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Full-Text Articles in Medicine and Health Sciences
Radiance1: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Rebecca Maitski, Jessica Anderson, Hannah Sibley, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Radiance1: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Rebecca Maitski, Jessica Anderson, Hannah Sibley, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Objective: In this cohort of women seeking care at a university practice in the Gulf South, we aimed to identify specific delays from patient experience of abnormal uterine bleeding (AUB) to referral to gynecologic oncology (GON) with a diagnosis of endometrial cancer (EC). Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic and treatment data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to …
Predictors Of Equitable Receipt Of Next Generation Sequencing In Endometrial Cancerpatients Receiving Cancer Care In The Deep South, Amber R. Bardarson, Madison A. Keller, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Navya Nair, Andrew Chapple, Tara Castellano
Predictors Of Equitable Receipt Of Next Generation Sequencing In Endometrial Cancerpatients Receiving Cancer Care In The Deep South, Amber R. Bardarson, Madison A. Keller, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Navya Nair, Andrew Chapple, Tara Castellano
Medical Student Research Poster Symposium
Socioeconomic status remains a predictor of endometrial cancer prognosis and is correlated with advanced disease in patients. Next Generation Sequencing (NGS) provides the ability to prescribe targeted cancer therapies and increases patient survival. Race, ethnicity, and insurance status impact the use of NGS analysis, though the degree of impact remains unclear. An IRB-Approved retrospective research study was performed using data collected of gynecologic cancer patients in a southern healthcare system through use of the electronic medical record (EMR). Baseline clinicopathologic and demographic factors were collected for all endometrial cancer patients. These factors were then tested for significant association on whether …
Radiance2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Radiance2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
We aimed to identify actionable delays in care that for women with endometrial cancer (EC) from the time of gynecologic oncology (GON) referral through adjuvant therapy. A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic, treatment, and survival data were collected. Time frames between key events were calculated. Timed events were censored if there was insufficient data to make a calculation. Categorical covariates were summarized with counts and percentages; continuous variables were summarized via means and standard deviations. Categorical covariates were compared across groups using a …
Nk Cells In Uterine Cancers, Schumann Chang, Vijay Kumar, Caitlin Bauer, John Stewart
Nk Cells In Uterine Cancers, Schumann Chang, Vijay Kumar, Caitlin Bauer, John Stewart
Medical Student Research Poster Symposium
Uterine cancer, which includes endometrial cancer (EC) and cervical cancer (CC), is one of the most prevalent gynecologic malignancies amongst women. It is the fourth most common cancer for women in the United States, with more than 90% of uterine cancers occurring in the endometrium. The uterus is a mucosal immune organ that supports embryonic and fetal development. However, its immune microenvironment is continuously altered depending on female sex hormones status, which varies with menstrual cycle and pregnancy. While pregnancy is considered a controlled stage of inflammation, this is not the case in carcinogenesis. This review paper focuses on NK …
Describing The Prevalence And Unique Demographic And Clinicopathologic Features Of Hpv-Negative Cervical Cancer, Caitlyn C. Gallaspy, Joshua R. Ricks, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia M. Jernigan
Describing The Prevalence And Unique Demographic And Clinicopathologic Features Of Hpv-Negative Cervical Cancer, Caitlyn C. Gallaspy, Joshua R. Ricks, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia M. Jernigan
Medical Student Research Poster Symposium
HPV-negative cervical cancer (HPV-CC) has been described to represent 10% of cervical cancer cases and to be associated with more advanced presentation and attenuated survival outcomes. The objective of this study was to describe the prevalence of HPV-CC in our region and to compare demographics and clinicopathologic features of HPV-CC to HPV-positive cervical cancer (HPV+CC). A retrospective chart review of patients diagnosed with cervical cancer at a safety-net hospital between January 1, 2015 and December 31, 2020 was conducted. HPV status was determined by HPV testing within 6 months of histologic diagnosis. HPV-CC was defined as a negative HPV test …
Estrogen, Obesity, And Anticoagulant Protein S Contribute To Thrombosis In Mice, Alaina Guilbeau, Manoj Kumar, Laurent Mosnier, Rinku Majumder
Estrogen, Obesity, And Anticoagulant Protein S Contribute To Thrombosis In Mice, Alaina Guilbeau, Manoj Kumar, Laurent Mosnier, Rinku Majumder
Medical Student Research Poster Symposium
Protein S (PS) is an anticoagulant molecule present in humans and mice. Protein S binds and inhibits coagulation Factor IXa to control thrombin generation1 . Protein S is imperative for normal hemostasis and the prevention of life-threatening thrombotic events, as demonstrated by numerous studies of patients with PS deficiency2,3,4. Pregnant women5 and women who use estrogen-containing birth control pills 6 have lower levels of PS. Thus, it is postulated that estrogen downregulates PS expression in human. Because estrogen is synthesized by aromatase, which is highly expressed in adipose tissue7 , we expected that PS will be downregulated in obese mice …
Does Mismatch Repair Deficiency Have Similar Prognostic Value For Black Endometrial Cancer Patients Compared To Non-Black Counterparts From The Deep South?, Madison A. Keller, Amber R. Bardarson, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Andrew G. Chapple, Navya Nair, Tara Castellano
Does Mismatch Repair Deficiency Have Similar Prognostic Value For Black Endometrial Cancer Patients Compared To Non-Black Counterparts From The Deep South?, Madison A. Keller, Amber R. Bardarson, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Andrew G. Chapple, Navya Nair, Tara Castellano
Medical Student Research Poster Symposium
Introduction: Endometrial cancer (EC) disproportionately affects Black women, but we do not yet know if mismatch repair deficiency (MMRd) has an equal prognostic value in the Black EC population as their White counterparts, due to poor representation of Black patients in scientific studies. We sought to describe the impact of MMRd in a large and racially diverse Southern EC population. Methods: A retrospective cohort study of all EC patients with reported MMR testing receiving care within a large urban healthcare system of both academic and community hospitals was performed from 2018-2022. Chart review was conducted to extract patient demographic, clinicopathologic, …
Investigating The Role Of Her3 In The Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer, Margaret Larsen, Hui Lyu, Bolin Liu
Investigating The Role Of Her3 In The Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer, Margaret Larsen, Hui Lyu, Bolin Liu
Medical Student Research Poster Symposium
The majority (80%) of lung cancer patients suffer from non-small cell lung cancer (NSCLC), which has a 5-year survival rate of about 19%. Prior research has shown the importance of studying epidermal growth factor receptor (EGFR) activating mutations to better understand NSCLC. These studies have led to the development of tyrosine kinase inhibitors (TKIs) that target the EGFR mutations to combat tumor growth and metastases. First and secondgeneration EGFR-TKIs are effective in NSCLC patients with the most common EGFR mutations (exon 19 deletion (Del19) and exon 21-point mutation (L858R)); however, resistance in the form of a T790M point mutation has …
Evaluating Social Vulnerability Impact On Care & Prognosis Of Head & Neck-Nervous System Cancers In The Us, Salim C. Lutfallah, David J. Fel-Zhang, Daniel C. Chelius, Jill N. D'Souza, Jeffery C. Rastatter, Anthony M. Sheyn
Evaluating Social Vulnerability Impact On Care & Prognosis Of Head & Neck-Nervous System Cancers In The Us, Salim C. Lutfallah, David J. Fel-Zhang, Daniel C. Chelius, Jill N. D'Souza, Jeffery C. Rastatter, Anthony M. Sheyn
Medical Student Research Poster Symposium
Introduction In the current literature, the association between social determinants of health (SDH) and head & neck-nervous system cancer (HNNsC) is limited by the narrow scope of SDH assessed and the broad classifications of HNNsC. Our study utilizes the CDC-Social Vulnerability Index (SVI) to assess both the individual and collective impact of four social determinant themes on various HNNsC in US adults. Methods This retrospective cohort study utilized the SEER database to evaluate 116,373 adult patients from 1975-2017 who presented with various types of HNNsC. Patients were assigned SVI scores based on county-of-residence at the time of diagnosis, encompassing total …
Radiance 2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Radiance 2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Objective: We aimed to identify actionable delays in care that for women with endometrial cancer (EC) from the time of gynecologic oncology referral through adjuvant therapy. Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic, treatment, and survival data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to make a calculation. Categorical covariates were summarized with counts and percentages; continuous variables were summarized via …
Radiance: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Hannah Sibley, Jessica Anderson, Rebecca Maitski, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Radiance: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Hannah Sibley, Jessica Anderson, Rebecca Maitski, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Objective: In this cohort of women seeking care at a university practice in the Gulf South, we aimed to identify specific delays from patient experience of abnormal uterine bleeding (AUB) to referral to gynecologic oncology (GON) with a diagnosis of endometrial cancer (EC). Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic and treatment data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to …
Demographic And Clinical Insight Into The Comorbidities And Mortality Of Patients With Vulvar Cancer Or Dysplasia In Louisiana, Yaseen Khan, Amber R. Bardarson, Afryea L. Dunbar, Madison A. Keller, Amelia Jernigan, Andrew Chapple, Navya Nair, Tara Castellano
Demographic And Clinical Insight Into The Comorbidities And Mortality Of Patients With Vulvar Cancer Or Dysplasia In Louisiana, Yaseen Khan, Amber R. Bardarson, Afryea L. Dunbar, Madison A. Keller, Amelia Jernigan, Andrew Chapple, Navya Nair, Tara Castellano
Medical Student Research Poster Symposium
INTRODUCTION: Studies have shown that vulvar cancer and dysplasia progression is often related to human papillomavirus (HPV) or other conditions. It has been suggested that patients with HPV-related vulvar cancer or dysplasia are likely to have died from a comorbidity rather than from vulvar disease, while patients with vulvar cancer or dysplasia unrelated to HPV often present with more aggressive forms of vulvar disease. The objective of this study was to describe the causes of death in Louisiana patients with vulvar cancer or dysplasia. METHODS: Retrospective analysis of 53 Louisiana patients diagnosed with vulvar cancer or dysplasia between 2013 and …
Racial Disparity In Covid-19 Severity In Prostate Cancer Patients, Austin Noel, Yong Yi, Xiao-Cheng Wu
Racial Disparity In Covid-19 Severity In Prostate Cancer Patients, Austin Noel, Yong Yi, Xiao-Cheng Wu
Medical Student Research Poster Symposium
BACKGROUND: Past research has shown that African American cancer patients with COVID-19 have had higher hospitalization rates when compared to their Caucasian counterparts. Our study focuses on COVID-19 hospitalization rates in patients with prostate cancer. Statistics have shown that African American men are 50% more likely to develop prostate cancer in their lifetime and twice as likely to die from prostate cancer versus Caucasian men. Thus, one speculation is that racial differences in COVID-19 severity among prostate cancer patients are attributable to African American men having a higher prevalence of prostate cancer and greater risk of severe outcome. This study …
Stage Ii Endometrial Carcinoma With False Positive Para-Aortic Lymphadenopathy: The Importance Of Pretest Probability., John Cooper, Agustin A. Garcia
Stage Ii Endometrial Carcinoma With False Positive Para-Aortic Lymphadenopathy: The Importance Of Pretest Probability., John Cooper, Agustin A. Garcia
Medical Student Research Poster Symposium
Purpose: Case report to increase awareness of pretest probability in the presence of abnormal imaging findings Methods: Review of Electronic Health Records and literature review Results: This patient is a 61-year-old female with a history of intermittent vaginal spotting since her early 50’s. On physical exam, normal vaginal atrophy was observed, and bi-manual recto-vaginal exam showed normal-sized uterus without adnexal masses or nodularity. A Pap-smear with dilation and curettage revealed endometrial carcinoma, endometrioid type with squamous differentiation. Hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic sentinel biopsy, and bilateral pelvic lymphadenectomy was performed. Pathology showed a grade 1 endometrioid carcinoma with greater …
Disparities In Treatment Of Hepatocellular Carcinoma In Hepatitis C Positive Patients, José Decastro-Vázquez, Stacey Rhodes, John Hutchings, Evrim Oral, Lisa Moreno- Walton
Disparities In Treatment Of Hepatocellular Carcinoma In Hepatitis C Positive Patients, José Decastro-Vázquez, Stacey Rhodes, John Hutchings, Evrim Oral, Lisa Moreno- Walton
Medical Student Research Poster Symposium
BACKGROUND: Primary liver cancer is the sixth most diagnosed cancer and the third leading cause of cancer death worldwide in 2020, with approximately 906,000 new cases and 830,000 deaths.1 Hepatocellular Carcinoma (HCC) comprises 85-90% of primary liver cancers. Risk factors for HCC vary by region. According to recent data, Hepatitis C Virus (HCV) accounts for approximately one-third of HCC cases in the United States (US). Studies have shown HCC and HCV disproportionally impact racial/ethnic minorities in the US. This population is encouraged to perform screening in 6-months intervals to avoid delays in diagnosis and progression of the disease.2 Moreover, socioeconomic …
Notch Dependency In Triple Negative Breast Cancer Mitochondrial Metabolism, Christine Edomwande, Deniz Ucar, Giulia Monticone, Samarpan Majumder, Lucio Miele, Fokhrul Hossain
Notch Dependency In Triple Negative Breast Cancer Mitochondrial Metabolism, Christine Edomwande, Deniz Ucar, Giulia Monticone, Samarpan Majumder, Lucio Miele, Fokhrul Hossain
Medical Student Research Poster Symposium
Introduction: Triple Negative Breast Cancer (TNBC) makes up 15 – 20% of breast cancers. It has the worst prognosis amongst the breast cancer carcinomas. TNBC lacks expression of human epidermal growth factor receptor 2 (HER2) and the endocrine receptors for estrogen and progesterone. Because it is negative for all three therapeutic targets, TNBC is difficult to treat. Chemotherapy is the standard for treatment of TNBC, however, about 80% of TNBC patients do not completely respond to chemotherapy. Resistance to therapy and the recurrence of breast cancer is thought to be caused by breast cancer stem cells. Notch signaling (canonical) is …
Joint Pain: Keeping All Differentials In Mind, Hira Hasan, Sara Javadi, Erin Hauck, Lauren Raney, Emily Klepper
Joint Pain: Keeping All Differentials In Mind, Hira Hasan, Sara Javadi, Erin Hauck, Lauren Raney, Emily Klepper
Medical Student Research Poster Symposium
Introduction: Acute lymphoblastic leukemia (ALL) results from the clonal proliferation of lymphoblasts. ALL is the most common pediatric cancer, accounting for one more than 25% of all pediatric malignancies. It primarily affects children between the ages of 1 and 5, with males being slightly more affected than females. A definitive diagnosis of ALL is made by the presence of ≥20% blasts on bone marrow biopsy. The prodromal stage of ALL may last from weeks to months and presents with nonspecific symptoms such as fever and fatigue. Infiltration of the bone marrow leads to decreased production of other cell lines, leading …
Investigating The Epigenetic Role Of Spdef In Prostate Cancer Through Identification Ofproteins Involved In Spdef Function, Margaret E. Larsen, Virginia Ronchi, Mousa Vatanmakanian, Jennifer Klein, Hari K. Koul
Investigating The Epigenetic Role Of Spdef In Prostate Cancer Through Identification Ofproteins Involved In Spdef Function, Margaret E. Larsen, Virginia Ronchi, Mousa Vatanmakanian, Jennifer Klein, Hari K. Koul
Medical Student Research Poster Symposium
Prostate cancer (PCa) is the most non-cutaneous cancer diagnosed in men, and results in approximately 30,000 deaths each year in the United States. Therapy resistant PCa, known as castration-resistant prostate cancer (CRPC), does not fully respond to common therapeutics. Most of the deaths from prostate cancer are due to metastatic CRPC indicating the importance of studying PCa to formulate more effective treatments. Previous studies have shown that the SAM pointed domain containing ETS transcription factor (SPDEF) protein plays a key role in the inhibition of prostate cancer metastasis; however, the mechanism for how SPDEF regulates metastasis is still poorly understood. …
Obese Microenvironment Contributes To Mdsc Phenotype Throughepigenetic Mechanisms, Rose Luder, Ramesh Thyur Puttalingaiah, Augusto Ochoa, Maria D. Sanchez Pino
Obese Microenvironment Contributes To Mdsc Phenotype Throughepigenetic Mechanisms, Rose Luder, Ramesh Thyur Puttalingaiah, Augusto Ochoa, Maria D. Sanchez Pino
Medical Student Research Poster Symposium
Obese patients are more susceptible to developing several different types of cancer. Myeloid derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. The expanded number and heightened function of MDSC have been found in mouse models of obesity. Our preliminary data show that patients with morbid obesity (body mass index [BMI] > 40 kg/m2) also have increased numbers of MDSC in peripheral blood, which could contribute to the cancer risk. Here, we investigate in vitro whether the cholesterol, as a factor of obese microenvironment, regulates the immunosuppressive phenotype of MDSC via epigenetic mechanisms. MDSC exert their immunosuppressive …
Oligometastatic (Ogm) Disease: An Emerging Concept In Oncology, Humza Malik, Tanner Dawson, James Ellia, Agustin Garcia
Oligometastatic (Ogm) Disease: An Emerging Concept In Oncology, Humza Malik, Tanner Dawson, James Ellia, Agustin Garcia
Medical Student Research Poster Symposium
A 46-year old presented with pain in her right axilla. Medical history was significant for stage II triple negative breast cancer (TNBC) diagnosed in 2008 treated with surgery (SRG), radiation (XRT) and chemotherapy (CTX). In 2014 she had a recurrence in the axilla treated with SRG and CTX. In 2016 she was found to have a chest wall recurrence treated with CTX and XRT. In 2018 she had a new unresectable chest wall recurrence and due to prior XRT she was considered to be at high risk for tissue necrosis with additional treatment. She was then treated with chest wall …
How The Level Of Subspecialty Of Faculty Involved In An Emergency Departmentencounter Affects The Time Until Diagnosis And Time Until Initiation Of Treatment Ingynecologic Oncology, Whitney Sternfels, Taylor Lambert, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
How The Level Of Subspecialty Of Faculty Involved In An Emergency Departmentencounter Affects The Time Until Diagnosis And Time Until Initiation Of Treatment Ingynecologic Oncology, Whitney Sternfels, Taylor Lambert, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Background: An emergency room visit is an opportunity to intervene and provide the needed care in a timely fashion. However, there is great variability in the level of subspecialty of the medical professionals involved in emergency visits. We aimed to determine if different levels of subspecialty involvement during an emergency visit had an affect on the time until first interaction with a gynecologic oncologist, time until cancer diagnosis, and time until the initiation of treatment. Methods: A retrospective chart review was conducted that included women who were referred from the emergency department (ED) to gynecologic oncology at Touro Infirmary, University …
Evaluation Of Oridonin Derivatives With Protacs Against Triple-Negative Breast Cancer, Gabrielle Vontz, Doerte Raphi Fricke, Ruixia Ma, Junhai Xu, Qiang Shen
Evaluation Of Oridonin Derivatives With Protacs Against Triple-Negative Breast Cancer, Gabrielle Vontz, Doerte Raphi Fricke, Ruixia Ma, Junhai Xu, Qiang Shen
Medical Student Research Poster Symposium
Oridonin, a natural kaurene-type diterpenoid enriched in the traditional Chinese medicinal herb Rabdosia rubescens, is a promising anticancer agent that has been shown to improve survival rates of cancer patients. Although oridonin exhibits antiproliferative capabilities including induction of apoptosis and cell cycle arrest, its low potency against aggressive cancers including triple-negative breast cancer (TNBC) and poor bioavailability limit its incorporation into standard chemotherapeutic regimens. To improve oridonin’s chemotherapeutic efficacy, several derivatives containing a thiazole ring were previously synthesized and assessed. Oridonin derivative compound CYD0618 was identified as a potent anticancer agent inhibiting cancer growth both in vitro and in vivo. …
Identification Of Copy Number Variants In Hereditary Lung Cancer Families, John Waldron, Kirsten W. Termine, Anthony M. Musolf, Mariza De Andrade, Colette Gaba, Ramaswamy Govindan, Ping Yang, Ming You, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson, Diptasri Mandal
Identification Of Copy Number Variants In Hereditary Lung Cancer Families, John Waldron, Kirsten W. Termine, Anthony M. Musolf, Mariza De Andrade, Colette Gaba, Ramaswamy Govindan, Ping Yang, Ming You, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson, Diptasri Mandal
Medical Student Research Poster Symposium
Lung cancer is the most common cause of cancer mortality and the third most common cancer by incidence in the United States. While environmental factors (e.g. tobacco smoke) play an important role in its development, lung cancer risk also exhibits a high degree of heritability. Linkage analyses and genome-wide association studies have identified multiple loci associated with increased lung cancer risk; however, much of the heritability has yet to be explained by these loci. Structural mutations, including a gain or loss of DNA (copy number variants or CNVs), contribute to phenotypic diversity through dosage and/or cis-regulatory effects. CNVs are important …
Reported Lvsi And Survival Outcomes For Stage I-Ii Endometrial Cancers In A Region With Limited Access To Formal Gynecologic Pathology Review., Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Reported Lvsi And Survival Outcomes For Stage I-Ii Endometrial Cancers In A Region With Limited Access To Formal Gynecologic Pathology Review., Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Approximately 1 in 5 women with early-stage endometrial cancer (EC) will have lymphovascular space invasion (LVI). LVI reporting requires skilled evaluation and has prognostic implications that impact adjuvant treatment. Access to gynecologic pathologists (GPath) may contribute to disparate healthcare outcomes. From the practice setting of a deep south institution with no employed GPath, we aim to describe reporting rate and survival outcomes of LVI in stage I-II EC. A multicenter, IRB-approved retrospective chart review was performed at 3 hospitals with no employed GPath. Women with stage I-II EC treated with hysterectomy from 2013-2019 were included. Women were excluded if they …