female Orthopaedic Sports Medicine Fellows, Tessa R. Lavorgna, Sanchita Gupta, Connor Maginnis, Shreya M. Saraf, Michaela A. Stamm, Stephanie E. Wong, Mary K. Mulcahey
Persistent Lack Of Female Orthopaedic Sports Medicine Fellows, Tessa R. Lavorgna, Sanchita Gupta, Connor Maginnis, Shreya M. Saraf, Michaela A. Stamm, Stephanie E. Wong, Mary K. Mulcahey
School of Medicine Faculty Publications
Purpose: To evaluate the gender composition of fellows, faculty, and leaders within orthopaedic sports medicine fellowship programs to provide a more complete description of gender diversity within this subspecialty. Methods: Official program websites of orthopaedic sports medicine fellowships listed on the Arthroscopy Association of North America fellowship directory were examined. Data collected for analysis included the gender of program directors, fellowship faculty, orthopaedic surgery department faculty, current sports medicine fellows, and fellows who graduated within the last 5 years. Results: Of the 132 orthopaedic sports medicine fellows in training in the United States in the 2021 to 2022 academic year, …
Keeping The Lights On: The Impact Of The Covid-19 Pandemic On Elective Total Joint Arthroplasty Utilization In The United States, Matthew W. Cole, Lacee K. Collins, Garrett H. Williams, Olivia C. Lee, William F. Sherman
Keeping The Lights On: The Impact Of The Covid-19 Pandemic On Elective Total Joint Arthroplasty Utilization In The United States, Matthew W. Cole, Lacee K. Collins, Garrett H. Williams, Olivia C. Lee, William F. Sherman
School of Medicine Faculty Publications
Background: It was estimated that up to 30,000 primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) procedures would be cancelled each week during the moratorium on elective surgeries in the United States. The purpose of this study was to analyze the impact of the COVID-19 pandemic on elective total joint arthroplasty utilization in the United States. Methods: A retrospective study was conducted using the PearlDiver database. Patients who underwent primary elective THAs and TKAs were identified and filtered by state and month from January through September of both 2019 and 2020. The volume of these procedures immediately following …
Measuring Muscle Tissue Trauma In Murine And In-Vivo Models, Tara Korbal, Jennifer Simkin, Jessica Rivera
Measuring Muscle Tissue Trauma In Murine And In-Vivo Models, Tara Korbal, Jennifer Simkin, Jessica Rivera
Medical Student Research Poster Symposium
Introduction: Extremity trauma involving bone and soft tissue injury is prone to complications such as poor tissue healing, wound dehiscence, wound infection, fracture related infection, and fracture nonunion. Increased understanding of how the local traumatized tissue affects healing is needed to reduce frequency of complications. The aim of this research is to establish methods of measuring muscle tissue trauma using discarded muscle tissue. These methods are first optimized in a murine model. Methods: After 4 mice were euthanized, we dissected out the anterior compartment of the lower extremity. We also took the tibia because it proved too difficult to remove …
Exploring The Paracrine Potential Of Peri-Articular Muscle In Response To Knee Osteoarthritis Severity, Davis Martin, Tara Soria, Jose A. Cruz-Ayala, Mary C. Gatterer, Vinod Dasa, Luis Marrero
Exploring The Paracrine Potential Of Peri-Articular Muscle In Response To Knee Osteoarthritis Severity, Davis Martin, Tara Soria, Jose A. Cruz-Ayala, Mary C. Gatterer, Vinod Dasa, Luis Marrero
Medical Student Research Poster Symposium
Skeletal muscles such as the Articularis genu (AG) undergo disuse-mediated myofiber type redistribution, atrophy, and fibrosis attributable to knee osteoarthritis (KOA). Although peri-articular musculature can differentially secrete over 600 myokines in response to exercise or arthropathy, its paracrine influence on the symptomatic severity of KOA is largely underexplored. Myostatin (Mst) and irisin myokines have been of particular interest in cardiac research for their effective modulation of hypertrophic damage and endomysial fibrosis in cardiomyopathy, which are also hallmark structural features of the KOA musculature that can impair joint function. Measuring intra-articular concentrations of Mst and irisin in the synovial fluid (SF) …
Disparities Associated With Total Joint Arthroplasty Transfusion And Complication Rates, Shelby Meckstroth, Andrew Chapple, Peter Krause, Deryk Jones, Lauren Leslie, Vinod Dasa
Disparities Associated With Total Joint Arthroplasty Transfusion And Complication Rates, Shelby Meckstroth, Andrew Chapple, Peter Krause, Deryk Jones, Lauren Leslie, Vinod Dasa
Medical Student Research Poster Symposium
Introduction: Complications such as infection, readmission and mortality occur with transfusion after total joint arthroplasty (TJA). Certain populations, including females, Black patients, patients with public insurance and older adults have higher risks of transfusion. Recently, there has been a decline in transfusion rates and a greater emphasis on equity in medicine. Therefore, our study sought to understand whether disparities in transfusion rates still exist and what variables influence transfusion rates over time. Methods: We used the Ochsner Healthcare Network database to identify TJA patients from 2013 to 2021. Fisher exact and Wilcoxon rank sum tests were used to compare categorical …
Tja Patient Demographic Before And After Covid-19 Elective Surgery Restrictions, Morgan Mccoy, Natalie C. Touchet, Anna Cohen-Rosenblum, Andrew Chapple
Tja Patient Demographic Before And After Covid-19 Elective Surgery Restrictions, Morgan Mccoy, Natalie C. Touchet, Anna Cohen-Rosenblum, Andrew Chapple
Medical Student Research Poster Symposium
Background: Total joint arthroplasty (TJA) includes total hip (THA) and total knee arthroplasty (TKA). In 2020, the COVID-19 pandemic caused cessation of non-emergent TJA operations between mid-March and April 2020. The purpose of this study is to analyze effects and potential disparities in access to care due to the COVID-19 restrictions. Methods: A database was used to examine demographics of patients undergoing TJA from May-December 2019 (Pre-COVID-19) and May-December 2020 (Post-COVID-19 restrictions). Categorical covariates were summarized by reporting counts and percentages and compared using Fisher exact tests. Continuous covariates were summarized by reporting means and standard deviations. Two-sample t-tests were …
Spatial Transcriptomics Reveals Metabolic Changes Underly Age-Dependent Declines In Digit Regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, Mimi C. Sammarco
Spatial Transcriptomics Reveals Metabolic Changes Underly Age-Dependent Declines In Digit Regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, Mimi C. Sammarco
School of Medicine Faculty Publications
De novo limb regeneration after amputation is restricted in mammals to the distal digit tip. Central to this regenerative process is the blastema, a heterogeneous population of lineage-restricted, dedifferentiated cells that ultimately orchestrates regeneration of the amputated bone and surrounding soft tissue. To investigate skeletal regeneration, we made use of spatial transcriptomics to characterize the transcriptional profile specifically within the blastema. Using this technique, we generated a gene signature with high specificity for the blastema in both our spatial data, as well as other previously published single-cell RNA-sequencing transcriptomic studies. To elucidate potential mechanisms distinguishing regenerative from non-regenerative healing, we …
Assessing Vertebral Body Rotation For Percutaneous Pedicle Screw Placement In Scoliosis Surgery, Patrik Suwak, Abhishek Kumar, Kirby Bonvillain, Matthew Darlow, Peter D'Amore, Claudia Leonardi, Leland C. Mccluskey
Assessing Vertebral Body Rotation For Percutaneous Pedicle Screw Placement In Scoliosis Surgery, Patrik Suwak, Abhishek Kumar, Kirby Bonvillain, Matthew Darlow, Peter D'Amore, Claudia Leonardi, Leland C. Mccluskey
School of Medicine Faculty Publications
Study Design: Retrospective Review. Objective: The aim of this study was to evaluate the incidence and magnitude of pedicle asymmetry as well as spinous process deviation in the healthy lumbar spine. Summary of Background Data: Minimally invasive spine surgery relies on fluoroscopic imaging as bony landmarks used for instrumentation are not exposed. The precision of techniques used to determine vertebral body rotation intraoperatively may be confounded by anatomic variation or pathology. Here, we investigate the physiologic variation in different anatomic structures of the lumbar spine used for percutaneous pedicle screw placement. Methods: 100 normal lumbar CT scans, without evidence of …
Outcomes For Hand Burns Treated With Autologous Skin Cell Suspension In 20% Tbsa And Smaller Injuries, George Malcolm Taylor, Scott A. Barnett, Charles T. Tuggle, Jeff E. Carter, Herb A. Phelan
Outcomes For Hand Burns Treated With Autologous Skin Cell Suspension In 20% Tbsa And Smaller Injuries, George Malcolm Taylor, Scott A. Barnett, Charles T. Tuggle, Jeff E. Carter, Herb A. Phelan
School of Medicine Faculty Publications
In order to address the confounder of TBSA on burn outcomes, we sought to analyze our experience with the use of autologous skin cell suspensions (ASCS) in a cohort of subjects with hand burns whose TBSA totaled 20% or less. We hypothesized that the use of ASCS in conjunction with 2:1 meshed autograft for the treatment of hand burn injuries would provide comparable outcomes to hand burns treated with sheet or minimally meshed autograft alone. A retrospective review was conducted for all deep partial and full-Thickness hand burns treated with split-Thickness autograft (STAG) at our urban verified burn center between …
Transcriptional Analysis Of Articularis Genu Sarcopenia In Osteoarthritis, Lauren Guillot, Mallory Crawford, Jose Cruz-Ayala, Cadence Gatterer, Vinod Dasa, Luis Marrero
Transcriptional Analysis Of Articularis Genu Sarcopenia In Osteoarthritis, Lauren Guillot, Mallory Crawford, Jose Cruz-Ayala, Cadence Gatterer, Vinod Dasa, Luis Marrero
Medical Student Research Poster Symposium
Knee osteoarthritis (kOA) causes atrophy and changes in myofiber distribution in regional musculature, including the Quadriceps femoris (QF) complex and the Articularis genu (AG), a mono-articular muscle that retracts the suprapatellar bursa during extension. The AG shares similar myofiber structure and innervation to the QF and can be easily sampled during total knee arthroplasty (TKA) for kOA, allowing its potential use in developing a diagnostics platform for management of peri-articuar muscle health. The differential expression of myosin heavy chains (MHC) in type (T) T1 slow oxidative (MHC7), T2a fast glycolytic (MHC2), T2a/x hybrids (co- expression of MHC2 and MHC1), and …
Analysis Of Maximal Intramedullary Nail Separation In Pediatric Femur Fractures, John Cooper, Michael Heffernan, Claudia Leonardi, Manaf Younis, William Arnold
Analysis Of Maximal Intramedullary Nail Separation In Pediatric Femur Fractures, John Cooper, Michael Heffernan, Claudia Leonardi, Manaf Younis, William Arnold
Medical Student Research Poster Symposium
Background: Pediatric femur fractures are the most common orthopedic surgery requiring hospitalizations along with monitoring for 12-24 months after discharge. Flexible intramedullary (IM) nailing is a common technique for the treatment of pediatric femur fractures and has yielded shorter time to weight-bearing and return to activity when compared to spica casting and external fixation. The nails pass through the medulla in either a ‘C-’ or ‘S-’ shaped configuration and, as a byproduct, produce three points of fixation: the proximal nail crossing, the maximal point of separation, and the distal nail crossing. Recent literature suggests that the point of maximal nail …
Differential Expression Of Fibrogenic Biomarkers In Naïve Human Synoviocytes Cultured In Synovial Fluid From Knee Osteoarthritis Patients, Jose Cruz Ayala, Peter Issa, Stefan Sarkovich, Jennifer Simkin, Vinod Dasa, Luis Marrero
Differential Expression Of Fibrogenic Biomarkers In Naïve Human Synoviocytes Cultured In Synovial Fluid From Knee Osteoarthritis Patients, Jose Cruz Ayala, Peter Issa, Stefan Sarkovich, Jennifer Simkin, Vinod Dasa, Luis Marrero
Medical Student Research Poster Symposium
The synovium maintains normal joint function by secreting the fundamental components of synovial fluid (SF), but is also susceptible to inflammatory and fibrotic thickening during osteoarthritis (OA), contributing to disease symptomology. We recently published evidence that synovial fibrosis (SFb) presents heterogeneously in a large sample of patients with end-stage OA in association with deficits in range of motion (ROM). During OA, diseased chondrocytes and synoviocytes undergo a dynamic crosstalk that influences severity of cartilage degradation and synoviopathy. Therefore, we aim to test the responses of validated commercial human fibroblast- like synoviocytes (HFLS) after stimulation with SF from high or low …
Factors Affecting Out Patient Physical Therapy Attendance Following Totalknee Arthroplasty, Michael Dubic, Gregory Benes, Justin David, Zachary Adams, Parker Say, Amy Bronstone, Claudia Leonardi, Vinod Dasa
Factors Affecting Out Patient Physical Therapy Attendance Following Totalknee Arthroplasty, Michael Dubic, Gregory Benes, Justin David, Zachary Adams, Parker Say, Amy Bronstone, Claudia Leonardi, Vinod Dasa
Medical Student Research Poster Symposium
Total knee arthroplasty is one of the main options for treatment for patients suffering severe knee pain and limitation. Post-op physical therapy (PT) is universally recommended and it has been associated with improved function. The goal of this study was to identify what patient factors (age, body mass index, home address, insurance type, marital status, highest level of education, and driving distance to clinic) were associated with engagement in and completion of a full course of PT defined as ≥ 2 sessions attended for engagement and ≥16 sessions attended for completion. PT session notes for 259 patients who had undergone …
Attenuating Collagen Deposition By Synoviocytes From Osteoarthritic Patientswith Synovial Fibrosis, Peter Issa, Stefan Sarkovich, Jose Cruz-Ayala, Vinod Dasa, Luis Marrero
Attenuating Collagen Deposition By Synoviocytes From Osteoarthritic Patientswith Synovial Fibrosis, Peter Issa, Stefan Sarkovich, Jose Cruz-Ayala, Vinod Dasa, Luis Marrero
Medical Student Research Poster Symposium
Fibrosis is the deposition of stiff extracellular matrix mostly composed of type-I collagen (COL1), which can impair function of diseased musculoskeletal components. COL1 is synthesized by myofibroblasts and mostly driven by the receptor-mediated transforming growth factor (TGF)β1- ALK5-Smad2/3 cascade. Stimulation of naïve fibroblasts with TGFβ1 induces proliferation, smooth muscle actin (SMA)+ myofibroblast differentiation, and COL1 synthesis. COL1 undergoes modifications to its triple helix, such as the conversion of lysine to hydroxylysine by Plod2-encoded lysyl hydroxylase (LH) 2b to facilitate cross-links that effectively strengthen COL1 fibrils. Synovial fibrosis (SFb) is a hallmark of osteoarthritis (OA) characterized by aberrant COL1 deposition in …
Rare Case Of Diffuse Skeletal Fluorosis Due To Inhalant Abuse Of Difluoroethane, Olivia G. Leonovicz, Patrik Suwak, J Chandler Van Dyke, Kaleb J. Robin, Matthew G. Cable
Rare Case Of Diffuse Skeletal Fluorosis Due To Inhalant Abuse Of Difluoroethane, Olivia G. Leonovicz, Patrik Suwak, J Chandler Van Dyke, Kaleb J. Robin, Matthew G. Cable
Medical Student Research Poster Symposium
Case: We present a rare case of diffuse skeletal fluorosis in a 56-year-old man with a history of inhalation and topical abuse of aerosolized dust cleaner containing difluoroethane as well as prior industrial exposure to chlorofluorocarbon-rich organic solvent cleaners. This patient had diffuse osteosclerotic bone disease on radiographs that elicited concern for a potentially aggressive physiologic or pathologic process, until increased fluoremia was identified as the cause. Management was conservative with removal of the causative agent. Conclusion: Skeletal fluorosis is an osteosclerotic bone disease caused by excessive ingestion of fluoride. Although this pathology is endemic in some parts of the …
The Development Of A Novel Gene Therapy, Flexion’S Fx201, For Thetreatment Of Osteoarthritis, Andrew Longanecker, Jessica Rivera, Luis Marrero, Vinod Dasa, Becca Senter, Jennifer Simkin
The Development Of A Novel Gene Therapy, Flexion’S Fx201, For Thetreatment Of Osteoarthritis, Andrew Longanecker, Jessica Rivera, Luis Marrero, Vinod Dasa, Becca Senter, Jennifer Simkin
Medical Student Research Poster Symposium
Background: Osteoarthritis is a complex multifactorial disorder that is the most frequent cause of pain, loss of function, and disability in adults1. Many modalities of treatment involve symptom alleviation but typically lead to joint replacement in end-stage disease. Consequently, there has been a shift towards the prevention of disease progression of early osteoarthritis. Due to advances in biochemical marker development, pro-inflammatory interleukins, specifically interleukin 1β (IL1β), has come into focus2. IL1β is implicated in many of the pathological advancement of osteoarthritis such as degradation of cartilage, bony malformation, and thickening of synovial tissue3-5. Previously, IL1 receptor antagonist (IL1ra) proved to …
Ankle Closure Methods: An Expert Survey Of Orthopedic Trauma Association (Ota) Members And Review Of The Literature, Jack Mckay, Christopher Bloise, Claudia Leonardi, Peter Krause
Ankle Closure Methods: An Expert Survey Of Orthopedic Trauma Association (Ota) Members And Review Of The Literature, Jack Mckay, Christopher Bloise, Claudia Leonardi, Peter Krause
Medical Student Research Poster Symposium
Ankle fractures are very common, accounting for 10.2% of all bone injuries. Due to the lack of the subcutaneous support in the area, skin closure following ankle fracture surgery is particularly challenging. The purposes of this study were to evaluate the preferences of orthopedic trauma experts regarding skin closure methods after open reduction and internal fixation (ORIF) of rotational ankle fractures and to review current literature to compare outcomes of common skin closure methods. A 23-item web-based questionnaire was advertised to active members of the Orthopedic Trauma Association (OTA). Using a cross-sectional survey study design, we evaluated the preferences of …
Atypical Osteochondroma Of The Lumbar Spine Associated With Suprasellar Pineal Germinoma: A Case Report, Patrik Suwak, Scott A. Barnett, Bryant M. Song, Michael J. Heffernan
Atypical Osteochondroma Of The Lumbar Spine Associated With Suprasellar Pineal Germinoma: A Case Report, Patrik Suwak, Scott A. Barnett, Bryant M. Song, Michael J. Heffernan
School of Medicine Faculty Publications
BACKGROUND Osteochondromas are the most common benign bone tumor, accounting for 36% of benign bone tumors. Often found within the appendicular skeleton, osteochondromas of the spine are rare, comprising 4% to 7% of primary benign spinal tumors. CASE SUMMARY We report a case of a solitary lumbar osteochondroma in an 18-year-old male with a history of a suprasellar pineal germinoma treated with combined chemotherapy and radiation. He underwent mass excision and partial laminectomy with the ultrasonic bone scalpel (Misonix, Farmingdale, NY, United States) at the L5 Level without the use of adjuvants. The patient returned to work and full activities …
Surgeon Decision-Making For Individuals With Obesity When Indicating Total Joint Arthroplasty, William F. Sherman, Akshar H. Patel, Nisha N. Kale, Christina M. Freiberger, C. Lowry Barnes, Olivia C. Lee
Surgeon Decision-Making For Individuals With Obesity When Indicating Total Joint Arthroplasty, William F. Sherman, Akshar H. Patel, Nisha N. Kale, Christina M. Freiberger, C. Lowry Barnes, Olivia C. Lee
School of Medicine Faculty Publications
Background: Obesity is a risk factor for complications after total joint arthroplasty (TJA). This study analyzed the impact of individual surgeon demographics, financial concerns, and other factors in determining patient candidacy for TJA based on body mass index (BMI). Methods: A 21-question survey was approved by the American Association of Hip and Knee Surgeons Research Committee for distribution to its membership. Objective questions asked about surgeon or hospital BMI thresholds for offering TJA. Subjective questions asked about physician comfort discussing topics including obesity, bariatric surgery, and weight loss before TJA, as well as insurance and age considerations. Results: For TJA …