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Full-Text Articles in Medicine and Health Sciences
An Interface Of The Taste And Reward Systems In The Brainstem And Its Role In Feeding, Louis Saites
An Interface Of The Taste And Reward Systems In The Brainstem And Its Role In Feeding, Louis Saites
Theses and Dissertations (ETD)
We eat what tastes good. We also eat because it is necessary for our health. In fact, some of the most nutritious foods (e.g., vegetables) are often less appetizing, and the tastiest (e.g., fast food, ice cream) may be the least healthy. Despite the former, we may also have a lower limit of what we accept at which point nutrition becomes irrelevant (e.g., “spinach is just too yucky”). Further, we may eat unhealthily because of overwhelming urges. We investigated the complex interactions of taste and feeding at the neurobiological level using the experiments described.
In one sense, this neurobiology begins …
Torsina And The Pathophysiology Of Dyt1 Dystonia, Yu Zhao
Torsina And The Pathophysiology Of Dyt1 Dystonia, Yu Zhao
Theses and Dissertations (ETD)
The goal of my dissertation work was to examine the systems biology of torsinA, a DYT1 dystonia-associated protein, by using rodent model systems. TorsinA is a putative ATPase associated with a variety of cellular activities (AAA+). Deletion of glutamic acid residue 302/303 in TOR1A is causally associated with many cases of early-onset primary dystonia.
In our work, transient forebrain ischemia and sciatic nerve transection were used as central and peripheral neural perturbations, respectively, to gain insight into the in vivo role(s) of torsinA. Moreover, transgenic mouse models that overexpress either human mutant torsinA (hMT) or wild-type torsinA (hWT) were used …