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Oncolog, Volume 47, Number 04, April 2002, Beth Notzon, Karen Stuyck, Felipe Samaniego Md
Oncolog, Volume 47, Number 04, April 2002, Beth Notzon, Karen Stuyck, Felipe Samaniego Md
OncoLog MD Anderson's Report to Physicians (All issues)
- Researchers Focus on Bioimmunotherap for Treatment of Non-Hodgkin's Lymphomas
- Protocols: Non-Hodgkin's Lymphoma Studies
- House Call: The First Cancer Prevention Vaccine
- DiaLog: The Viral Origins of Lymphomas, by Felipe Samaniego, MD, Assistant Professor, Department of Lymphoma and Myeloma
- Research Consortium Recruiting Volunteers to Study the Role of Genetics in Cancer Development and Patient Care
Siva-1 Binds To And Inhibits Bcl-Xl-Mediated Protection Against Uv Radiation-Induced Apoptosis, Li Xue, Fei Chu, Yuan Cheng, Xiangjie Sun, Alip Borthakur, Manjunath Ramarao, Pramod Pandey, Mei Wu, Stuart F. Schlossman, Kanteti V. S. Prasad
Siva-1 Binds To And Inhibits Bcl-Xl-Mediated Protection Against Uv Radiation-Induced Apoptosis, Li Xue, Fei Chu, Yuan Cheng, Xiangjie Sun, Alip Borthakur, Manjunath Ramarao, Pramod Pandey, Mei Wu, Stuart F. Schlossman, Kanteti V. S. Prasad
Clinical & Translational Sciences
We previously cloned Siva-1 by using the cytoplasmic tail of CD27, a member of the tumor necrosis factor receptor family, as the bait in the yeast two-hybrid system. The Siva gene is organized into four exons that code for the predominant full-length Siva-1 transcript, whereas its alternate splice form, Siva-2, lacks exon 2 coding sequence. Various groups have demonstrated a role for Siva-1 in several apoptotic pathways. Interestingly, the proapoptotic properties of Siva-1 are lacking in Siva-2. The fact that Siva-1 is partly localized to mitochondria despite the absence of any mitochondrial targeting signal, it harbors a 20-aa-long putative amphipathic …