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A Neurovascular Decoupling During Ictal Activity In Rats With Focal Epilepsy, Rafael Torres
A Neurovascular Decoupling During Ictal Activity In Rats With Focal Epilepsy, Rafael Torres
Undergraduate Research at FIU (URFIU) Conference
The spatiotemporal profiles of neuronal activity, hemodynamics and metabolic rate in epileptic cortices during focal ictal activity were recently evaluated using modern imaging techniques in acute situations (4-aminopyridine). However, no studies have verified these profiles in chronic models of focal epilepsy. In this study, we combined electrophysiology and optical techniques to untangle the relationships between neuronal activities and hemodynamic responses during ictal periods in the cortices of rats with chronic focal epilepsy.
13 Wistar rats with focal epilepsy were used in this study. Candidate regions for a craniotomy were obtained from EEG source imaging and BOLD effect associated with interictal …