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Full-Text Articles in Medicine and Health Sciences
The Relationship Of Hope To Goals And Psychological Outcomes In Patients With Advanced Lung Cancer: A Test Of Hope Theory, Kelly A. Hyland
The Relationship Of Hope To Goals And Psychological Outcomes In Patients With Advanced Lung Cancer: A Test Of Hope Theory, Kelly A. Hyland
USF Tampa Graduate Theses and Dissertations
Background. Hope is an important positive psychological construct that may help to explain how individuals cope in the context of life-threatening illness. Snyder’s hope theory states that humans are goal-oriented, and that goals link hope to psychological outcomes. The purpose of the current study was to investigate the relationship of hope to emotional well-being, meaning and purpose in life, and positive and negative affect in a sample of patients with advanced stage lung cancer. The study also sought to identify how hope relates to patients’ goals and to explore whether goal characteristics and progress in achieving goals mediated the relationship …
Response And Resistance To Paradox-Breaking Braf Inhibitor In Melanomas, Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison F. Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, Andrew E. Aplin
Response And Resistance To Paradox-Breaking Braf Inhibitor In Melanomas, Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison F. Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, Andrew E. Aplin
Department of Cancer Biology Faculty Papers
FDA-approved BRAF inhibitors produce high response rates and improve overall survival in patients with BRAF V600E/K-mutant melanoma, but are linked to pathologies associated with paradoxical ERK1/2 activation in wild-type BRAF cells. To overcome this limitation, a next-generation paradox-breaking RAF inhibitor (PLX8394) has been designed. Here, we show that by using a quantitative reporter assay, PLX8394 rapidly suppressed ERK1/2 reporter activity and growth of mutant BRAF melanoma xenografts. Ex vivo treatment of xenografts and use of a patient-derived explant system (PDeX) revealed that PLX8394 suppressed ERK1/2 signaling and elicited apoptosis more effectively than the FDA-approved BRAF inhibitor, vemurafenib. Furthermore, PLX8394 was …
The Relationship Between Self-Reported Cancer Pain And Personality In Black And White Older Adults Receiving Outpatient Cancer Care, Jessica Krok
USF Tampa Graduate Theses and Dissertations
It is well-established that personality not only affects physical health and longevity, but also mental health and coping mechanisms. One area of limited research is the relationship between cancer pain and personality. This study examined how personality traits affect reported cancer pain severity in older patients (N = 150) receiving outpatient treatment at a comprehensive cancer center. Participants were interviewed regarding their pain severity, personality, affect, and self-efficacy for pain management. Symptom data were collected from the Brief Pain Inventory, while personality data were gathered from the Ten Item Personality Inventory and the Positive and Negative Affect Schedule. Self-efficacy for …