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Full-Text Articles in Medicine and Health Sciences
Characterization Of Iron Response In Gynecological Cell Lines, Kyle A. Bauckman
Characterization Of Iron Response In Gynecological Cell Lines, Kyle A. Bauckman
USF Tampa Graduate Theses and Dissertations
Ovarian carcinoma afflicts over 22,000 women each year with a 5 year survival rate of only 18% for stage IV patients [23]. Current treatment options are limited due to high rates of drug resistance and recurrence. Further, the identity of "precursor lesions" which give rise to various subclasses of epithelial ovarian cancer has been evasive. This is due to discovery of the cancer at already an advanced stage. Interestingly, endometriosis a benign but invasive gynecological disease has been described as a "precursor lesion" in the development of specific subtypes of ovarian cancer. Endometriotic cyst development involves the accumulation of "old …
Molecular Mechanism Of Agc Kinases In Human Malignant, Shaokun Shu
Molecular Mechanism Of Agc Kinases In Human Malignant, Shaokun Shu
USF Tampa Graduate Theses and Dissertations
The maintenance of normal cell function and tissue homeostasis is dependent on the precise regulation of multiple signaling pathways that control cellular decisions to either proliferate, differentiate, arrest cell growth, or initiate programmed cell death (apoptosis). Cancer arises when clones of mutated cells escape this balance and proliferate inappropriately without compensatory apoptosis. Deregulated cell growth occurs as a result of perturbed signal transduction that modulates or alters cellular behavior or function to keep the critical balance between the rate of cell-cycle progression (cell division) and cell growth (cell mass) on one hand, and programmed cell death (apoptosis, autophagy) on the …