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Full-Text Articles in Medicine and Health Sciences
Adenosine A1 Receptor-Mediated Protection Of Mouse Hippocampal Synaptic Transmission Against Oxygen And/Or Glucose Deprivation: A Comparative Study, Masahito Kawamura, David N. Ruskin, Susan A. Masino
Adenosine A1 Receptor-Mediated Protection Of Mouse Hippocampal Synaptic Transmission Against Oxygen And/Or Glucose Deprivation: A Comparative Study, Masahito Kawamura, David N. Ruskin, Susan A. Masino
Faculty Scholarship
© 2019 the American Physiological Society. Adenosine receptors are widely ex-pressed in the brain, and adenosine is a key bioactive substance for neuroprotection. In this article, we clarify systematically the role of adenosine A1 receptors during a range of timescales and conditions when a significant amount of adenosine is released. Using acute hippocampal slices obtained from mice that were wild type or null mutant for the adenosine A1 receptor, we quantified and characterized the impact of varying durations of experimental ischemia, hypoxia, and hypoglycemia on synaptic transmission in the CA1 subregion. In normal tissue, these three stressors rapidly and markedly …
Electroencephalogram As A Diagnostic Tool In Acquired Brain Injury, Michael Zarra
Electroencephalogram As A Diagnostic Tool In Acquired Brain Injury, Michael Zarra
Senior Theses and Projects
The ability of electroencephalogram (EEG) to be used as a diagnostic device for acquired brain injuries (ABI) has been conceptualized previously. Averaged event-related potentials (ERP) derived from an EEG are suitable as markers of dysfunction however, distinctive properties in the frequency domain have not been established previously. In the present study, we examined pre- existing EEG signal data of healthy adults (HA), mild ABI (mABI), and severe ABI (sABI) human groups. Through Fourier analysis performed in MATLAB, we found that individuals in our sample population (n=80) were able to be categorized into their respective group based on common neuronal activity …