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Communication, Encouragement, And Cancer Screening In Families With And Without Mutations For Hereditary Nonpolyposis Colorectal Cancer: A Pilot Study, Anne Ersig, Janet Williams, D. Hadley, L. Koehly

Anne L. Ersig

PURPOSE: Known and suspected mutation carriers for hereditary nonpolyposis colorectal cancer are advised to have colonoscopies every 1 to 2 years to detect colorectal cancer. Little is known about colonoscopy completion in families suspected of having hereditary nonpolyposis colorectal cancer but without identified mutations. METHODS: This study examined the effect of communication and encouragement on colonoscopy in families with and without known mutations. Twenty-three respondents from 11 families with indeterminate genetic test results were matched with 23 respondents from 11 families with mutation-positive results. Hierarchical modeling examined the effects of relational characteristics on time since last colonoscopy in index cases …