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Articles 1 - 20 of 20
Full-Text Articles in Medicine and Health Sciences
Response To Misused And Misleading: 100% Response Rate To Galcanezumab In Patients With Episodic Migraine, N. Rosen, E. Pearlman, D. Ruff, K. Day, A. J. Nagy
Response To Misused And Misleading: 100% Response Rate To Galcanezumab In Patients With Episodic Migraine, N. Rosen, E. Pearlman, D. Ruff, K. Day, A. J. Nagy
Journal Articles
No abstract provided.
Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar
Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar
Journal Articles
No abstract provided.
Tele-Monitored Tdcs Rehabilitation: Feasibility, Challenges And Future Perspectives In Parkinson's Disease, A. Cucca, K. Sharma, S. Agarwal, A. S. Feigin, M. C. Biagioni
Tele-Monitored Tdcs Rehabilitation: Feasibility, Challenges And Future Perspectives In Parkinson's Disease, A. Cucca, K. Sharma, S. Agarwal, A. S. Feigin, M. C. Biagioni
Journal Articles
© 2019 The Author(s). Transcranial direct current stimulation (tDCS) is a modality of non-invasive brain stimulation involving the application of low amplitude direct current via surface electrodes on the scalp. tDCS has been studied in healthy populations and in multiple brain disorders and has the potential to be a treatment for several neuropsychiatric conditions by virtue of its capability of influencing cognitive, motor and behavioral processes. tDCS is a generally safe technique when performed within standardized protocols in research or clinical settings. Furthermore, tDCS portability, high acceptability and user-friendly interface makes it highly appealing for telemedicine practices. The term "telemedicine" …
Sex-Related Differences In Homebound Advanced Parkinson's Disease Patients, L. Nwabuobi, W. Barbosa, M. Sweeney, S. Oyler, T. Meisel, A. Di Rocco, J. Chodosh, J. E. Fleisher
Sex-Related Differences In Homebound Advanced Parkinson's Disease Patients, L. Nwabuobi, W. Barbosa, M. Sweeney, S. Oyler, T. Meisel, A. Di Rocco, J. Chodosh, J. E. Fleisher
Journal Articles
No abstract provided.
Altered Dynamics Of Visual Contextual Interactions In Parkinson's Disease., M. I. Vanegas, A. Blangero, J. E. Galvin, A. Di Rocco, A. Quartarone, M. F. Ghilardi, S. P. Kelly
Altered Dynamics Of Visual Contextual Interactions In Parkinson's Disease., M. I. Vanegas, A. Blangero, J. E. Galvin, A. Di Rocco, A. Quartarone, M. F. Ghilardi, S. P. Kelly
Journal Articles
Over the last decades, psychophysical and electrophysiological studies in patients and animal models of Parkinson's disease (PD), have consistently revealed a number of visual abnormalities. In particular, specific alterations of contrast sensitivity curves, electroretinogram (ERG), and visual-evoked potentials (VEP), have been attributed to dopaminergic retinal depletion. However, fundamental mechanisms of cortical visual processing, such as normalization or "gain control" computations, have not yet been examined in PD patients. Here, we measured electrophysiological indices of gain control in both space (surround suppression) and time (sensory adaptation) in PD patients based on steady-state VEP (ssVEP). Compared with controls, patients exhibited a significantly …
Correction To: Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments (Vol 12, 56, 2019), M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors
Correction To: Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments (Vol 12, 56, 2019), M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors
Journal Articles
No abstract provided.
Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments, M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors
Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments, M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors
Journal Articles
No abstract provided.
Consensus Statement From The International Consensus Meeting On The Role Of Decompressive Craniectomy In The Management Of Traumatic Brain Injury: Consensus Statement, P. J. Hutchinson, A. G. Kolias, T. Tajsic, A. Adeleye, A. T. Aklilu, T. Apriawan, A. H. Bajamal, E. J. Barthelemy, J. S. Ullman, F. Servadei, +41 Additional Authors
Consensus Statement From The International Consensus Meeting On The Role Of Decompressive Craniectomy In The Management Of Traumatic Brain Injury: Consensus Statement, P. J. Hutchinson, A. G. Kolias, T. Tajsic, A. Adeleye, A. T. Aklilu, T. Apriawan, A. H. Bajamal, E. J. Barthelemy, J. S. Ullman, F. Servadei, +41 Additional Authors
Journal Articles
No abstract provided.
Prehospital Factors Associated With Discharge Outcomes: Baseline Data From The Andhra Pradesh Traumatic Brain Injury Project, K. Ram, K. Varaprasad, M. K. Krishna, N. Kannan, V. Sundar, M. Joseph, V. D. Sinha, D. Shukla, R. K. Narayan, M. S. Vavilala, +2 Additional Authors
Prehospital Factors Associated With Discharge Outcomes: Baseline Data From The Andhra Pradesh Traumatic Brain Injury Project, K. Ram, K. Varaprasad, M. K. Krishna, N. Kannan, V. Sundar, M. Joseph, V. D. Sinha, D. Shukla, R. K. Narayan, M. S. Vavilala, +2 Additional Authors
Journal Articles
© 2019 The Authors Objective: Strategies to improve traumatic brain injury (TBI) outcomes in India are ill defined. The objective of this study was to examine baseline prehospital (PH) factors associated with outcomes from the Andhra Pradesh Traumatic Brain Injury Project. Methods: We conducted a prospective observational cohort study of adult patients with TBI admitted to the primary referral hospital. Modes of injury, prehospital care and transport, and factors associated with increased in-hospital mortality were evaluated. Poisson regression with robust error variance and adjusted attributable risk percent estimates determined factors associated with outcomes. Results: A total of 447 adults (38% …
Noninvasive Sub-Organ Ultrasound Stimulation For Targeted Neuromodulation, V. Cotero, Y. Fan, T. Tsaava, A. M. Kressel, I. Hancu, T. R. Coleman, S. Zanos, K. J. Tracey, S. S. Chavan, C. Puleo, +10 Additional Authors
Noninvasive Sub-Organ Ultrasound Stimulation For Targeted Neuromodulation, V. Cotero, Y. Fan, T. Tsaava, A. M. Kressel, I. Hancu, T. R. Coleman, S. Zanos, K. J. Tracey, S. S. Chavan, C. Puleo, +10 Additional Authors
Journal Articles
© 2019, The Author(s). Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). Next, hepatic U/S stimulation is shown to modulate pathways that regulate blood glucose and is as effective as VNS in suppressing the hyperglycemic effect …
Deep Brain Stimulation: Current Challenges And Future Directions, A. M. Lozano, N. Lipsman, H. Bergman, P. Brown, S. Chabardes, J. W. Chang, K. Matthews, C. C. Mcintyre, M. Schulder, J. K. Krauss, +3 Additional Authors
Deep Brain Stimulation: Current Challenges And Future Directions, A. M. Lozano, N. Lipsman, H. Bergman, P. Brown, S. Chabardes, J. W. Chang, K. Matthews, C. C. Mcintyre, M. Schulder, J. K. Krauss, +3 Additional Authors
Journal Articles
No abstract provided.
Inhibition Of Hmgb1/Rage-Mediated Endocytosis By Hmgb1 Antagonist Box A, Anti-Hmgb1 Antibodies, And Cholinergic Agonists Suppresses Inflammation, H. Yang, H. Liu, Q. Zeng, G. H. Imperato, M. E. Addorisio, M. He, K. F. Cheng, Y. Al-Abed, S. S. Chavan, K. J. Tracey, +3 Additional Authors
Inhibition Of Hmgb1/Rage-Mediated Endocytosis By Hmgb1 Antagonist Box A, Anti-Hmgb1 Antibodies, And Cholinergic Agonists Suppresses Inflammation, H. Yang, H. Liu, Q. Zeng, G. H. Imperato, M. E. Addorisio, M. He, K. F. Cheng, Y. Al-Abed, S. S. Chavan, K. J. Tracey, +3 Additional Authors
Journal Articles
No abstract provided.
Towards Reconstructing Intelligible Speech From The Human Auditory Cortex, H. Akbari, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani
Towards Reconstructing Intelligible Speech From The Human Auditory Cortex, H. Akbari, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani
Journal Articles
No abstract provided.
An Effective Method For Acute Vagus Nerve Stimulation In Experimental Inflammation, A. S. Caravaca, A. L. Gallina, L. Tarnawski, K. J. Tracey, V. A. Pavlov, Y. A. Levine, P. S. Olofsson
An Effective Method For Acute Vagus Nerve Stimulation In Experimental Inflammation, A. S. Caravaca, A. L. Gallina, L. Tarnawski, K. J. Tracey, V. A. Pavlov, Y. A. Levine, P. S. Olofsson
Journal Articles
© 2019 Caravaca, Gallina, Tarnawski, Tracey, Pavlov, Levine and Olofsson. Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation (VNS) in treatment of rheumatoid arthritis and Crohn’s disease suggest that there is a therapeutic potential of electrical VNS in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical VNS in a range …
Spectrotemporal Modulation Provides A Unifying Framework For Auditory Cortical Asymmetries, A. Flinker, W. K. Doyle, A. D. Mehta, O. Devinsky, D. Poeppel
Spectrotemporal Modulation Provides A Unifying Framework For Auditory Cortical Asymmetries, A. Flinker, W. K. Doyle, A. D. Mehta, O. Devinsky, D. Poeppel
Journal Articles
No abstract provided.
Novel Bioactive And Therapeutic Dental Polymeric Materials To Inhibit Periodontal Pathogens And Biofilms, M. Chi, M. Qi, A. Lan, P. Wang, M. D. Weir, M. A. Melo, X. Sun, B. Dong, C. Li, H. H. Xu, +2 Additional Authors
Novel Bioactive And Therapeutic Dental Polymeric Materials To Inhibit Periodontal Pathogens And Biofilms, M. Chi, M. Qi, A. Lan, P. Wang, M. D. Weir, M. A. Melo, X. Sun, B. Dong, C. Li, H. H. Xu, +2 Additional Authors
Journal Articles
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the …
Adaptation Of The Human Auditory Cortex To Changing Background Noise, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani
Adaptation Of The Human Auditory Cortex To Changing Background Noise, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani
Journal Articles
No abstract provided.
Incins-Igf2 Promotes Cell Proliferation And Migration By Promoting G1/S Transition In Lung Cancer, S. Gao, Z. Lin, C. Li, Y. Wang, L. Yang, B. Zou, J. Chen, J. Li, D. Feng, G. Liu, +1 Additional Author
Incins-Igf2 Promotes Cell Proliferation And Migration By Promoting G1/S Transition In Lung Cancer, S. Gao, Z. Lin, C. Li, Y. Wang, L. Yang, B. Zou, J. Chen, J. Li, D. Feng, G. Liu, +1 Additional Author
Journal Articles
© The Author(s) 2019. Long noncoding RNAs are capable of regulating gene expression at multiple levels. These RNA molecules are also involved in a variety of physiological and pathological processes. Emerging data demonstrate that a series of differentially expressed long noncoding RNAs are implicated in tumorigenesis. In the present study, we used microarray analysis to identify long noncoding RNAs that are dysregulated in non-small-cell lung cancer when compared to normal lung tissues. Accordingly, we performed quantitative real-time polymerase chain reaction to analyze the levels of long noncoding RNA and the cis target gene. We further found the oncogene property of …
Efficacy And Safety Of Ozanimod In Multiple Sclerosis: Dose-Blinded Extension Of A Randomized Phase Ii Study, J. A. Cohen, G. Comi, D. L. Arnold, A. Bar-Or, K. W. Selmaj, L. Steinman, E. K. Havrdová, B. A. Cree, B. E. Skolnick, L. Kappos, +4 Additional Authors
Efficacy And Safety Of Ozanimod In Multiple Sclerosis: Dose-Blinded Extension Of A Randomized Phase Ii Study, J. A. Cohen, G. Comi, D. L. Arnold, A. Bar-Or, K. W. Selmaj, L. Steinman, E. K. Havrdová, B. A. Cree, B. E. Skolnick, L. Kappos, +4 Additional Authors
Journal Articles
© The Author(s), 2018. Background: Ozanimod, an oral immunomodulator, selectively targets sphingosine 1-phosphate receptors 1 and 5. Objective: Evaluate efficacy, safety, and tolerability of ozanimod in relapsing multiple sclerosis. Methods: In the RADIANCE Part A phase II study (NCT01628393), participants with relapsing multiple sclerosis were randomized (1:1:1) to once-daily ozanimod hydrochloride (0.5 or 1 mg) or placebo. After 24 weeks, participants could enter a 2-year, dose-blinded extension. Ozanimod-treated participants continued their assigned dose; placebo participants were re-randomized (1:1) to ozanimod hydrochloride 0.5 or 1 mg (equivalent to ozanimod 0.46 and 0.92 mg). Results: A total of 223 (89.6%) of the …
Ieeg-Bids, Extending The Brain Imaging Data Structure Specification To Human Intracranial Electrophysiology, C. Holdgraf, S. Appelhoff, S. Bickel, K. Bouchard, S. D'Ambrosio, O. David, O. Devinsky, B. Dichter, A. Flinker, D. Hermes, +29 Additional Authors
Ieeg-Bids, Extending The Brain Imaging Data Structure Specification To Human Intracranial Electrophysiology, C. Holdgraf, S. Appelhoff, S. Bickel, K. Bouchard, S. D'Ambrosio, O. David, O. Devinsky, B. Dichter, A. Flinker, D. Hermes, +29 Additional Authors
Journal Articles
No abstract provided.