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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Predictive Modeling Of Ocular Surface Disease States Using Multiple Inflammatory Biomarkers, John L. Bradley
Predictive Modeling Of Ocular Surface Disease States Using Multiple Inflammatory Biomarkers, John L. Bradley
All ETDs from UAB
ABSTRACT Purpose The aim of this study was to adapt conjunctival impression cytology (CIC) and RNA isolation and processing procedures for gene expression analysis of ocular surface inflammatory biomarkers. The RNA yield and quality should be sufficient to enable quantitative real-time PCR of no less than 12 key target genes, with the goal of differentiating among dry eye groups. This study used the optimized inflammatory biomarker gene expression assay in a patient study to identify differences between dry eye and control participants. Materials and Methods CIC was used to collect conjunctival surface cells from 53 qualifying dry eye and control …
Within Session Repeatability Of The Tear Lab Osmolarity Test And Correlation With Other Clinical Tests For Dry Eye, Pearl Shin
All ETDs from UAB
WITHIN SESSION REPEATABILITY OF THE TEAR LAB OSMOLARITY TEST AND CORRELATION WITH OTHER CLINICAL TESTS FOR DRY EYE PEARL SHIN DEPARTMENT OF VISION SCIENCES ABSTRACT Background The human tear film consists of three primary layers that work in conjunction to provide protection and nutrition to the cornea. When a layer is disrupted, the entire tear film loses its integrity and fails to function normally. Dry eye is the most common cause of tear film disruption. Among several methods to characterize dry eye is measurement of tear osmolarity. The TearLab Osmometer is commonly used clinically for this purpose. Previous studies in …
Modulation Of The Unfolded Protein Response To Delay Apoptosis In An Autosomal Dominant Retinitis Pigmentosa Animal Model, Yogesh Bhootada
Modulation Of The Unfolded Protein Response To Delay Apoptosis In An Autosomal Dominant Retinitis Pigmentosa Animal Model, Yogesh Bhootada
All ETDs from UAB
Retinitis pigmentosa (RP) is a group of retinal degenerative diseases characterized by the loss of rod photoreceptor cells that can be followed by cone degeneration eventually culminating in total photoreceptor cell loss. This disease affects approximately 1.5 million people worldwide and can be transmitted in an autosomal dominant (ADRP) manner accounting for nearly 30% of all RP cases. Dominant rhodopsin mutations have been divided into class I and class II based on the folding of rhodopsin protein, thermal stability, and chromophore regeneration. A threonine-17-methionine (T17M) mutation in rhodopsin is a class II mutation, characterized by a thermal instability/folding defect and …
Transferring Virtual Reality Training To Real World Settings In Individuals With Low Vision And Dual-Sensory Impairments, Ellen Lambert Bowman
Transferring Virtual Reality Training To Real World Settings In Individuals With Low Vision And Dual-Sensory Impairments, Ellen Lambert Bowman
All ETDs from UAB
TRANSFERRING VIRTUAL REALITY TRAINING TO REAL WORLD SETTINGS IN INDIVIDUALS WITH LOW VISION AND DUAL-SENSORY IMPAIRMENTS ELLEN LAMBERT BOWMAN VISION SCIENCE GRADUATE PROGRAM ABSTRACT The goal of this study was to determine if individuals with low vision could learn useful visual skills in Virtual Reality and could transfer these skills to the real world. To achieve this goal, one set of Orientation & Mobility (O&M) skills, using the near lane parallel traffic surge to decide the safest timing to cross a signal controlled street, was selected. Twelve participants with vision too poor to use pedestrian signals were randomly assigned to …
The Unfolded Protein Response And Calcium Dysregulation In Autosomal Dominant Retinitis Pigmentosa Animal Models., Vishal Madhukar Shinde
The Unfolded Protein Response And Calcium Dysregulation In Autosomal Dominant Retinitis Pigmentosa Animal Models., Vishal Madhukar Shinde
All ETDs from UAB
The photoreceptor cell death in autosomal dominant retinitis pigmentosa (ADRP) is associated with molecular changes that occur due to mutations in a specific gene. S334ter RHO and P23H RHO are two ADRP rat models expressing mutant rhodopsin. The unfolded protein response (UPR) is a cellular stress response involved in the pathophysiology of several retinal disorders including P23H RHO rats. Considering our previous findings, we started our investigation by examining the status of UPR in S334ter RHO rats. As UPR tightly regulates several signaling pathways, we further studied whether UPR activation in S334ter and P23H RHO retina is accompanied by the …