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Full-Text Articles in Medicine and Health Sciences
Ketogenic Diet Modulates Nad+-Dependent Enzymes And Reduces Dna Damage In Hippocampus, Marwa Elamin, David N. Ruskin, Susan A. Masino, Paola Sacchetti
Ketogenic Diet Modulates Nad+-Dependent Enzymes And Reduces Dna Damage In Hippocampus, Marwa Elamin, David N. Ruskin, Susan A. Masino, Paola Sacchetti
Faculty Scholarship
© 2018 Elamin, Ruskin, Masino and Sacchetti. The ketogenic diet’s (KD) anti-seizure effects have long been documented. Recently, its therapeutic potential in multiple neurodegenerative and neurodevelopmental disorders has emerged. Yet experimental evidence for a fundamental mechanism underlying beneficial effects across numerous diseases remains lacking. We previously showed that feeding rats a KD produced an early (within 2 days) and persistent elevation of hippocampal nicotinamide adenine dinucleotide+ (NAD+), an essential metabolic coenzyme and signaling molecule. NAD+ is a marker of cellular health and a substrate for enzymes implicated in longevity and DNA damage repair such as sirtuins and poly-ADP ribose polymerase-1 …
Editorial: Metabolic Control Of Brain Homeostasis, Detlev Boison, Jochen C. Meier, Susan A. Masino
Editorial: Metabolic Control Of Brain Homeostasis, Detlev Boison, Jochen C. Meier, Susan A. Masino
Faculty Scholarship
No abstract provided.
Metabolic Dysfunction Underlying Autism Spectrum Disorder And Potential Treatment Approaches, Ning Cheng, Jong M. Rho, Susan A. Masino
Metabolic Dysfunction Underlying Autism Spectrum Disorder And Potential Treatment Approaches, Ning Cheng, Jong M. Rho, Susan A. Masino
Faculty Scholarship
Autism spectrum disorder (ASD) is characterized by deficits in sociability and communication, and increased repetitive and/or restrictive behaviors. While the etio-pathogenesis of ASD is unknown, clinical manifestations are diverse and many possible genetic and environmental factors have been implicated. As such, it has been a great challenge to identify key neurobiological mechanisms and to develop effective treatments. Current therapies focus on co-morbid conditions (such as epileptic seizures and sleep disturbances) and there is no cure for the core symptoms. Recent studies have increasingly implicated mitochondrial dysfunction in ASD. The fact that mitochondria are an integral part of diverse cellular functions …
Ketogenic Diets And Pain [Post-Print], Susan A. Masino, David N. Ruskin
Ketogenic Diets And Pain [Post-Print], Susan A. Masino, David N. Ruskin
Faculty Scholarship
Ketogenic diets are well established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.