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Oral Contraceptives And Skin Cancer: Is There A Link?, Kimberly Leslie, E. Espey
Oral Contraceptives And Skin Cancer: Is There A Link?, Kimberly Leslie, E. Espey
Kimberly K. Leslie
The skin expresses estrogen, progesterone, and androgen receptors. In the presence of steroid hormones, such as those contained in oral contraceptives, the skin likely responds to hormonal signals that control the cell cycle, apoptosis, DNA replication, and other cellular functions. Some estrogen-responsive pathways have the potential to promote tumor development, including the augmentation of epidermal growth factor signaling, the expression of proto-oncogenes, and inhibition of apoptosis. The question of whether oral contraceptives increase the risk for the development of skin cancer, particularly melanoma, is still an area of concern. This paper reviews the available evidence, the bulk of which suggests …
Differences In Cervical Cytologic And Histologic Findings Between Women Using Depot-Medroxyprogesterone Acetate And Oral Contraceptives, Mary Clark, C. Stockdale, L. Railsback, S. Nichols
Differences In Cervical Cytologic And Histologic Findings Between Women Using Depot-Medroxyprogesterone Acetate And Oral Contraceptives, Mary Clark, C. Stockdale, L. Railsback, S. Nichols
M. Kathleen Clark
OBJECTIVE: This study aimed to compare cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate (DMPA) and oral contraceptives (OCs) referred for colposcopy and to determine whether there were differences in the occurrence of false-positive cytologic finding between the 2 contraceptive groups. MATERIALS AND METHODS: Retrospective cohort of 1,569 premenopausal women using either DMPA or OC who were evaluated for abnormal cervical cytologic findings. Cytologic and histologic data were collected in conjunction with routine gynecologic examinations or follow-up colposcopic evaluations. chi2 tests were used to determine differences in cervical cytologic and histologic findings and the proportion of false-positive results …