Medicine and Health Sciences Commons^™

Validation Of The Flexcell®Fx-5000 Tension System To Evaluate The Expression Of Cementum Protein-1 In Human Periodontal Ligament Cells While Under Cyclical Orthodontic Tensile Force, Allison Nicholls

Electronic Thesis and Dissertation Repository

The pressure-tension theory of orthodontic tooth movement (OTM) states that there are differences in microenvironment between the tension and compressions side within the periodontal ligament, leading to differential gene expression within those zones. Cementum protein 1 (CEMP-1) is a human-specific protein localized to the root of a tooth and may play a role in OTM. The first objective was to develop a protocol to apply tensile force to human PDL cells similar to that within the tension zone during OTM. For this, the FlexCell®FX-5000 Tension system was used and fluorescent microscopy was used to confirm validity of the protocol. The …

Debt And Stress Amongst Orthodontic Residents, Timothy Renison

Electronic Thesis and Dissertation Repository

Background: The cost of education to become an orthodontist has increased significantly over recent years which has led to an increase in debt of graduating orthodontists.

Aim: This paper aims to assess whether debt amongst orthodontic residents in North America is associated with their stress levels, attitudes towards debt, financial literacy and mathematics anxiety.

Materials and Methods: Web-based software was used to fabricate a questionnaire, based on previously validated scales, in which respondents were asked questions regarding their debt levels, stress levels, attitudes towards debt, financial literacy and math anxiety.

Results: A total of 101 orthodontic residents completed the online …

The Role Of Gsk3 Alpha And Beta In Embryonic Craniofacial Development, Harman Jassar

Electronic Thesis and Dissertation Repository

Background: The GSK-3 genes (Gsk3a and Gsk3b) have been known to affect many cellular processes and signaling pathways some of which are implicated in the growth and development of the craniofacial skeleton.

Aim: The purpose of this study was to assess the effect of chondrocyte-specific deletion of Gsk3a and Gsk3b on the size of the mandible and craniofacial skeleton in embryonic mice.

Materials & Methods: Mice were bred to generate cartilage-specific Gsk3a and Gsk3b KO mice. On embryonic day 18.5 (E18.5) the offspring were gathered by caesarian section. Whole mount skeletal staining was completed on the specimens using …