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Forebrain Origins Of Glutamatergic Innervation To The Rat Paraventricular Nucleus Of The Hypothalamus: Differential Inputs To The Anterior Versus Posterior Subregions, Yvonne M. Ulrich-Lai, Kenneth R. Jones, Dana R. Ziegler, William E. Cullinan, James P. Herman
Forebrain Origins Of Glutamatergic Innervation To The Rat Paraventricular Nucleus Of The Hypothalamus: Differential Inputs To The Anterior Versus Posterior Subregions, Yvonne M. Ulrich-Lai, Kenneth R. Jones, Dana R. Ziegler, William E. Cullinan, James P. Herman
Biomedical Sciences Faculty Research and Publications
The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to mediate many of its functions. Previous work showed that vesicular glutamate transporters (VGluTs; specific markers for glutamatergic neurons) are expressed in forebrain sites that project to the PVN; however, the extent of this presumed glutamatergic innervation to the PVN is not clear. In the present study retrograde FluoroGold (FG) labeling of PVN-projecting neurons was combined with in situ hybridization for VGluT1 and VGluT2 mRNAs to identify …