Medicine and Health Sciences Commons^™

Regeneration Of Neurons In Human Brain Tissue; A Revolutionary Concept With Therapeutic Potential, Mackenzie R. Dunn

Other Undergraduate Research

There is current research to suggest that endogenous neuronal regeneration, exogenous neuronal stem cell transplantation and glial cell reprogramming could be prospective therapeutic treatments for neurodegeneration and traumatic injury. With these conditions, there is significant brain atrophy, loss of neurons and loss of synaptic connections which can have devastating effects on executive functioning, cognition, learning and memory. This review will examine these modern approaches to adult neurogenesis, and assess the viable mechanisms and future outlook of these three therapies for neurological regenerative medicine.

Essential Tremor: A Review, Grant S. Taylor

Honors Projects

Essential tremor (ET) is one of the most prevalent movement disorders globally: approximately 1% of the population is affected (Haubenberger & Hallet, 2018). In the past, ET has been grossly oversimplified clinically and pathologically and only through recent study has the complexity of the disease process and presentation been made apparent. Despite the recent advances in research regarding ET, the general public is still largely unfamiliar with the various aspects of the disease (Cristal et al., 2018). Perhaps even more surprising is the similar lack of knowledge that ET patients have regarding their own disease (Cristal et al., 2018). Recent …

Neural Correlates Of Social Pain In Psychological Disorders: Implications For Educational Settings, Skye E. Johnson

Honors Projects

Pain has long been defined as a multidimensional construct; in past research, not only have the physical and sensory aspects of pain been investigated, but also the cognitive and emotional aspects, which include the experience of social pain. This experience is generally accepted to be very distressing and can have adverse effects on one's mental health, especially for those with neurological disorders. In my paper, I examine the effects of social pain on brain activity in individuals with autism spectrum disorder (ASD) and borderline personality disorder (BPD) as compared to those who are neurotypical. This research finds that while neurotypical …

Literature Review On Drosophila Research In Parkinson’S Disease, Maryann Jaquith

Honors Projects

Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases. It is characterized by its main symptom of a tremor that usually starts in one limb. The four cardinal symptoms of PD are tremor, rigidity, bradykinesia, and postural instability. While the four cardinal symptoms are all motor symptoms there are non-motor symptoms for PD which include cognitive changes, sleeping disorders, lightheadedness, early satiety, and mood disorders. PD is characterized by dopaminergic (DA) neuron loss and the accumulation of Lewy bodies (LB) which are predominantly composed of α-synuclein (α-Syn) protein.

α-Syn is a protein found abundantly in the brain. It …

Examining Pediatric Tourette Syndrome, Alyssa Orlando

Honors Projects

Pediatric Tourette Syndrome is a complex neurological disorder. Many people associate it with swearing, however in reality it is very rarely associated with that. This paper entails my own personal experiene with Tourette Syndrome and examines potential treatment options in the pediatric population.