Medicine and Health Sciences Commons^™

Evaluating The Bioavailability Of Carbamazepine Using A Novel Snedds Formulation, Jinwon Byun, Derrick L. Chapman, Rebecca A. Kyper, Gina M. Mattes, Zachary A. Wallace, Elisha R. Injeti

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Central to the mechanism of how drugs work are the concepts of solubility and bioavailability. Drugs enter the body via absorption into the bloodstream, arrive at the target location, and bind to receptors to cause an effect. Drugs need to be soluble enough to pass through the cell membrane to enter and exit the bloodstream. Higher solubility generally correlates to higher bioavailability. Additionally, the smaller the particle size, the easier the drug will pass through the membrane into the blood plasma. Researchers have designed a system to categorize solubility class: Class I being high permeability and high solubility, Class II …