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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Prevalence, Predictors, And Correlates Of Patient Concealment Of A Lung Cancer Diagnosis, Brian David Gonzalez
Prevalence, Predictors, And Correlates Of Patient Concealment Of A Lung Cancer Diagnosis, Brian David Gonzalez
USF Tampa Graduate Theses and Dissertations
Most cases of lung cancer have a commonly-understood behavioral etiology. Thus, individuals with lung cancer are often blamed for their illness by others and may therefore seek to avoid this blame by concealing their diagnosis from others. This study sought to determine the prevalence of diagnosis concealment, examine potential predictors of concealment, and test parts of a cognitive-affective-behavioral model of the effects of concealing a concealable stigma among individuals receiving treatment for lung cancer. With regard to predictors of concealment, it was hypothesized that concealment would be positively associated with male gender, introversion, and trait social anxiety and would be …
The Translational Machinery As A Target For Radiosensitization, Thomas John Hayman
The Translational Machinery As A Target For Radiosensitization, Thomas John Hayman
USF Tampa Graduate Theses and Dissertations
Current approaches aimed at improving the efficacy of radiation as a cancer treatment modality involve the development and application of molecularly targeted radiosensitizers, a strategy that requires a thorough understanding of the fundamental processes comprising the cellular radioresponse. Recent data indicating that radiation modifies gene expression primarily through translational control rather than transcriptional events suggests that mRNA translation contributes to cell survival after irradiation. The overall goal of this project is to determine whether the regulatory/rate-limiting components of the translational machinery provide targets for tumor cell radiosensitization. The majority of translation in mammalian cells occurs in a cap-dependent manner and …
Factors Associated With Fear Of Breast Cancer Recurrence Among Survivors, Jean Marie Lucas
Factors Associated With Fear Of Breast Cancer Recurrence Among Survivors, Jean Marie Lucas
USF Tampa Graduate Theses and Dissertations
The purpose of this cross-sectional, secondary data analysis was to explore, non-modifiable (stable) trait factors and modifiable (transient) state factors associated with fear of recurrence (FOR) in breast cancer survivors. Antecedent trait factors included demographic, clinical, social/behavioral factors, postulated mediator state factors included pain, fatigue, sleep disturbances, depression, state anxiety and perceived stress, and FOR was the outcome variable. The study used baseline data from an R-21 NCI funded (grant #R21CA109168) randomized control trial that examined the effects of mindfulness based stress reduction in early stage breast cancer recovery. Instruments from this study for antecedent variables (trait factors) included a …
Race/Ethnicity, Subjective And Objective Sleep Quality, Physical And Psychological Symptoms In Breast Cancer Survivors, Pinky H. Budhrani
Race/Ethnicity, Subjective And Objective Sleep Quality, Physical And Psychological Symptoms In Breast Cancer Survivors, Pinky H. Budhrani
USF Tampa Graduate Theses and Dissertations
Breast cancer is a major health problem and comprises the largest population of cancer survivors in the United States, estimated at 2.9 million women, accounting for 22% of all cancer survivors (National Cancer Institute, 2013). The advances in breast cancer screening, diagnosis and treatment has increased the importance of survivorship needs. A major concern among breast cancer survivors (BCS) is sleep disturbances. This study used an innovative approach to examine ethnic and racial disparities in sleep disturbances present in BCS. In addition, this study also explored sleep disturbances across different races/ethnicities. This study was a secondary data analysis of baseline …
Histone Deacetylases As Targets For Melanoma Immunotherapy, David Michael Woods
Histone Deacetylases As Targets For Melanoma Immunotherapy, David Michael Woods
USF Tampa Graduate Theses and Dissertations
Cancer represents the second leading cause of death in the United States. For many malignancies, currently available treatment options offer little long-lasting survival benefits to patients. However, recent studies have shown immunotherapeutic approaches to be an attractive strategy to cancer treatment. While many current immunotherapeutic strategies convey durable responses, such responses are only seen in a minority of patients. An increased understanding of the mechanisms governing tumor immunogenicity and the biology of immune responses is crucial to improving upon the efficacy of current and future cancer immunotherapies. Histone deacetylases (HDACs), enzymes classically associated with regulation of gene expression, have been …
Interrogation Of Epor Fidelity In Myelodysplastic Syndrome Hematopoiesis And Stabilization By The Immunomodulatory Agent, Lenalidomide, Kathy Lynn Mcgraw
Interrogation Of Epor Fidelity In Myelodysplastic Syndrome Hematopoiesis And Stabilization By The Immunomodulatory Agent, Lenalidomide, Kathy Lynn Mcgraw
USF Tampa Graduate Theses and Dissertations
Myelodysplastic syndromes (MDS) include a spectrum of stem cell malignancies characterized by ineffective hematopoiesis and predisposition to acute myeloid leukemia (AML) transformation. Patients are predominantly older (greater than 60 years old), with progressive cytopenias resulting from ineffective and cytologically dysplastic hematopoiesis. MDS subtypes are classified by morphologic features and bone marrow blast percentage, as well as cytogenetic pattern, as is the case for deletion 5q MDS. Interstitial deletion of the long arm of chromosome 5, del(5q), is the most common chromosomal abnormality in patients with MDS, and the 5q- syndrome, represents a distinct subset of del(5q) MDS characterized by an …